Arhgef7 as a key target for enriched environment rescuing spatial cognitive deficits and anxiety-like behaviors in a mouse model of Alzheimer’s disease following early social isolation

Arhgef7 as a key target for enriched environment rescuing spatial cognitive deficits and anxiety-like behaviors in a mouse model of Alzheimer’s disease following early social isolation

Abstract Background Both social and physical environmental factors influence the progression of Alzheimer’s disease (AD), but the underlying mechanisms are not yet fully understood. This study aims to investigate how an enriched environment (EE) alleviates the detrimental effects of early social iso...

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Bibliographic Details
Main Authors: Yimiao Wang, Ze Wang, Yue Li, Min Cao, Shuying Zhang, Shixin Ding, Sijia Chen, Yuxi Jin, Yanli Zhang, Junying Gao, Ming Xiao
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Alzheimer’s Research & Therapy
Subjects:
Social isolation
Enriched physical environment
Cognitive dysfunction
Medial prefrontal cortex
Synaptic function
Online Access:https://doi.org/10.1186/s13195-025-01797-5
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