The Unfulfilled Potential of Synthetic and Biological Hydrogel Membranes in the Treatment of Abdominal Hernias
Hydrogel membranes can offer a cutting-edge solution for abdominal hernia treatment. By combining favorable mechanical parameters, tissue integration, and the potential for targeted drug delivery, hydrogels are a promising alternative therapeutic option. The current review examines the application o...
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| Format: | Article |
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MDPI AG
2024-11-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/10/12/754 |
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| author | Kenigen Manikion Christodoulos Chrysanthou Constantinos Voniatis |
| author_facet | Kenigen Manikion Christodoulos Chrysanthou Constantinos Voniatis |
| author_sort | Kenigen Manikion |
| collection | DOAJ |
| description | Hydrogel membranes can offer a cutting-edge solution for abdominal hernia treatment. By combining favorable mechanical parameters, tissue integration, and the potential for targeted drug delivery, hydrogels are a promising alternative therapeutic option. The current review examines the application of hydrogel materials composed of synthetic and biological polymers, such as polyethylene glycol (PEG), polyvinyl alcohol (PVA), gelatine, and silk fibroin, in the context of hernia repair. Overall, this review highlights the current issues and prospects of hydrogel membranes as viable alternatives to the conventional hernia meshes. The emphasis is placed on the applicability of these hydrogels as components of bilayer systems and standalone materials. According to our research, hydrogel membranes exhibit several advantageous features relevant to hernia repair, such as a controlled inflammatory reaction, tissue integration, anti-adhesive-, and even thermoresponsive properties. Nevertheless, despite significant advancements in material science, the potential of hydrogel membranes seems neglected. Bilayer constructs have not transitioned to clinical trials, whereas standalone membranes seem unreliable due to the lack of comprehensive mechanical characterization and long-term in vivo experiments. |
| format | Article |
| id | doaj-art-76eb2eeb9d4c4389a3498022d82e7642 |
| institution | DOAJ |
| issn | 2310-2861 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj-art-76eb2eeb9d4c4389a3498022d82e76422025-08-20T02:55:33ZengMDPI AGGels2310-28612024-11-01101275410.3390/gels10120754The Unfulfilled Potential of Synthetic and Biological Hydrogel Membranes in the Treatment of Abdominal HerniasKenigen Manikion0Christodoulos Chrysanthou1Constantinos Voniatis2Laboratory of Nanochemistry, Department of Biophysics and Radiation Biology, Semmelweis University, Tűzoltó Street 37-47, H-1094 Budapest, HungaryLaboratory of Nanochemistry, Department of Biophysics and Radiation Biology, Semmelweis University, Tűzoltó Street 37-47, H-1094 Budapest, HungaryLaboratory of Nanochemistry, Department of Biophysics and Radiation Biology, Semmelweis University, Tűzoltó Street 37-47, H-1094 Budapest, HungaryHydrogel membranes can offer a cutting-edge solution for abdominal hernia treatment. By combining favorable mechanical parameters, tissue integration, and the potential for targeted drug delivery, hydrogels are a promising alternative therapeutic option. The current review examines the application of hydrogel materials composed of synthetic and biological polymers, such as polyethylene glycol (PEG), polyvinyl alcohol (PVA), gelatine, and silk fibroin, in the context of hernia repair. Overall, this review highlights the current issues and prospects of hydrogel membranes as viable alternatives to the conventional hernia meshes. The emphasis is placed on the applicability of these hydrogels as components of bilayer systems and standalone materials. According to our research, hydrogel membranes exhibit several advantageous features relevant to hernia repair, such as a controlled inflammatory reaction, tissue integration, anti-adhesive-, and even thermoresponsive properties. Nevertheless, despite significant advancements in material science, the potential of hydrogel membranes seems neglected. Bilayer constructs have not transitioned to clinical trials, whereas standalone membranes seem unreliable due to the lack of comprehensive mechanical characterization and long-term in vivo experiments.https://www.mdpi.com/2310-2861/10/12/754surgical meshesbilayer membranesmechanical studiesin vivo studiestissue engineering |
| spellingShingle | Kenigen Manikion Christodoulos Chrysanthou Constantinos Voniatis The Unfulfilled Potential of Synthetic and Biological Hydrogel Membranes in the Treatment of Abdominal Hernias Gels surgical meshes bilayer membranes mechanical studies in vivo studies tissue engineering |
| title | The Unfulfilled Potential of Synthetic and Biological Hydrogel Membranes in the Treatment of Abdominal Hernias |
| title_full | The Unfulfilled Potential of Synthetic and Biological Hydrogel Membranes in the Treatment of Abdominal Hernias |
| title_fullStr | The Unfulfilled Potential of Synthetic and Biological Hydrogel Membranes in the Treatment of Abdominal Hernias |
| title_full_unstemmed | The Unfulfilled Potential of Synthetic and Biological Hydrogel Membranes in the Treatment of Abdominal Hernias |
| title_short | The Unfulfilled Potential of Synthetic and Biological Hydrogel Membranes in the Treatment of Abdominal Hernias |
| title_sort | unfulfilled potential of synthetic and biological hydrogel membranes in the treatment of abdominal hernias |
| topic | surgical meshes bilayer membranes mechanical studies in vivo studies tissue engineering |
| url | https://www.mdpi.com/2310-2861/10/12/754 |
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