Biochemical mechanisms and molecular interactions of vitamins in cancer therapy
Recently, the potential role of vitamins in cancer therapy has attracted considerable research attention. However, the reported findings are inconsistent, with limited information on the biochemical and molecular interactions of different vitamins in various cancer cells. Importantly, the presence o...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Cancer Pathogenesis and Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949713224000302 |
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| author | Abdullahi T. Aborode Isreal A. Onifade Mercy M. Olorunshola Gladys O. Adenikinju Ibude J. Aruorivwooghene Adeboboye C. Femi Osasere Jude-Kelly Osayawe Abraham Osinuga Ebenezer A. Omojowolo Adekunle F. Adeoye Segun Olapade Ibrahim O. Adelakun Ogundepo D. Moyinoluwa Oluwatosin M. Adeyemo Godfred Y. Scott Ruth A. Ogbonna Emmanuel A. Fajemisin Omama Ehtasham Soyemi Toluwalashe Adetolase A. Bakre Ridwan O. Adesola Seto C. Ogunleye Nnenna R. Anyanwu Terungwa H. Iorkula |
| author_facet | Abdullahi T. Aborode Isreal A. Onifade Mercy M. Olorunshola Gladys O. Adenikinju Ibude J. Aruorivwooghene Adeboboye C. Femi Osasere Jude-Kelly Osayawe Abraham Osinuga Ebenezer A. Omojowolo Adekunle F. Adeoye Segun Olapade Ibrahim O. Adelakun Ogundepo D. Moyinoluwa Oluwatosin M. Adeyemo Godfred Y. Scott Ruth A. Ogbonna Emmanuel A. Fajemisin Omama Ehtasham Soyemi Toluwalashe Adetolase A. Bakre Ridwan O. Adesola Seto C. Ogunleye Nnenna R. Anyanwu Terungwa H. Iorkula |
| author_sort | Abdullahi T. Aborode |
| collection | DOAJ |
| description | Recently, the potential role of vitamins in cancer therapy has attracted considerable research attention. However, the reported findings are inconsistent, with limited information on the biochemical and molecular interactions of different vitamins in various cancer cells. Importantly, the presence of vitamin receptors in tumor cells suggests that vitamins play a significant role in the molecular and biochemical interactions in cancers. Additionally, studies on the efficacy of vitamin supplementation and dosage levels on tumor progression and mortality risk have yielded inconsistent results. Notably, molecular and biochemical investigations have reported the function of vitamins in the proliferation, growth, and invasiveness of tumor cells, as well as in cell cycle arrest and inflammatory signaling. Additionally, different vitamins may regulate the cancer microenvironment by activating various molecular pathways. Vitamins significantly affect immunological function, antioxidant defense, inflammation, and epigenetic control, and can improve treatment outcomes by affecting cell behavior and combating stress and DNA damage. However, further research is necessary to confirm the efficacy of vitamins, establish ideal dosages, and develop effective cancer prevention and treatment plans. Individualized supplementation plans guided by medical knowledge are crucial to achieving optimal results in clinical and preclinical settings. In this review, we critically evaluated the effects of different vitamins on the risk and development of cancer. Additionally, we examined the potential of vitamin supplements to enhance the efficacy of drug therapy and counteract resistance mechanisms that often arise during cancer treatment. |
| format | Article |
| id | doaj-art-76ea5fd32904436eabd7c67928ac15c1 |
| institution | DOAJ |
| issn | 2949-7132 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cancer Pathogenesis and Therapy |
| spelling | doaj-art-76ea5fd32904436eabd7c67928ac15c12025-08-20T02:53:58ZengElsevierCancer Pathogenesis and Therapy2949-71322025-01-013131510.1016/j.cpt.2024.05.001Biochemical mechanisms and molecular interactions of vitamins in cancer therapyAbdullahi T. Aborode0Isreal A. Onifade1Mercy M. Olorunshola2Gladys O. Adenikinju3Ibude J. Aruorivwooghene4Adeboboye C. Femi5Osasere Jude-Kelly Osayawe6Abraham Osinuga7Ebenezer A. Omojowolo8Adekunle F. Adeoye9Segun Olapade10Ibrahim O. Adelakun11Ogundepo D. Moyinoluwa12Oluwatosin M. Adeyemo13Godfred Y. Scott14Ruth A. Ogbonna15Emmanuel A. Fajemisin16Omama Ehtasham17Soyemi Toluwalashe18Adetolase A. Bakre19Ridwan O. Adesola20Seto C. Ogunleye21Nnenna R. Anyanwu22Terungwa H. Iorkula23Department of Chemistry, Mississippi State University, Starkville, MS 39759, USADepartment of Biology, University at Albany, Albany, NY 12222, USADepartment of Biological Sciences, State University of New York at Binghamton, Binghamton, NY 13902, USADepartment of Biological and Environmental Sciences, University of Rhode Island, Kingston, RI 02881, USADepartment of Biological Sciences, University of Kansas Medical Center, Kansas, KS 66103, USADepartment of Microbiology, Federal University of Technology, Akure 340110, NigeriaDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USADepartment of Chemical and Biomolecular Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588, USADepartment of Chemistry, University of Albany, State University of New York, Albany, NY 12222, USADepartment of Mathematics and Statistics, Georgia State University, Atlanta, GA 30302, USADepartment of Chemistry, University of Louisville, Louisville, KY 40208, USADepartment of Chemistry, University of Albany, State University of New York, Albany, NY 12222, USADepartment of Biochemistry, Federal University of Technology, Akure 340110, NigeriaDepartment of Medical Diagnostics, Kwame Nkrumah University of Science and Technology, Kumasi AK385, GhanaDepartment of Medical Diagnostics, Kwame Nkrumah University of Science and Technology, Kumasi AK385, GhanaDepartment of Research and Development, Nasarawa State AIDS and STI Control Program, Nasarawa, Lafia 962101, NigeriaDepartment of Integrative Biomedical Science, University of Cape Town, Cape Town 7701, South AfricaDepartment of Medicine and Surgery, Karachi Medical and Dental College, Karachi 74700, PakistanDepartment of Medicine, Lagos State University College of Medicine, Lagos 10010, NigeriaDepartment of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Ibadan 200005, NigeriaDepartment of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Ibadan 200005, Nigeria; Corresponding author: Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Ibadan 200005, Nigeria.Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Ibadan 200005, NigeriaFaculty of Pharmaceutical Sciences, University of Jos, Plateau, Jos 930003, NigeriaDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USARecently, the potential role of vitamins in cancer therapy has attracted considerable research attention. However, the reported findings are inconsistent, with limited information on the biochemical and molecular interactions of different vitamins in various cancer cells. Importantly, the presence of vitamin receptors in tumor cells suggests that vitamins play a significant role in the molecular and biochemical interactions in cancers. Additionally, studies on the efficacy of vitamin supplementation and dosage levels on tumor progression and mortality risk have yielded inconsistent results. Notably, molecular and biochemical investigations have reported the function of vitamins in the proliferation, growth, and invasiveness of tumor cells, as well as in cell cycle arrest and inflammatory signaling. Additionally, different vitamins may regulate the cancer microenvironment by activating various molecular pathways. Vitamins significantly affect immunological function, antioxidant defense, inflammation, and epigenetic control, and can improve treatment outcomes by affecting cell behavior and combating stress and DNA damage. However, further research is necessary to confirm the efficacy of vitamins, establish ideal dosages, and develop effective cancer prevention and treatment plans. Individualized supplementation plans guided by medical knowledge are crucial to achieving optimal results in clinical and preclinical settings. In this review, we critically evaluated the effects of different vitamins on the risk and development of cancer. Additionally, we examined the potential of vitamin supplements to enhance the efficacy of drug therapy and counteract resistance mechanisms that often arise during cancer treatment.http://www.sciencedirect.com/science/article/pii/S2949713224000302VitaminsCancerBiochemicalMolecular interactionsTherapy |
| spellingShingle | Abdullahi T. Aborode Isreal A. Onifade Mercy M. Olorunshola Gladys O. Adenikinju Ibude J. Aruorivwooghene Adeboboye C. Femi Osasere Jude-Kelly Osayawe Abraham Osinuga Ebenezer A. Omojowolo Adekunle F. Adeoye Segun Olapade Ibrahim O. Adelakun Ogundepo D. Moyinoluwa Oluwatosin M. Adeyemo Godfred Y. Scott Ruth A. Ogbonna Emmanuel A. Fajemisin Omama Ehtasham Soyemi Toluwalashe Adetolase A. Bakre Ridwan O. Adesola Seto C. Ogunleye Nnenna R. Anyanwu Terungwa H. Iorkula Biochemical mechanisms and molecular interactions of vitamins in cancer therapy Cancer Pathogenesis and Therapy Vitamins Cancer Biochemical Molecular interactions Therapy |
| title | Biochemical mechanisms and molecular interactions of vitamins in cancer therapy |
| title_full | Biochemical mechanisms and molecular interactions of vitamins in cancer therapy |
| title_fullStr | Biochemical mechanisms and molecular interactions of vitamins in cancer therapy |
| title_full_unstemmed | Biochemical mechanisms and molecular interactions of vitamins in cancer therapy |
| title_short | Biochemical mechanisms and molecular interactions of vitamins in cancer therapy |
| title_sort | biochemical mechanisms and molecular interactions of vitamins in cancer therapy |
| topic | Vitamins Cancer Biochemical Molecular interactions Therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2949713224000302 |
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