Group A Streptococcus secreted esterase hydrolyzes platelet-activating factor to impede neutrophil recruitment and facilitate innate immune evasion.

Group A Streptococcus secreted esterase hydrolyzes platelet-activating factor to impede neutrophil recruitment and facilitate innate immune evasion.

The innate immune system is the first line of host defense against invading organisms. Thus, pathogens have developed virulence mechanisms to evade the innate immune system. Here, we report a novel means for inhibition of neutrophil recruitment by Group A Streptococcus (GAS). Deletion of the secrete...

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Main Authors: Mengyao Liu, Hui Zhu, Jinquan Li, Cristiana C Garcia, Wenchao Feng, Liliya N Kirpotina, Jonathan Hilmer, Luciana P Tavares, Arthur W Layton, Mark T Quinn, Brian Bothner, Mauro M Teixeira, Benfang Lei
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002624&type=printable
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