Prospective Evaluation of the Pathologic Diagnosis and Treatment Outcomes of Pediatric Burkitt Lymphoma in the Central American Pediatric Hematology-Oncology Association Consortium
PURPOSEClinical and histopathologic diagnosis of pediatric mature B-cell lymphomas (eg, Burkitt lymphoma [BL]) must be accurate to select appropriate risk-based treatment. The Central American Pediatric Hematology-Oncology Association (AHOPCA) in 2000 implemented standardized, resource-adapted treat...
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American Society of Clinical Oncology
2025-04-01
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| Series: | JCO Global Oncology |
| Online Access: | https://ascopubs.org/doi/10.1200/GO-24-00491 |
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| author | Priya Kumar Monika L. Metzger John K. Choi Godwin Job Teresa C. Santiago Armando Peña Miguela A. Caniza Asya Agulnik Pascale Y. Gassant Wendy C. Gómez García Patricia J. Calderón Claudia Garrido Roy Rosado Soad Fuentes Alabí Valentino Conter Meenakshi Devidas Angela K. Carrillo Yichen Chen Paola Friedrich Carlos Rodriguez Galindo Guillermo L. Chantada Victor M. Santana |
| author_facet | Priya Kumar Monika L. Metzger John K. Choi Godwin Job Teresa C. Santiago Armando Peña Miguela A. Caniza Asya Agulnik Pascale Y. Gassant Wendy C. Gómez García Patricia J. Calderón Claudia Garrido Roy Rosado Soad Fuentes Alabí Valentino Conter Meenakshi Devidas Angela K. Carrillo Yichen Chen Paola Friedrich Carlos Rodriguez Galindo Guillermo L. Chantada Victor M. Santana |
| author_sort | Priya Kumar |
| collection | DOAJ |
| description | PURPOSEClinical and histopathologic diagnosis of pediatric mature B-cell lymphomas (eg, Burkitt lymphoma [BL]) must be accurate to select appropriate risk-based treatment. The Central American Pediatric Hematology-Oncology Association (AHOPCA) in 2000 implemented standardized, resource-adapted treatments for these lymphomas. We evaluated the concordance of local histopathologic diagnoses through central review, determined the impact on therapy selection, and described the clinical characteristics and outcomes of pediatric patients with these lymphomas. We suggest recommendations to improve the accuracy of diagnoses.METHODSPathology samples and reports were submitted by six AHOPCA sites to St Jude Children's Research Hospital for central review. The concordance of sample assessments was evaluated using three criteria: histologic diagnosis, morphology, and immunohistochemistry. Clinical characteristics, treatment, and outcomes were also analyzed.RESULTSOf the 68 eligible patients, 53 (78%) received an accurate pathologic diagnosis of BL. For nine (13%) patients, diagnoses changes with therapy implications were made upon central review, while in six patients, there was a minor disagreement with no therapy implications. Most (87%) patients presented with advanced disease. Detailed cellular features were absent in many reports, and immunohistochemistry was routinely performed at only one site. Of the 50 patients whose treatment data were reported, 44 (88%) completed therapy, five died during treatment, and one abandoned treatment. Treatment outcome was satisfactory: 3-year event-free survival was 74% (SE ± 11%), and overall survival was 73% (SE ± 11%).CONCLUSIONPathology laboratories in limited-resource hospitals and regions need further optimization to increase accurate diagnoses of mature B-cell lymphomas. Creating regional pathology networks will enhance diagnostic support. Despite resource limitations and advanced disease at presentation, the AHOPCA sites' adapted treatment strategies have improved patient outcomes. |
| format | Article |
| id | doaj-art-76e8539968164063a4a051d79f82b0b7 |
| institution | DOAJ |
| issn | 2687-8941 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | American Society of Clinical Oncology |
| record_format | Article |
| series | JCO Global Oncology |
| spelling | doaj-art-76e8539968164063a4a051d79f82b0b72025-08-20T03:17:58ZengAmerican Society of Clinical OncologyJCO Global Oncology2687-89412025-04-011110.1200/GO-24-00491Prospective Evaluation of the Pathologic Diagnosis and Treatment Outcomes of Pediatric Burkitt Lymphoma in the Central American Pediatric Hematology-Oncology Association ConsortiumPriya Kumar0Monika L. Metzger1John K. Choi2Godwin Job3Teresa C. Santiago4Armando Peña5Miguela A. Caniza6Asya Agulnik7Pascale Y. Gassant8Wendy C. Gómez García9Patricia J. Calderón10Claudia Garrido11Roy Rosado12Soad Fuentes Alabí13Valentino Conter14Meenakshi Devidas15Angela K. Carrillo16Yichen Chen17Paola Friedrich18Carlos Rodriguez Galindo19Guillermo L. Chantada20Victor M. Santana21Department of Pathology, St Jude Children's Research Hospital, Memphis, TNDepartment of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TNDepartment of Pathology, St Jude Children's Research Hospital, Memphis, TNDepartment of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TNDepartment of Pathology, St Jude Children's Research Hospital, Memphis, TNPediatric Hematology/Oncology Service, Hospital Escuela Universitario, Tegucigalpa, HondurasDepartment of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TNDepartment of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TNDepartment of Pediatric Oncology, Hospital Saint Damien, Port-au-Prince, HaitiDepartment of Oncology, Hospital Infantil Dr Robert Reid Cabral, Santo Domingo, República DominicanaDepartment of Pediatrics, Hematology/Oncology, Hospital Infantil Manuel de Jesus Rivera La Mascota, Managua, NicaraguaDepartment of Pediatrics, Unidad de Oncologia Pediátrica, Francisco Marroquin University, School of Medicine, Guatemala City, GuatemalaDepartment of Pediatrics, Unidad de Oncologia Pediátrica, Francisco Marroquin University, School of Medicine, Guatemala City, GuatemalaDepartment of Pediatric Oncology, Hospital de Niños Benjamin Bloom, San Salvador, El SalvadorPediatric Hemato-Oncology, Fondazione Tettamanti, IRCCS San Gerardo, Monza, ItalyDepartment of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TNDepartment of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TNDepartment of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TNDepartment of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TNDepartment of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TNDepartment of Hematology/Oncology, Institut de Recerca Sant Joan de Deu; Pediatric Cancer Center Barcelona, Hospital Sant Joan de Deu, Barcelona, SpainDepartment of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TNPURPOSEClinical and histopathologic diagnosis of pediatric mature B-cell lymphomas (eg, Burkitt lymphoma [BL]) must be accurate to select appropriate risk-based treatment. The Central American Pediatric Hematology-Oncology Association (AHOPCA) in 2000 implemented standardized, resource-adapted treatments for these lymphomas. We evaluated the concordance of local histopathologic diagnoses through central review, determined the impact on therapy selection, and described the clinical characteristics and outcomes of pediatric patients with these lymphomas. We suggest recommendations to improve the accuracy of diagnoses.METHODSPathology samples and reports were submitted by six AHOPCA sites to St Jude Children's Research Hospital for central review. The concordance of sample assessments was evaluated using three criteria: histologic diagnosis, morphology, and immunohistochemistry. Clinical characteristics, treatment, and outcomes were also analyzed.RESULTSOf the 68 eligible patients, 53 (78%) received an accurate pathologic diagnosis of BL. For nine (13%) patients, diagnoses changes with therapy implications were made upon central review, while in six patients, there was a minor disagreement with no therapy implications. Most (87%) patients presented with advanced disease. Detailed cellular features were absent in many reports, and immunohistochemistry was routinely performed at only one site. Of the 50 patients whose treatment data were reported, 44 (88%) completed therapy, five died during treatment, and one abandoned treatment. Treatment outcome was satisfactory: 3-year event-free survival was 74% (SE ± 11%), and overall survival was 73% (SE ± 11%).CONCLUSIONPathology laboratories in limited-resource hospitals and regions need further optimization to increase accurate diagnoses of mature B-cell lymphomas. Creating regional pathology networks will enhance diagnostic support. Despite resource limitations and advanced disease at presentation, the AHOPCA sites' adapted treatment strategies have improved patient outcomes.https://ascopubs.org/doi/10.1200/GO-24-00491 |
| spellingShingle | Priya Kumar Monika L. Metzger John K. Choi Godwin Job Teresa C. Santiago Armando Peña Miguela A. Caniza Asya Agulnik Pascale Y. Gassant Wendy C. Gómez García Patricia J. Calderón Claudia Garrido Roy Rosado Soad Fuentes Alabí Valentino Conter Meenakshi Devidas Angela K. Carrillo Yichen Chen Paola Friedrich Carlos Rodriguez Galindo Guillermo L. Chantada Victor M. Santana Prospective Evaluation of the Pathologic Diagnosis and Treatment Outcomes of Pediatric Burkitt Lymphoma in the Central American Pediatric Hematology-Oncology Association Consortium JCO Global Oncology |
| title | Prospective Evaluation of the Pathologic Diagnosis and Treatment Outcomes of Pediatric Burkitt Lymphoma in the Central American Pediatric Hematology-Oncology Association Consortium |
| title_full | Prospective Evaluation of the Pathologic Diagnosis and Treatment Outcomes of Pediatric Burkitt Lymphoma in the Central American Pediatric Hematology-Oncology Association Consortium |
| title_fullStr | Prospective Evaluation of the Pathologic Diagnosis and Treatment Outcomes of Pediatric Burkitt Lymphoma in the Central American Pediatric Hematology-Oncology Association Consortium |
| title_full_unstemmed | Prospective Evaluation of the Pathologic Diagnosis and Treatment Outcomes of Pediatric Burkitt Lymphoma in the Central American Pediatric Hematology-Oncology Association Consortium |
| title_short | Prospective Evaluation of the Pathologic Diagnosis and Treatment Outcomes of Pediatric Burkitt Lymphoma in the Central American Pediatric Hematology-Oncology Association Consortium |
| title_sort | prospective evaluation of the pathologic diagnosis and treatment outcomes of pediatric burkitt lymphoma in the central american pediatric hematology oncology association consortium |
| url | https://ascopubs.org/doi/10.1200/GO-24-00491 |
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