Factors Influencing Chemotherapy-Induced Taste Alterations in Cancer Patients Receiving Cisplatin Treatment: A Path Analysis
Introduction Cisplatin is particularly recognized for its adverse effects, most notably its impact on chemosensory perception. Methods This cross-sectional study enrolled 98 cancer patients undergoing cisplatin therapy from April 2022 to December 2023. Patients were administered the Chemotherapy-Ind...
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SAGE Publishing
2025-07-01
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| Series: | Cancer Control |
| Online Access: | https://doi.org/10.1177/10732748251363323 |
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| author | Berna Kurt PhD Berna Ömür Çakmak Öksüzoğlu MD |
| author_facet | Berna Kurt PhD Berna Ömür Çakmak Öksüzoğlu MD |
| author_sort | Berna Kurt PhD |
| collection | DOAJ |
| description | Introduction Cisplatin is particularly recognized for its adverse effects, most notably its impact on chemosensory perception. Methods This cross-sectional study enrolled 98 cancer patients undergoing cisplatin therapy from April 2022 to December 2023. Patients were administered the Chemotherapy-Induced Taste Alteration Scale (CITAS) and the Rhodes Index of Nausea, Vomiting, and Retching (RINVR). Results A multiple linear regression model was employed to determine the effect of taste changes among cancer patients undergoing cisplatin therapy. The study of the model coefficients for the structural model (χ 2 /df = 1.338, P = .004, GFI = 0.955, CFI = 0.986, RMSEA = 0.063, SRMR = 0.079) demonstrated a robust match. This model, formed to evaluate the effects of taste alteration, appetite loss, nausea, vomiting, age, quality of life, and body surface area, was statistically significant and explained 76.4% of the variation. Multiple linear regression evaluations determined significant factors affecting taste alteration associated with nausea-vomiting [(95% CI: 0.111-0.244); P = 0.042], loss of appetite [(95% CI: 0.102-0.254); P = 0.000], age [(95% CI: −0.827-0.424); P = 0.001], quality of life [(95% CI: −0.908-0.489); P = 0.000], and body surface area [(95% CI: 0.024-0.098); P = 0.021]. Conclusion Taste alteration significantly influenced symptoms of appetite loss, nausea, vomiting, age, and body surface area. These results provide valuable insights for developing effective intervention strategies to alleviate the relational effects of symptom clusters on patients’ quality of life and symptoms, particularly for cancer patients receiving cisplatin therapy. |
| format | Article |
| id | doaj-art-76e685e54c0340d89eab5dab073e71b3 |
| institution | DOAJ |
| issn | 1526-2359 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cancer Control |
| spelling | doaj-art-76e685e54c0340d89eab5dab073e71b32025-08-20T02:48:02ZengSAGE PublishingCancer Control1526-23592025-07-013210.1177/10732748251363323Factors Influencing Chemotherapy-Induced Taste Alterations in Cancer Patients Receiving Cisplatin Treatment: A Path AnalysisBerna Kurt PhDBerna Ömür Çakmak Öksüzoğlu MDIntroduction Cisplatin is particularly recognized for its adverse effects, most notably its impact on chemosensory perception. Methods This cross-sectional study enrolled 98 cancer patients undergoing cisplatin therapy from April 2022 to December 2023. Patients were administered the Chemotherapy-Induced Taste Alteration Scale (CITAS) and the Rhodes Index of Nausea, Vomiting, and Retching (RINVR). Results A multiple linear regression model was employed to determine the effect of taste changes among cancer patients undergoing cisplatin therapy. The study of the model coefficients for the structural model (χ 2 /df = 1.338, P = .004, GFI = 0.955, CFI = 0.986, RMSEA = 0.063, SRMR = 0.079) demonstrated a robust match. This model, formed to evaluate the effects of taste alteration, appetite loss, nausea, vomiting, age, quality of life, and body surface area, was statistically significant and explained 76.4% of the variation. Multiple linear regression evaluations determined significant factors affecting taste alteration associated with nausea-vomiting [(95% CI: 0.111-0.244); P = 0.042], loss of appetite [(95% CI: 0.102-0.254); P = 0.000], age [(95% CI: −0.827-0.424); P = 0.001], quality of life [(95% CI: −0.908-0.489); P = 0.000], and body surface area [(95% CI: 0.024-0.098); P = 0.021]. Conclusion Taste alteration significantly influenced symptoms of appetite loss, nausea, vomiting, age, and body surface area. These results provide valuable insights for developing effective intervention strategies to alleviate the relational effects of symptom clusters on patients’ quality of life and symptoms, particularly for cancer patients receiving cisplatin therapy.https://doi.org/10.1177/10732748251363323 |
| spellingShingle | Berna Kurt PhD Berna Ömür Çakmak Öksüzoğlu MD Factors Influencing Chemotherapy-Induced Taste Alterations in Cancer Patients Receiving Cisplatin Treatment: A Path Analysis Cancer Control |
| title | Factors Influencing Chemotherapy-Induced Taste Alterations in Cancer Patients Receiving Cisplatin Treatment: A Path Analysis |
| title_full | Factors Influencing Chemotherapy-Induced Taste Alterations in Cancer Patients Receiving Cisplatin Treatment: A Path Analysis |
| title_fullStr | Factors Influencing Chemotherapy-Induced Taste Alterations in Cancer Patients Receiving Cisplatin Treatment: A Path Analysis |
| title_full_unstemmed | Factors Influencing Chemotherapy-Induced Taste Alterations in Cancer Patients Receiving Cisplatin Treatment: A Path Analysis |
| title_short | Factors Influencing Chemotherapy-Induced Taste Alterations in Cancer Patients Receiving Cisplatin Treatment: A Path Analysis |
| title_sort | factors influencing chemotherapy induced taste alterations in cancer patients receiving cisplatin treatment a path analysis |
| url | https://doi.org/10.1177/10732748251363323 |
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