Delivery of oligonucleotide‐based therapeutics: challenges and opportunities

Delivery of oligonucleotide‐based therapeutics: challenges and opportunities

Abstract Nucleic acid‐based therapeutics that regulate gene expression have been developed towards clinical use at a steady pace for several decades, but in recent years the field has been accelerating. To date, there are 11 marketed products based on antisense oligonucleotides, aptamers and small i...

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Main Authors: Suzan M Hammond, Annemieke Aartsma‐Rus, Sandra Alves, Sven E Borgos, Ronald A M Buijsen, Rob W J Collin, Giuseppina Covello, Michela A Denti, Lourdes R Desviat, Lucía Echevarría, Camilla Foged, Gisela Gaina, Alejandro Garanto, Aurelie T Goyenvalle, Magdalena Guzowska, Irina Holodnuka, David R Jones, Sabine Krause, Taavi Lehto, Marisol Montolio, Willeke Van Roon‐Mom, Virginia Arechavala‐Gomeza
Format: Article
Language:English
Published: Springer Nature 2021-04-01
Series:EMBO Molecular Medicine
Subjects:
delivery
oligonucleotides
preclinical models
RNA therapeutics
safety
Online Access:https://doi.org/10.15252/emmm.202013243
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