Spectrophotometric Determination of Methyl Paraben in Pharmaceutical Formulations by Oxidative Coupling Reaction
A simple and sensitive spectrophotometric method was developed for the determination of Methyl Paraben via oxidative coupling with the 2,4-Dinitrophynel hydrazine in the presence of N-bromosuccinimid in a basic medium, Absorbance of the obtained coloured products was measured at the corresponding...
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| Format: | Article |
| Language: | English |
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Tikrit University
2023-02-01
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| Series: | Tikrit Journal of Pure Science |
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| Online Access: | https://tjpsj.org/index.php/tjps/article/view/1085 |
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| author | Abdul Majeed Khorsheed Ahmed Abdulla Salim Khazaal Alyea Hussain Ahmed |
| author_facet | Abdul Majeed Khorsheed Ahmed Abdulla Salim Khazaal Alyea Hussain Ahmed |
| author_sort | Abdul Majeed Khorsheed Ahmed |
| collection | DOAJ |
| description |
A simple and sensitive spectrophotometric method was developed for the determination of Methyl Paraben via oxidative coupling with the 2,4-Dinitrophynel hydrazine in the presence of N-bromosuccinimid in a basic medium, Absorbance of the obtained coloured products was measured at the corresponding optimum wavelengths (600 nm), Beer’s law is obeyed over the concentration of 2.0-20 μg.ml-1, and The molar absorptivity of (6253 L.mole-1.cm-1), Sandell,s sensitity index of (0.02433 µg.cm-2). The detection limits were (0.34 μg.ml-1), with a linear regression correlation coefficient of (0.9947) and recovery range from (98.96–103%). The proposed method has been applied successfully to determine Methyl Paraben in pharmaceutical preparations and cosmetic formulations.
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| format | Article |
| id | doaj-art-76e35e585abd4869825fb651fe77c6e7 |
| institution | OA Journals |
| issn | 1813-1662 2415-1726 |
| language | English |
| publishDate | 2023-02-01 |
| publisher | Tikrit University |
| record_format | Article |
| series | Tikrit Journal of Pure Science |
| spelling | doaj-art-76e35e585abd4869825fb651fe77c6e72025-08-20T02:36:27ZengTikrit UniversityTikrit Journal of Pure Science1813-16622415-17262023-02-0121610.25130/tjps.v21i6.1085Spectrophotometric Determination of Methyl Paraben in Pharmaceutical Formulations by Oxidative Coupling ReactionAbdul Majeed Khorsheed AhmedAbdulla Salim KhazaalAlyea Hussain Ahmed A simple and sensitive spectrophotometric method was developed for the determination of Methyl Paraben via oxidative coupling with the 2,4-Dinitrophynel hydrazine in the presence of N-bromosuccinimid in a basic medium, Absorbance of the obtained coloured products was measured at the corresponding optimum wavelengths (600 nm), Beer’s law is obeyed over the concentration of 2.0-20 μg.ml-1, and The molar absorptivity of (6253 L.mole-1.cm-1), Sandell,s sensitity index of (0.02433 µg.cm-2). The detection limits were (0.34 μg.ml-1), with a linear regression correlation coefficient of (0.9947) and recovery range from (98.96–103%). The proposed method has been applied successfully to determine Methyl Paraben in pharmaceutical preparations and cosmetic formulations. https://tjpsj.org/index.php/tjps/article/view/1085SpectrophotometricMethyl Paraben |
| spellingShingle | Abdul Majeed Khorsheed Ahmed Abdulla Salim Khazaal Alyea Hussain Ahmed Spectrophotometric Determination of Methyl Paraben in Pharmaceutical Formulations by Oxidative Coupling Reaction Tikrit Journal of Pure Science Spectrophotometric Methyl Paraben |
| title | Spectrophotometric Determination of Methyl Paraben in Pharmaceutical Formulations by Oxidative Coupling Reaction |
| title_full | Spectrophotometric Determination of Methyl Paraben in Pharmaceutical Formulations by Oxidative Coupling Reaction |
| title_fullStr | Spectrophotometric Determination of Methyl Paraben in Pharmaceutical Formulations by Oxidative Coupling Reaction |
| title_full_unstemmed | Spectrophotometric Determination of Methyl Paraben in Pharmaceutical Formulations by Oxidative Coupling Reaction |
| title_short | Spectrophotometric Determination of Methyl Paraben in Pharmaceutical Formulations by Oxidative Coupling Reaction |
| title_sort | spectrophotometric determination of methyl paraben in pharmaceutical formulations by oxidative coupling reaction |
| topic | Spectrophotometric Methyl Paraben |
| url | https://tjpsj.org/index.php/tjps/article/view/1085 |
| work_keys_str_mv | AT abdulmajeedkhorsheedahmed spectrophotometricdeterminationofmethylparabeninpharmaceuticalformulationsbyoxidativecouplingreaction AT abdullasalimkhazaal spectrophotometricdeterminationofmethylparabeninpharmaceuticalformulationsbyoxidativecouplingreaction AT alyeahussainahmed spectrophotometricdeterminationofmethylparabeninpharmaceuticalformulationsbyoxidativecouplingreaction |