Effect of ovarian dysfunction induced ovariectomy and Porphyromonas gingivalis induction to risk of metabolic syndrome: in vivo study
Periodontal diseases and metabolic syndrome are related to complicated multifactorial conditions. However, the relationship is not yet evident. Estrogen insufficiency might correlate to this condition, possibly caused by ovarian removal and Porphyromonas gingivalis (P. gingivalis) infection. This s...
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| Format: | Article |
| Language: | English |
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Universidade Estadual Paulista
2024-06-01
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| Series: | Brazilian Dental Science |
| Online Access: | https://ojs.ict.unesp.br/index.php/cob/article/view/3880 |
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| author | Agustin Wulan Suci-Dharmayanti Zahara Meilawaty Tantin Ermawati Agus Murdojohadi Putradjaka Zahreni Hamzah |
| author_facet | Agustin Wulan Suci-Dharmayanti Zahara Meilawaty Tantin Ermawati Agus Murdojohadi Putradjaka Zahreni Hamzah |
| author_sort | Agustin Wulan Suci-Dharmayanti |
| collection | DOAJ |
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Periodontal diseases and metabolic syndrome are related to complicated multifactorial conditions. However, the relationship is not yet evident. Estrogen insufficiency might correlate to this condition, possibly caused by ovarian removal and Porphyromonas gingivalis (P. gingivalis) infection. This study aimed to evaluate the effect of ovarian dysfunction caused by ovariectomy and P. gingivalis infection to metabolic syndrome development. This study was an experimental laboratory study using female rats Sprague Dawley Strain. Animal models were divided into four groups: control, ovariectomy (OVX), ovariectomy-periodontitis (OPG), and periodontitis (PG). The purpose of every treatment in each group was to induce ovarian dysfunction. The OVX group was undertaken ovaries removal surgery. PG was performed P. gingivalis induction. Therefore OPG was a combination of ovariectomy and P. gingivalis induction. Blood was drawn and observed on days 0, 3, 7, 14, 21, and 28. The blood sample was examined for uric acid, cholesterol, glucose and estrogen. The collected data were all statistically examined. All treatment groups presented body weight and blood biochemical observation significantly higher than the control group, except total cholesterol (p<0.05). Moreover, most variables presented a correlation between groups to body weight and biochemical blood indicators, except blood uric acid level (R>0.5). The metabolic syndrome was triggered by ovarian dysfunction brought on by P. gingivalis infection after ovariectomy. They both took the same risk. Even P. gingivalis induction made metabolic syndrome in the group of animal models which underwent ovariectomy worse.
KEYWORDS
Estrogen deficiency; Metabolic syndrome; Ovariectomy; Ovarian dysfunction; P. gingivalis.
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| format | Article |
| id | doaj-art-76e2aa5348fc4c33a3b647990442cd40 |
| institution | Kabale University |
| issn | 2178-6011 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Universidade Estadual Paulista |
| record_format | Article |
| series | Brazilian Dental Science |
| spelling | doaj-art-76e2aa5348fc4c33a3b647990442cd402025-08-22T14:49:11ZengUniversidade Estadual PaulistaBrazilian Dental Science2178-60112024-06-0127110.4322/bds.2024.e3880Effect of ovarian dysfunction induced ovariectomy and Porphyromonas gingivalis induction to risk of metabolic syndrome: in vivo studyAgustin Wulan Suci-Dharmayanti0https://orcid.org/0000-0003-3037-7055Zahara Meilawaty1https://orcid.org/0000-0001-7709-4576Tantin Ermawati2https://orcid.org/0000-0002-0322-8997Agus Murdojohadi Putradjaka3https://orcid.org/0009-0006-2261-8647Zahreni Hamzah4https://orcid.org/0000-0001-5101-0872Universitas Jember, Biomedical Department, Faculty of Dentistry. Jember, Indonesia.Universitas Jember, Biomedical Department, Faculty of Dentistry. Jember, Indonesia.Universitas Jember, Biomedical Department, Faculty of Dentistry. Jember, Indonesia.Universitas Jember, Biomedical Department, Faculty of Dentistry. Jember, Indonesia.Universitas Jember, Biomedical Department, Faculty of Dentistry. Jember, Indonesia. Periodontal diseases and metabolic syndrome are related to complicated multifactorial conditions. However, the relationship is not yet evident. Estrogen insufficiency might correlate to this condition, possibly caused by ovarian removal and Porphyromonas gingivalis (P. gingivalis) infection. This study aimed to evaluate the effect of ovarian dysfunction caused by ovariectomy and P. gingivalis infection to metabolic syndrome development. This study was an experimental laboratory study using female rats Sprague Dawley Strain. Animal models were divided into four groups: control, ovariectomy (OVX), ovariectomy-periodontitis (OPG), and periodontitis (PG). The purpose of every treatment in each group was to induce ovarian dysfunction. The OVX group was undertaken ovaries removal surgery. PG was performed P. gingivalis induction. Therefore OPG was a combination of ovariectomy and P. gingivalis induction. Blood was drawn and observed on days 0, 3, 7, 14, 21, and 28. The blood sample was examined for uric acid, cholesterol, glucose and estrogen. The collected data were all statistically examined. All treatment groups presented body weight and blood biochemical observation significantly higher than the control group, except total cholesterol (p<0.05). Moreover, most variables presented a correlation between groups to body weight and biochemical blood indicators, except blood uric acid level (R>0.5). The metabolic syndrome was triggered by ovarian dysfunction brought on by P. gingivalis infection after ovariectomy. They both took the same risk. Even P. gingivalis induction made metabolic syndrome in the group of animal models which underwent ovariectomy worse. KEYWORDS Estrogen deficiency; Metabolic syndrome; Ovariectomy; Ovarian dysfunction; P. gingivalis. https://ojs.ict.unesp.br/index.php/cob/article/view/3880 |
| spellingShingle | Agustin Wulan Suci-Dharmayanti Zahara Meilawaty Tantin Ermawati Agus Murdojohadi Putradjaka Zahreni Hamzah Effect of ovarian dysfunction induced ovariectomy and Porphyromonas gingivalis induction to risk of metabolic syndrome: in vivo study Brazilian Dental Science |
| title | Effect of ovarian dysfunction induced ovariectomy and Porphyromonas gingivalis induction to risk of metabolic syndrome: in vivo study |
| title_full | Effect of ovarian dysfunction induced ovariectomy and Porphyromonas gingivalis induction to risk of metabolic syndrome: in vivo study |
| title_fullStr | Effect of ovarian dysfunction induced ovariectomy and Porphyromonas gingivalis induction to risk of metabolic syndrome: in vivo study |
| title_full_unstemmed | Effect of ovarian dysfunction induced ovariectomy and Porphyromonas gingivalis induction to risk of metabolic syndrome: in vivo study |
| title_short | Effect of ovarian dysfunction induced ovariectomy and Porphyromonas gingivalis induction to risk of metabolic syndrome: in vivo study |
| title_sort | effect of ovarian dysfunction induced ovariectomy and porphyromonas gingivalis induction to risk of metabolic syndrome in vivo study |
| url | https://ojs.ict.unesp.br/index.php/cob/article/view/3880 |
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