The CD27L and CTP1L endolysins targeting Clostridia contain a built-in trigger and release factor.

The CD27L and CTP1L endolysins targeting Clostridia contain a built-in trigger and release factor.

The bacteriophage ΦCD27 is capable of lysing Clostridium difficile, a pathogenic bacterium that is a major cause for nosocomial infection. A recombinant CD27L endolysin lyses C. difficile in vitro, and represents a promising alternative as a bactericide. To better understand the lysis mechanism, we...

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Bibliographic Details
Main Authors: Matthew Dunne, Haydyn D T Mertens, Vasiliki Garefalaki, Cy M Jeffries, Andrew Thompson, Edward A Lemke, Dmitri I Svergun, Melinda J Mayer, Arjan Narbad, Rob Meijers
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-07-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004228&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004228&type=printable

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