beta-cell transplantation in diabetes mellitus
Patients with diabetes mellitus suffer either from destruction of pancreatic beta-cells or progressive deterioration of their function. Thus, transplantation of an intact beta-cell population fully capable of insulin secretion is the only means to cure this disease. Despite glycemic benefits and dec...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2013-09-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/812 |
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| author | S Pellegrini V Sordi L Piemonti |
| author_facet | S Pellegrini V Sordi L Piemonti |
| author_sort | S Pellegrini |
| collection | DOAJ |
| description | Patients with diabetes mellitus suffer either from destruction of pancreatic beta-cells or progressive deterioration of their function. Thus, transplantation of an intact beta-cell population fully capable of insulin secretion is the only means to cure this disease. Despite glycemic benefits and decrease in risks for late complications, islet transplantation or complete pancreatic grafting in humans remains a challenge due to necessity of lifetime immunosuppression and increasingly sparse donor resources. Current paper presents a review of modern endeavours to obtain a limitless source for glucose-sensitive insulin secreting cells. We discuss, in particular, complex aspects of beta-cell proliferation and/or neogenesis in vivo, issues with xenogenous pancreatic islets, and latest advances in controlled differentiation of embryonic and induced polypotent stem cells ? the most promising and relevant source of beta-cells. |
| format | Article |
| id | doaj-art-76dfb75ea27948bab0c8ccd6c9bf1906 |
| institution | Kabale University |
| issn | 2072-0351 2072-0378 |
| language | English |
| publishDate | 2013-09-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj-art-76dfb75ea27948bab0c8ccd6c9bf19062025-08-20T03:47:54ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782013-09-01163112010.14341/2072-0351-812792beta-cell transplantation in diabetes mellitusS Pellegrini0V Sordi1L Piemonti2Diabetes Research Institue, Ospidale San Raffaele, Milano; Universita degli Studi dell'Insubria, Varese, ItalyDiabetes Research Institue, Ospidale San Raffaele, Milano, ItalyDiabetes Research Institue, Ospidale San Raffaele, Milano, ItalyPatients with diabetes mellitus suffer either from destruction of pancreatic beta-cells or progressive deterioration of their function. Thus, transplantation of an intact beta-cell population fully capable of insulin secretion is the only means to cure this disease. Despite glycemic benefits and decrease in risks for late complications, islet transplantation or complete pancreatic grafting in humans remains a challenge due to necessity of lifetime immunosuppression and increasingly sparse donor resources. Current paper presents a review of modern endeavours to obtain a limitless source for glucose-sensitive insulin secreting cells. We discuss, in particular, complex aspects of beta-cell proliferation and/or neogenesis in vivo, issues with xenogenous pancreatic islets, and latest advances in controlled differentiation of embryonic and induced polypotent stem cells ? the most promising and relevant source of beta-cells.https://www.dia-endojournals.ru/jour/article/view/812diabetes melliruspancreatic beta-cellsproliferationstem cells |
| spellingShingle | S Pellegrini V Sordi L Piemonti beta-cell transplantation in diabetes mellitus Сахарный диабет diabetes mellirus pancreatic beta-cells proliferation stem cells |
| title | beta-cell transplantation in diabetes mellitus |
| title_full | beta-cell transplantation in diabetes mellitus |
| title_fullStr | beta-cell transplantation in diabetes mellitus |
| title_full_unstemmed | beta-cell transplantation in diabetes mellitus |
| title_short | beta-cell transplantation in diabetes mellitus |
| title_sort | beta cell transplantation in diabetes mellitus |
| topic | diabetes mellirus pancreatic beta-cells proliferation stem cells |
| url | https://www.dia-endojournals.ru/jour/article/view/812 |
| work_keys_str_mv | AT spellegrini betacelltransplantationindiabetesmellitus AT vsordi betacelltransplantationindiabetesmellitus AT lpiemonti betacelltransplantationindiabetesmellitus |