Channels, Transporters, and Receptors at Membrane Contact Sites
Membrane contact sites (MCSs) are specialized regions where two or more organelle membranes come into close apposition, typically separated by only 10–30 nm, while remaining distinct and unfused. These sites play crucial roles in cellular homeostasis, signaling, and metabolism. This review focuses o...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2024-12-01
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| Online Access: | https://doi.org/10.1177/25152564241305593 |
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| author | Maria Casas Eamonn James Dickson |
| author_facet | Maria Casas Eamonn James Dickson |
| author_sort | Maria Casas |
| collection | DOAJ |
| description | Membrane contact sites (MCSs) are specialized regions where two or more organelle membranes come into close apposition, typically separated by only 10–30 nm, while remaining distinct and unfused. These sites play crucial roles in cellular homeostasis, signaling, and metabolism. This review focuses on ion channels, transporters, and receptors localized to MCSs, with particular emphasis on those associated with the plasma membrane and endoplasmic reticulum (ER). We discuss the molecular composition and functional significance of these proteins in shaping both organelle and cellular functions, highlighting their importance in excitable cells and their influence on intracellular calcium signaling. Key MCSs examined include ER–plasma membrane, ER–mitochondria, and ER–lysosome contacts. This review addresses our current knowledge of the ion channels found within these contacts, the dynamic regulation of MCSs, their importance in various physiological processes, and their potential implications in pathological conditions. |
| format | Article |
| id | doaj-art-76ded07498e54e8ea77192fa10bdf969 |
| institution | DOAJ |
| issn | 2515-2564 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Contact |
| spelling | doaj-art-76ded07498e54e8ea77192fa10bdf9692025-08-20T02:57:25ZengSAGE PublishingContact2515-25642024-12-01710.1177/25152564241305593Channels, Transporters, and Receptors at Membrane Contact SitesMaria CasasEamonn James DicksonMembrane contact sites (MCSs) are specialized regions where two or more organelle membranes come into close apposition, typically separated by only 10–30 nm, while remaining distinct and unfused. These sites play crucial roles in cellular homeostasis, signaling, and metabolism. This review focuses on ion channels, transporters, and receptors localized to MCSs, with particular emphasis on those associated with the plasma membrane and endoplasmic reticulum (ER). We discuss the molecular composition and functional significance of these proteins in shaping both organelle and cellular functions, highlighting their importance in excitable cells and their influence on intracellular calcium signaling. Key MCSs examined include ER–plasma membrane, ER–mitochondria, and ER–lysosome contacts. This review addresses our current knowledge of the ion channels found within these contacts, the dynamic regulation of MCSs, their importance in various physiological processes, and their potential implications in pathological conditions.https://doi.org/10.1177/25152564241305593 |
| spellingShingle | Maria Casas Eamonn James Dickson Channels, Transporters, and Receptors at Membrane Contact Sites Contact |
| title | Channels, Transporters, and Receptors at Membrane Contact Sites |
| title_full | Channels, Transporters, and Receptors at Membrane Contact Sites |
| title_fullStr | Channels, Transporters, and Receptors at Membrane Contact Sites |
| title_full_unstemmed | Channels, Transporters, and Receptors at Membrane Contact Sites |
| title_short | Channels, Transporters, and Receptors at Membrane Contact Sites |
| title_sort | channels transporters and receptors at membrane contact sites |
| url | https://doi.org/10.1177/25152564241305593 |
| work_keys_str_mv | AT mariacasas channelstransportersandreceptorsatmembranecontactsites AT eamonnjamesdickson channelstransportersandreceptorsatmembranecontactsites |