The colonic mucosal virome in inflammatory bowel disease reveals Crassvirales depletion and disease-specific virome features
The mucosal virome is increasingly recognized for its potential role in shaping intestinal health and disease. Building on previous findings, we analyzed the mucosal virome from 51 individuals, including newly diagnosed treatment naïve participants with ulcerative colitis (UC), Crohn’s disease (CD),...
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Taylor & Francis Group
2025-12-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2025.2539450 |
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| author | Austin Yan James Butcher David R. Mack Alain Stintzi |
| author_facet | Austin Yan James Butcher David R. Mack Alain Stintzi |
| author_sort | Austin Yan |
| collection | DOAJ |
| description | The mucosal virome is increasingly recognized for its potential role in shaping intestinal health and disease. Building on previous findings, we analyzed the mucosal virome from 51 individuals, including newly diagnosed treatment naïve participants with ulcerative colitis (UC), Crohn’s disease (CD), and non-inflammatory bowel disease (non-IBD) controls, incorporating longitudinal sampling for a subset of the participants. Viromes were highly individualized, with no shared or core components across participants. Unlike fecal virome studies, we observed no significant associations between mucosal virome diversity and mucosal inflammation, disease subtype, or sampling site. However, there was positive correlation between virome and bacteriome diversity, particularly in CD, suggesting the presence of dynamic interactions that influence microbial community structure. Crassvirales was abundant in the mucosa layer and, consistent with prior studies, Crassvirales abundance was reduced in IBD, irrespective of inflammation status or IBD subtype. These findings highlight their potential as biomarkers of virome health. Our data also revealed the potential presence of altered bacteriome-virome interactions and longitudinal sampling revealed a persistent subset of viruses, potentially shaping disease progression and remission dynamics. Our study underscores the importance of distinguishing microbial community dynamics across IBD subtypes and highlights Crassvirales as key players in mucosal immunity. |
| format | Article |
| id | doaj-art-76d980419496463d87ed2e950da5eeaf |
| institution | Kabale University |
| issn | 1949-0976 1949-0984 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
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| series | Gut Microbes |
| spelling | doaj-art-76d980419496463d87ed2e950da5eeaf2025-08-20T03:43:14ZengTaylor & Francis GroupGut Microbes1949-09761949-09842025-12-0117110.1080/19490976.2025.2539450The colonic mucosal virome in inflammatory bowel disease reveals Crassvirales depletion and disease-specific virome featuresAustin Yan0James Butcher1David R. Mack2Alain Stintzi3Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, CanadaDepartment of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, CanadaDepartment of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa, ON, CanadaDepartment of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, CanadaThe mucosal virome is increasingly recognized for its potential role in shaping intestinal health and disease. Building on previous findings, we analyzed the mucosal virome from 51 individuals, including newly diagnosed treatment naïve participants with ulcerative colitis (UC), Crohn’s disease (CD), and non-inflammatory bowel disease (non-IBD) controls, incorporating longitudinal sampling for a subset of the participants. Viromes were highly individualized, with no shared or core components across participants. Unlike fecal virome studies, we observed no significant associations between mucosal virome diversity and mucosal inflammation, disease subtype, or sampling site. However, there was positive correlation between virome and bacteriome diversity, particularly in CD, suggesting the presence of dynamic interactions that influence microbial community structure. Crassvirales was abundant in the mucosa layer and, consistent with prior studies, Crassvirales abundance was reduced in IBD, irrespective of inflammation status or IBD subtype. These findings highlight their potential as biomarkers of virome health. Our data also revealed the potential presence of altered bacteriome-virome interactions and longitudinal sampling revealed a persistent subset of viruses, potentially shaping disease progression and remission dynamics. Our study underscores the importance of distinguishing microbial community dynamics across IBD subtypes and highlights Crassvirales as key players in mucosal immunity.https://www.tandfonline.com/doi/10.1080/19490976.2025.2539450Viromegut microbiomeinflammatory bowel diseasegut mucosa |
| spellingShingle | Austin Yan James Butcher David R. Mack Alain Stintzi The colonic mucosal virome in inflammatory bowel disease reveals Crassvirales depletion and disease-specific virome features Gut Microbes Virome gut microbiome inflammatory bowel disease gut mucosa |
| title | The colonic mucosal virome in inflammatory bowel disease reveals Crassvirales depletion and disease-specific virome features |
| title_full | The colonic mucosal virome in inflammatory bowel disease reveals Crassvirales depletion and disease-specific virome features |
| title_fullStr | The colonic mucosal virome in inflammatory bowel disease reveals Crassvirales depletion and disease-specific virome features |
| title_full_unstemmed | The colonic mucosal virome in inflammatory bowel disease reveals Crassvirales depletion and disease-specific virome features |
| title_short | The colonic mucosal virome in inflammatory bowel disease reveals Crassvirales depletion and disease-specific virome features |
| title_sort | colonic mucosal virome in inflammatory bowel disease reveals crassvirales depletion and disease specific virome features |
| topic | Virome gut microbiome inflammatory bowel disease gut mucosa |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2025.2539450 |
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