Engineering extracellular matrix-based hydrogels for intervertebral disc regeneration

Engineering extracellular matrix-based hydrogels for intervertebral disc regeneration

Lower back pain (LBP) is a major health concern, especially in older adults. A key aetiological factor is intervertebral disc (IVD) degeneration. It is mediated by dysregulation of extracellular matrix (ECM) and inflammation. In recent years, regenerative therapies have garnered attention for their...

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Bibliographic Details
Main Authors: Mwafaq Kmail, Rusydi Razak, Isma Liza Mohd Isa
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
intervertebral disc degeneration
lower back pain
hydrogel
extracellular matrix
biomaterials
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1601154/full
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