Spatial mechanisms of quality control during chaperone-mediated assembly of the proteasome
Abstract Cellular protein degradation requires a complex molecular machine, the proteasome. To mitigate the fundamental challenge of assembling the 66-subunit proteasome, cells utilize dedicated chaperones to order subunit addition. However, recent evidence suggests that proteasome assembly is not s...
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| Main Authors: | Eshita Das, Linh Le, Vladyslava Sokolova, James D. Orth, Soyeon Park |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-04-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-58703-8 |
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