Tacrolimus for Ophthalmic Use: An Update
Tacrolimus, a macrolide isolated from a strain of Streptomyces, is an immunosuppressant and is used in cases of organ transplantation. It has a mechanism of action similar to that of cyclosporine. It is a lipophilic molecule which blocks the early phase of T-cell activation, thus inhibiting both T-l...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2013-01-01
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| Series: | Delhi Journal of Ophthalmology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.7869/djo.2012.72 |
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| Summary: | Tacrolimus, a macrolide isolated from a strain of Streptomyces, is an immunosuppressant and is used in cases of organ transplantation. It has a mechanism of action similar to that of cyclosporine. It is a lipophilic molecule which blocks the early phase of T-cell activation, thus inhibiting both T-lymphocyte signal transduction and IL-2 transcription. It is also inhibits the release of histamine from mast cells and impairs prostaglandin synthesis. Tacrolimus has shown to be effective in the treatment of immune-mediated diseases such as corneal graft rejection, ocular inflammation, ocular pemphigoid, and uveitis. In this article, we have tried to update the uses of tacrolimus in ophthalmology. |
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| ISSN: | 0972-0200 2454-2784 |