A Child with Local Lipohypertrophy following Recombinant Human Growth Hormone Administration
Local lipohypertrophy due to recombinant human growth hormone (rhGH) administration is a rare phenomenon. Here, we report a case of an 11-year-old girl who presented with a paraumbilical swelling, approximately one year after the start of rhGH treatment for short stature due to the presumed diagnosi...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2016/9648043 |
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| author | Ilan J. N. Koppen Roel Bakx Chris C. de Kruiff A. S. Paul van Trotsenburg |
| author_facet | Ilan J. N. Koppen Roel Bakx Chris C. de Kruiff A. S. Paul van Trotsenburg |
| author_sort | Ilan J. N. Koppen |
| collection | DOAJ |
| description | Local lipohypertrophy due to recombinant human growth hormone (rhGH) administration is a rare phenomenon. Here, we report a case of an 11-year-old girl who presented with a paraumbilical swelling, approximately one year after the start of rhGH treatment for short stature due to the presumed diagnosis of partial growth hormone insensitivity. Ultrasound imaging revealed an asymmetric distribution of subcutaneous fat tissue at the rhGH administration site, indicating local lipohypertrophy. After sparing her routine injection site and alternating other sites, the swelling disappeared within 6 months. Although the precise cause of local lipohypertrophy resulting from rhGH administration is still unclear, it might be related to the presumed diagnosis of partial growth hormone insensitivity. |
| format | Article |
| id | doaj-art-76d0d0fa273e4613922565ea02ac0927 |
| institution | Kabale University |
| issn | 2090-6803 2090-6811 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-76d0d0fa273e4613922565ea02ac09272025-08-20T03:35:15ZengWileyCase Reports in Pediatrics2090-68032090-68112016-01-01201610.1155/2016/96480439648043A Child with Local Lipohypertrophy following Recombinant Human Growth Hormone AdministrationIlan J. N. Koppen0Roel Bakx1Chris C. de Kruiff2A. S. Paul van Trotsenburg3Department of Pediatric Gastroenterology, Emma Children’s Hospital, Academic Medical Center, Amsterdam, NetherlandsPediatric Surgical Centre Amsterdam, VUMC/Emma Children’s Hospital, Academic Medical Center, Amsterdam, NetherlandsDepartment of Pediatric Endocrinology, Emma Children’s Hospital, Academic Medical Center, Amsterdam, NetherlandsDepartment of Pediatric Endocrinology, Emma Children’s Hospital, Academic Medical Center, Amsterdam, NetherlandsLocal lipohypertrophy due to recombinant human growth hormone (rhGH) administration is a rare phenomenon. Here, we report a case of an 11-year-old girl who presented with a paraumbilical swelling, approximately one year after the start of rhGH treatment for short stature due to the presumed diagnosis of partial growth hormone insensitivity. Ultrasound imaging revealed an asymmetric distribution of subcutaneous fat tissue at the rhGH administration site, indicating local lipohypertrophy. After sparing her routine injection site and alternating other sites, the swelling disappeared within 6 months. Although the precise cause of local lipohypertrophy resulting from rhGH administration is still unclear, it might be related to the presumed diagnosis of partial growth hormone insensitivity.http://dx.doi.org/10.1155/2016/9648043 |
| spellingShingle | Ilan J. N. Koppen Roel Bakx Chris C. de Kruiff A. S. Paul van Trotsenburg A Child with Local Lipohypertrophy following Recombinant Human Growth Hormone Administration Case Reports in Pediatrics |
| title | A Child with Local Lipohypertrophy following Recombinant Human Growth Hormone Administration |
| title_full | A Child with Local Lipohypertrophy following Recombinant Human Growth Hormone Administration |
| title_fullStr | A Child with Local Lipohypertrophy following Recombinant Human Growth Hormone Administration |
| title_full_unstemmed | A Child with Local Lipohypertrophy following Recombinant Human Growth Hormone Administration |
| title_short | A Child with Local Lipohypertrophy following Recombinant Human Growth Hormone Administration |
| title_sort | child with local lipohypertrophy following recombinant human growth hormone administration |
| url | http://dx.doi.org/10.1155/2016/9648043 |
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