Association of changes in expression of HDAC and SIRT genes after drug treatment with cancer cell line sensitivity to kinase inhibitors

Association of changes in expression of HDAC and SIRT genes after drug treatment with cancer cell line sensitivity to kinase inhibitors

Histone deacetylases (HDACs) and sirtuins (SIRTs) are important epigenetic regulators of cancer pathways. There is a limited understanding of how transcriptional regulation of their genes is affected by chemotherapeutic agents, and how such transcriptional changes affect tumour sensitivity to drug t...

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Bibliographic Details
Main Authors: Julia Krushkal, Yingdong Zhao, Kyle Roney, Weimin Zhu, Alan Brooks, Deborah Wilsker, Ralph E. Parchment, Lisa M. McShane, James H. Doroshow
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Epigenetics
Subjects:
Histone deacetylase
sirtuin
dasatinib
chemosensitivity
HDAC5
Online Access:https://www.tandfonline.com/doi/10.1080/15592294.2024.2309824
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