Injectable and Conductive Polyurethane Gel with Load-Responsive Antibiosis for Sustained Root Canal Disinfection
To address the limitations of conventional antibacterial therapies, we developed an injectable, conductive polyurethane-based composite gel system for sustained root canal disinfection. This gel incorporates piezoelectric nanoparticles (n-BaTiO<sub>3</sub>) and conductive segments (anili...
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MDPI AG
2025-05-01
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| Online Access: | https://www.mdpi.com/2310-2861/11/5/346 |
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| author | Bo Mu Xiaoyu Lei Yinglong Zhang Jingzheng Zhang Qingda Du Yuping Li Dongyu Huang Li Wang Jidong Li Yubao Li Yi Zuo |
| author_facet | Bo Mu Xiaoyu Lei Yinglong Zhang Jingzheng Zhang Qingda Du Yuping Li Dongyu Huang Li Wang Jidong Li Yubao Li Yi Zuo |
| author_sort | Bo Mu |
| collection | DOAJ |
| description | To address the limitations of conventional antibacterial therapies, we developed an injectable, conductive polyurethane-based composite gel system for sustained root canal disinfection. This gel incorporates piezoelectric nanoparticles (n-BaTiO<sub>3</sub>) and conductive segments (aniline trimer, AT) within a polyurethane matrix, which synergistically interact with a static antimicrobial agent (n-ZnO) to achieve dynamic, mechano-responsive antibacterial activity. Under cyclic compression (simulating mastication), the piezoelectric gels exhibited enhanced electroactivity via the mechano-electric coupling effect, generating 2-fold higher voltage and a 1.8–1.9× increase in current compared to non-piezoelectric controls. The dynamic electroactivity of the gels enabled superior long-term performance, achieving 92–97% biofilm eradication, significantly higher than the static n-ZnO-only gel (88%). XPS and UV-vis spectroscopy analyses confirmed mechano-electrochemically amplified reactive oxygen species (ROS) generation, which contributed to improved biofilm disruption. The ISO-compliant gel provides durable, load-responsive disinfection while maintaining good biocompatibility, offering a promising solution to prevent post-treatment reinfection. |
| format | Article |
| id | doaj-art-76cc61d7469f4e8ba01edc3c4c89384c |
| institution | Kabale University |
| issn | 2310-2861 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj-art-76cc61d7469f4e8ba01edc3c4c89384c2025-08-20T03:47:54ZengMDPI AGGels2310-28612025-05-0111534610.3390/gels11050346Injectable and Conductive Polyurethane Gel with Load-Responsive Antibiosis for Sustained Root Canal DisinfectionBo Mu0Xiaoyu Lei1Yinglong Zhang2Jingzheng Zhang3Qingda Du4Yuping Li5Dongyu Huang6Li Wang7Jidong Li8Yubao Li9Yi Zuo10Research Center for Nano Biomaterials, Analytical & Testing Center, Sichuan University, Chengdu 610064, ChinaResearch Center for Nano Biomaterials, Analytical & Testing Center, Sichuan University, Chengdu 610064, ChinaResearch Center for Nano Biomaterials, Analytical & Testing Center, Sichuan University, Chengdu 610064, ChinaResearch Center for Nano Biomaterials, Analytical & Testing Center, Sichuan University, Chengdu 610064, ChinaResearch Center for Nano Biomaterials, Analytical & Testing Center, Sichuan University, Chengdu 610064, ChinaResearch Center for Nano Biomaterials, Analytical & Testing Center, Sichuan University, Chengdu 610064, ChinaResearch Center for Nano Biomaterials, Analytical & Testing Center, Sichuan University, Chengdu 610064, ChinaSchool of Big Health and Intelligent Engineering, Chengdu Medical College, Chengdu 610500, ChinaResearch Center for Nano Biomaterials, Analytical & Testing Center, Sichuan University, Chengdu 610064, ChinaResearch Center for Nano Biomaterials, Analytical & Testing Center, Sichuan University, Chengdu 610064, ChinaResearch Center for Nano Biomaterials, Analytical & Testing Center, Sichuan University, Chengdu 610064, ChinaTo address the limitations of conventional antibacterial therapies, we developed an injectable, conductive polyurethane-based composite gel system for sustained root canal disinfection. This gel incorporates piezoelectric nanoparticles (n-BaTiO<sub>3</sub>) and conductive segments (aniline trimer, AT) within a polyurethane matrix, which synergistically interact with a static antimicrobial agent (n-ZnO) to achieve dynamic, mechano-responsive antibacterial activity. Under cyclic compression (simulating mastication), the piezoelectric gels exhibited enhanced electroactivity via the mechano-electric coupling effect, generating 2-fold higher voltage and a 1.8–1.9× increase in current compared to non-piezoelectric controls. The dynamic electroactivity of the gels enabled superior long-term performance, achieving 92–97% biofilm eradication, significantly higher than the static n-ZnO-only gel (88%). XPS and UV-vis spectroscopy analyses confirmed mechano-electrochemically amplified reactive oxygen species (ROS) generation, which contributed to improved biofilm disruption. The ISO-compliant gel provides durable, load-responsive disinfection while maintaining good biocompatibility, offering a promising solution to prevent post-treatment reinfection.https://www.mdpi.com/2310-2861/11/5/346root canal therapypiezoelectric antibacterial gelmechano-electric couplingbiofilm eradicationsustained antibacterial |
| spellingShingle | Bo Mu Xiaoyu Lei Yinglong Zhang Jingzheng Zhang Qingda Du Yuping Li Dongyu Huang Li Wang Jidong Li Yubao Li Yi Zuo Injectable and Conductive Polyurethane Gel with Load-Responsive Antibiosis for Sustained Root Canal Disinfection Gels root canal therapy piezoelectric antibacterial gel mechano-electric coupling biofilm eradication sustained antibacterial |
| title | Injectable and Conductive Polyurethane Gel with Load-Responsive Antibiosis for Sustained Root Canal Disinfection |
| title_full | Injectable and Conductive Polyurethane Gel with Load-Responsive Antibiosis for Sustained Root Canal Disinfection |
| title_fullStr | Injectable and Conductive Polyurethane Gel with Load-Responsive Antibiosis for Sustained Root Canal Disinfection |
| title_full_unstemmed | Injectable and Conductive Polyurethane Gel with Load-Responsive Antibiosis for Sustained Root Canal Disinfection |
| title_short | Injectable and Conductive Polyurethane Gel with Load-Responsive Antibiosis for Sustained Root Canal Disinfection |
| title_sort | injectable and conductive polyurethane gel with load responsive antibiosis for sustained root canal disinfection |
| topic | root canal therapy piezoelectric antibacterial gel mechano-electric coupling biofilm eradication sustained antibacterial |
| url | https://www.mdpi.com/2310-2861/11/5/346 |
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