Effects of royal jelly consumption on inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials
Objective: This systematic review and meta-analysis examines the impact of royal jelly (RJ) on inflammation and oxidative stress. By synthesizing existing research, it aims to provide valuable insights into the potential health benefits of RJ.Materials and Methods: PubMed/Medline, Web of Science, an...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2025-07-01
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| Series: | Avicenna Journal of Phytomedicine |
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| Online Access: | https://ajp.mums.ac.ir/article_25139_f56c734d5601370d3ef121bfc6703765.pdf |
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| author | Shaghayegh Taheri Hossein Bahari Farshad Mirzavi Pegah Rahbarinejad Zohreh Sajadi Hezaveh Armin Doostparast Asghar Zarban Elyas Nattagh-Eshtivani |
| author_facet | Shaghayegh Taheri Hossein Bahari Farshad Mirzavi Pegah Rahbarinejad Zohreh Sajadi Hezaveh Armin Doostparast Asghar Zarban Elyas Nattagh-Eshtivani |
| author_sort | Shaghayegh Taheri |
| collection | DOAJ |
| description | Objective: This systematic review and meta-analysis examines the impact of royal jelly (RJ) on inflammation and oxidative stress. By synthesizing existing research, it aims to provide valuable insights into the potential health benefits of RJ.Materials and Methods: PubMed/Medline, Web of Science, and Scopus were searched until the end of December 2023. This meta-analysis included all randomized clinical trials assessing the effect of RJ supplements on serum levels of high-sensitivity C-reactive protein (hs-CRP), total antioxidant capacity (TAC), and malondialdehyde (MDA). A random-effects model was utilized to calculate the pooled mean differences (MD) and 95% confidence interval.Results: Seven suitable datasets from 6 trials were considered eligible. RJ supplementation significantly reduced MDA (WMD, –1.79 (–3.00 to –0.58), p=0.004; I2 = 97.4%) and increased TAC (WMD, 0.98 (0.24 to 1.71), p=0.009, I2 = 98.5%), but it did not significantly change hs-CRP levels (WMD: -0.24; 95% CI: -0.60, 0.10; p=0.17). RJ supplementation in higher doses and in participants with normal body mass index (BMI) could induce a greater elevation in TAC, and in participants with normal BMI, a stronger reduction in MDA.Conclusion: Although this meta-analysis confirmed that RJ could be a useful intervention to reduce oxidative stress, this research should be updated in future due to the restricted number of trials. |
| format | Article |
| id | doaj-art-76cb1e881564407ba5d8a36b6e89fdd6 |
| institution | DOAJ |
| issn | 2228-7930 2228-7949 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Avicenna Journal of Phytomedicine |
| spelling | doaj-art-76cb1e881564407ba5d8a36b6e89fdd62025-08-20T02:48:05ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492025-07-011541264127810.22038/ajp.2024.2513925139Effects of royal jelly consumption on inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trialsShaghayegh Taheri0Hossein Bahari1Farshad Mirzavi2Pegah Rahbarinejad3Zohreh Sajadi Hezaveh4Armin Doostparast5Asghar Zarban6Elyas Nattagh-Eshtivani7Department of Clinical Biochemistry, School of Medicine, Birjand University of Medical Sciences, Birjand, IranTransplant Research Center, Clinical Research Institute, Mashhad University of Medical Sciences, Mashhad, IranCardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, IranDepartment of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranFaculty of Medicine and Health, Department of Health Sciences, The University of Sydney, Sydney, NSW, AustraliaTransplant Research Center, Clinical Research Institute, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Clinical Biochemistry, School of Medicine, Birjand University of Medical Sciences, Birjand, IranDepartment of Nutrition, Food Sciences and Clinical Biochemistry, School of Medicine, Social Determinants of Health Research Center, Gonabad University of Medical Science, Gonabad, IranObjective: This systematic review and meta-analysis examines the impact of royal jelly (RJ) on inflammation and oxidative stress. By synthesizing existing research, it aims to provide valuable insights into the potential health benefits of RJ.Materials and Methods: PubMed/Medline, Web of Science, and Scopus were searched until the end of December 2023. This meta-analysis included all randomized clinical trials assessing the effect of RJ supplements on serum levels of high-sensitivity C-reactive protein (hs-CRP), total antioxidant capacity (TAC), and malondialdehyde (MDA). A random-effects model was utilized to calculate the pooled mean differences (MD) and 95% confidence interval.Results: Seven suitable datasets from 6 trials were considered eligible. RJ supplementation significantly reduced MDA (WMD, –1.79 (–3.00 to –0.58), p=0.004; I2 = 97.4%) and increased TAC (WMD, 0.98 (0.24 to 1.71), p=0.009, I2 = 98.5%), but it did not significantly change hs-CRP levels (WMD: -0.24; 95% CI: -0.60, 0.10; p=0.17). RJ supplementation in higher doses and in participants with normal body mass index (BMI) could induce a greater elevation in TAC, and in participants with normal BMI, a stronger reduction in MDA.Conclusion: Although this meta-analysis confirmed that RJ could be a useful intervention to reduce oxidative stress, this research should be updated in future due to the restricted number of trials.https://ajp.mums.ac.ir/article_25139_f56c734d5601370d3ef121bfc6703765.pdfmalondialdehydeantioxidantroyal jellyoxidation-reductionc-reactive proteinmeta-analysis |
| spellingShingle | Shaghayegh Taheri Hossein Bahari Farshad Mirzavi Pegah Rahbarinejad Zohreh Sajadi Hezaveh Armin Doostparast Asghar Zarban Elyas Nattagh-Eshtivani Effects of royal jelly consumption on inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials Avicenna Journal of Phytomedicine malondialdehyde antioxidant royal jelly oxidation-reduction c-reactive protein meta-analysis |
| title | Effects of royal jelly consumption on inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials |
| title_full | Effects of royal jelly consumption on inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials |
| title_fullStr | Effects of royal jelly consumption on inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials |
| title_full_unstemmed | Effects of royal jelly consumption on inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials |
| title_short | Effects of royal jelly consumption on inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials |
| title_sort | effects of royal jelly consumption on inflammation and oxidative stress a systematic review and meta analysis of randomized controlled trials |
| topic | malondialdehyde antioxidant royal jelly oxidation-reduction c-reactive protein meta-analysis |
| url | https://ajp.mums.ac.ir/article_25139_f56c734d5601370d3ef121bfc6703765.pdf |
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