Glucose-6-phosphate dehydrogenase status and severity of malarial anaemia in Nigerian children
Introduction: Glucose-6-phosphate dehydrogenase (G6PD) deficiency (Gd-) contributes to morbidity and mortality in sub-Saharan Africa but recent data on the interaction between Gd- and malaria among children is scarce. We hypothesised that, being a haemolytic factor, Gd- makes severe malarial anaemi...
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The Journal of Infection in Developing Countries
2011-11-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/1837 |
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| author | Adebola Emmanuel Orimadegun Olugbemiro Sodeinde |
| author_facet | Adebola Emmanuel Orimadegun Olugbemiro Sodeinde |
| author_sort | Adebola Emmanuel Orimadegun |
| collection | DOAJ |
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Introduction: Glucose-6-phosphate dehydrogenase (G6PD) deficiency (Gd-) contributes to morbidity and mortality in sub-Saharan Africa but recent data on the interaction between Gd- and malaria among children is scarce. We hypothesised that, being a haemolytic factor, Gd- makes severe malarial anaemia (SMA) more common and even more severe.
Methodology: We selected 930 children aged 0.5-12 years attending a reference hospital with microscopically proven falciparum malaria. G6PD and haemoglobin were typed by the fluorescent spot test and electrophoresis, respectively. Molecular typing by PCR and restriction enzyme digestion was also performed on 15% of randomly selected samples. Haematocrit (PCV) values, haemoglobin type, blood group, presence of sickle cell trait (HbAS), and parasite counts were compared between G6PD-normal and deficient children.
Results: Prevalence of Gd- was 16.4% and 8.1% among boys and girls with malaria, respectively. Mean PCV was 22.8% in deficient children compared with 21.0% in normal children (p=0.041). In boys, 2.7% of Gd- had PCV ≤10%, as compared to 13.6% in Gd+ (p = 0.005). Similarly, 21.3% of Gd- had PCV ≤15% compared with 39.4% in Gd+ (p=0.003). No such difference was found among girls. Overall, HbAS was typed in 7.6% and was more common in Gd- (13.0%) than in Gd+ (6.8%), but the difference was not statistically significant (p=0.058). The mean parasite counts were significantly lower in Gd- (15477.5/μl) than in Gd+ (19784.4/μl; p=0.013), and it was independent from HbAS.
Conclusion: Gd- males but not females were significantly less likely to develop severe malarial anaemia.
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| format | Article |
| id | doaj-art-76c97b25183d4b95ab3bd090511c95a6 |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2011-11-01 |
| publisher | The Journal of Infection in Developing Countries |
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| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-76c97b25183d4b95ab3bd090511c95a62025-08-20T02:27:20ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802011-11-0151110.3855/jidc.1837Glucose-6-phosphate dehydrogenase status and severity of malarial anaemia in Nigerian childrenAdebola Emmanuel Orimadegun0Olugbemiro Sodeinde1Institute of Child Health, College of Medicine, University of Ibadan, Ibadan NigeriaUniversity College Hospital, Ibadan, Nigeria Introduction: Glucose-6-phosphate dehydrogenase (G6PD) deficiency (Gd-) contributes to morbidity and mortality in sub-Saharan Africa but recent data on the interaction between Gd- and malaria among children is scarce. We hypothesised that, being a haemolytic factor, Gd- makes severe malarial anaemia (SMA) more common and even more severe. Methodology: We selected 930 children aged 0.5-12 years attending a reference hospital with microscopically proven falciparum malaria. G6PD and haemoglobin were typed by the fluorescent spot test and electrophoresis, respectively. Molecular typing by PCR and restriction enzyme digestion was also performed on 15% of randomly selected samples. Haematocrit (PCV) values, haemoglobin type, blood group, presence of sickle cell trait (HbAS), and parasite counts were compared between G6PD-normal and deficient children. Results: Prevalence of Gd- was 16.4% and 8.1% among boys and girls with malaria, respectively. Mean PCV was 22.8% in deficient children compared with 21.0% in normal children (p=0.041). In boys, 2.7% of Gd- had PCV ≤10%, as compared to 13.6% in Gd+ (p = 0.005). Similarly, 21.3% of Gd- had PCV ≤15% compared with 39.4% in Gd+ (p=0.003). No such difference was found among girls. Overall, HbAS was typed in 7.6% and was more common in Gd- (13.0%) than in Gd+ (6.8%), but the difference was not statistically significant (p=0.058). The mean parasite counts were significantly lower in Gd- (15477.5/μl) than in Gd+ (19784.4/μl; p=0.013), and it was independent from HbAS. Conclusion: Gd- males but not females were significantly less likely to develop severe malarial anaemia. https://jidc.org/index.php/journal/article/view/1837glucose-6-phosphate dehydrogenase deficiencymalarial anaemiahaemolytic anaemia |
| spellingShingle | Adebola Emmanuel Orimadegun Olugbemiro Sodeinde Glucose-6-phosphate dehydrogenase status and severity of malarial anaemia in Nigerian children Journal of Infection in Developing Countries glucose-6-phosphate dehydrogenase deficiency malarial anaemia haemolytic anaemia |
| title | Glucose-6-phosphate dehydrogenase status and severity of malarial anaemia in Nigerian children |
| title_full | Glucose-6-phosphate dehydrogenase status and severity of malarial anaemia in Nigerian children |
| title_fullStr | Glucose-6-phosphate dehydrogenase status and severity of malarial anaemia in Nigerian children |
| title_full_unstemmed | Glucose-6-phosphate dehydrogenase status and severity of malarial anaemia in Nigerian children |
| title_short | Glucose-6-phosphate dehydrogenase status and severity of malarial anaemia in Nigerian children |
| title_sort | glucose 6 phosphate dehydrogenase status and severity of malarial anaemia in nigerian children |
| topic | glucose-6-phosphate dehydrogenase deficiency malarial anaemia haemolytic anaemia |
| url | https://jidc.org/index.php/journal/article/view/1837 |
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