Postradiation platinum–etoposide in adult medulloblastomas: retrospective analysis of hematological toxicity
Aim: Adult medulloblastomas (MB) are rare, and optimal post-craniospinal irradiation (CSI) chemotherapy is not yet defined. We investigated hematological toxicity in patients treated with platinum–etoposide (EP) post-CSI. Methods: Retrospective, single-institution study to determine hematological to...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | CNS Oncology |
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| Online Access: | https://www.tandfonline.com/doi/10.2217/cns-2023-0029 |
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| author | Edina Komlodi-Pasztor Vasu Munjapara Charles G Eberhart Danielle A Bazer Mohamed R Sherief David Olayinka Kamson Xiaobu Ye Byram Hirsch Ozer Matthias Holdhoff |
| author_facet | Edina Komlodi-Pasztor Vasu Munjapara Charles G Eberhart Danielle A Bazer Mohamed R Sherief David Olayinka Kamson Xiaobu Ye Byram Hirsch Ozer Matthias Holdhoff |
| author_sort | Edina Komlodi-Pasztor |
| collection | DOAJ |
| description | Aim: Adult medulloblastomas (MB) are rare, and optimal post-craniospinal irradiation (CSI) chemotherapy is not yet defined. We investigated hematological toxicity in patients treated with platinum–etoposide (EP) post-CSI. Methods: Retrospective, single-institution study to determine hematological toxicity in adult MB patients treated with EP (1995–2022). Results: Thirteen patients with a median follow-up of 50 months (range, 10–233) were analyzed. Four discontinued treatment due to toxicity, one after 1, 3 after 3 cycles. Hematological toxicities included grade 3 (5 patients) and grade 4 (6 patients). Two patients experienced post-treatment progression and died 16 and 37 months from diagnosis. Conclusion: Post-CSI EP demonstrates acceptable hematological toxicity in adult MB. However, the small cohort precludes definitive survival outcome conclusions. Prospective studies for comprehensive comparisons with other regimens are needed in this context. |
| format | Article |
| id | doaj-art-76c3189c2ee34db18a92af5c3fd23517 |
| institution | OA Journals |
| issn | 2045-0907 2045-0915 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | CNS Oncology |
| spelling | doaj-art-76c3189c2ee34db18a92af5c3fd235172025-08-20T02:07:09ZengTaylor & Francis GroupCNS Oncology2045-09072045-09152024-12-0113110.2217/cns-2023-0029Postradiation platinum–etoposide in adult medulloblastomas: retrospective analysis of hematological toxicityEdina Komlodi-Pasztor0Vasu Munjapara1Charles G Eberhart2Danielle A Bazer3Mohamed R Sherief4David Olayinka Kamson5Xiaobu Ye6Byram Hirsch Ozer7Matthias Holdhoff8Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, 201 N Broadway, Baltimore, MD 21287, USADepartment of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, 201 N Broadway, Baltimore, MD 21287, USADepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USADepartment of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, 201 N Broadway, Baltimore, MD 21287, USADepartment of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, 201 N Broadway, Baltimore, MD 21287, USADepartment of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, 201 N Broadway, Baltimore, MD 21287, USADepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USADepartment of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, 201 N Broadway, Baltimore, MD 21287, USADepartment of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, 201 N Broadway, Baltimore, MD 21287, USAAim: Adult medulloblastomas (MB) are rare, and optimal post-craniospinal irradiation (CSI) chemotherapy is not yet defined. We investigated hematological toxicity in patients treated with platinum–etoposide (EP) post-CSI. Methods: Retrospective, single-institution study to determine hematological toxicity in adult MB patients treated with EP (1995–2022). Results: Thirteen patients with a median follow-up of 50 months (range, 10–233) were analyzed. Four discontinued treatment due to toxicity, one after 1, 3 after 3 cycles. Hematological toxicities included grade 3 (5 patients) and grade 4 (6 patients). Two patients experienced post-treatment progression and died 16 and 37 months from diagnosis. Conclusion: Post-CSI EP demonstrates acceptable hematological toxicity in adult MB. However, the small cohort precludes definitive survival outcome conclusions. Prospective studies for comprehensive comparisons with other regimens are needed in this context.https://www.tandfonline.com/doi/10.2217/cns-2023-0029adult medulloblastomacisplatincraniospinal radiationetoposidemedulloblastoma |
| spellingShingle | Edina Komlodi-Pasztor Vasu Munjapara Charles G Eberhart Danielle A Bazer Mohamed R Sherief David Olayinka Kamson Xiaobu Ye Byram Hirsch Ozer Matthias Holdhoff Postradiation platinum–etoposide in adult medulloblastomas: retrospective analysis of hematological toxicity CNS Oncology adult medulloblastoma cisplatin craniospinal radiation etoposide medulloblastoma |
| title | Postradiation platinum–etoposide in adult medulloblastomas: retrospective analysis of hematological toxicity |
| title_full | Postradiation platinum–etoposide in adult medulloblastomas: retrospective analysis of hematological toxicity |
| title_fullStr | Postradiation platinum–etoposide in adult medulloblastomas: retrospective analysis of hematological toxicity |
| title_full_unstemmed | Postradiation platinum–etoposide in adult medulloblastomas: retrospective analysis of hematological toxicity |
| title_short | Postradiation platinum–etoposide in adult medulloblastomas: retrospective analysis of hematological toxicity |
| title_sort | postradiation platinum etoposide in adult medulloblastomas retrospective analysis of hematological toxicity |
| topic | adult medulloblastoma cisplatin craniospinal radiation etoposide medulloblastoma |
| url | https://www.tandfonline.com/doi/10.2217/cns-2023-0029 |
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