Lack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development

Lack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development

Regulatory T (Treg) cells are essential for the maintenance of immunological tolerance, yet the molecular components required for their maintenance and effector functions remain incompletely defined. Inactivation of VPS34 in Treg cells led to an early, lethal phenotype, with massive effector T cell...

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Bibliographic Details
Main Authors: Christina J. F. Courreges, Elizabeth C. M. Davenport, Benoit Bilanges, Elena Rebollo-Gomez, Jens Hukelmann, Priya Schoenfelder, James R. Edgar, David Sansom, Cheryl L. Scudamore, Rahul Roychoudhuri, Oliver A. Garden, Bart Vanhaesebroeck, Klaus Okkenhaug
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
PI3K
Treg
VPS34
autophagy
endocytosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1374621/full
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