Short Term Comparison Between Safety and Efficacy of Rosuvastatin 40 mg and Atorvastatin 80 mg in Patients with Acute Coronary Syndrome
Background. Dyslipidemia is one of the most serious modifiable risk factors for acute coronary syndrome which is the most leading cause of mortality and morbidity worldwide.Aim. To assess the short-term safety and efficacy of full dose rosuvastatin and atorvastatin in patients with acute coronary ...
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Столичная издательская компания
2018-11-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/1743 |
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| author | Sh. A. Mostafa Kh. Elrabat M. Mahrous M. Kamal |
| author_facet | Sh. A. Mostafa Kh. Elrabat M. Mahrous M. Kamal |
| author_sort | Sh. A. Mostafa |
| collection | DOAJ |
| description | Background. Dyslipidemia is one of the most serious modifiable risk factors for acute coronary syndrome which is the most leading cause of mortality and morbidity worldwide.Aim. To assess the short-term safety and efficacy of full dose rosuvastatin and atorvastatin in patients with acute coronary syndrome.Material and methods. Single center, prospective, randomized study included 100 patients who were randomized from first 24-hour of admission to either atorvastatin 80 mg daily (group 1) or rosuvastatin 40 mg daily (group 2). Primary outcomes included levels of inflammatory markers (erythrocyte sedimentation rate [ESR], high-sensitive C-reactive protein [hs-CRP] and total leukocyte count [TLC]) after 4 weeks of treatment and lipid profile after 3 months. Secondary outcomes included recurrent myocardial infarction, recurrent angina, stroke and side effects.Results. At admission, both groups were comparable in age, without statistically significant difference regarding risk factors (diabetes, hypertension, smoking and obesity), echocardiography (end-diastolic volume, end-systolic volume and ejection fraction), laboratory parameters of inflammation and lipid profile. After 1 month, there was insignificant difference between rosuvastatin and atorvastatin in the reduction of ESR, Hs-CRP or TLC. After 3 months rosuvastatin showed statistically significant reduction in the level of low-density lipoprotein cholesterol, triglyceride (p<0.001) and significant increase in high-density lipoprotein cholesterol (p<0.001) when compared to atorvastatin and at the same time the rosuvastatin group was safer regarding liver enzymes elevation, p<0.001 for alanine and p<0.01 for aspartate aminotransferases, respectively.Conclusions. Our findings demonstrated that rosuvastatin 40 mg/day is safer and more effective than the atorvastatin 80 mg/day in the terms of lipid parameters and inflammatory biomarkers. |
| format | Article |
| id | doaj-art-76bcf8457cc34772b28b3fc6eb068585 |
| institution | Kabale University |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2018-11-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-76bcf8457cc34772b28b3fc6eb0685852025-08-23T10:00:30ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532018-11-0114563664510.20996/1819-6446-2018-14-5-636-6451517Short Term Comparison Between Safety and Efficacy of Rosuvastatin 40 mg and Atorvastatin 80 mg in Patients with Acute Coronary SyndromeSh. A. Mostafa0Kh. Elrabat1M. Mahrous2M. Kamal3Benha University, Faculty of Medicine, Cardiovascular DepartmentBenha University, Faculty of Medicine, Cardiovascular DepartmentBenha University, Faculty of Medicine, Cardiovascular DepartmentBenha University, Faculty of Medicine, Cardiovascular DepartmentBackground. Dyslipidemia is one of the most serious modifiable risk factors for acute coronary syndrome which is the most leading cause of mortality and morbidity worldwide.Aim. To assess the short-term safety and efficacy of full dose rosuvastatin and atorvastatin in patients with acute coronary syndrome.Material and methods. Single center, prospective, randomized study included 100 patients who were randomized from first 24-hour of admission to either atorvastatin 80 mg daily (group 1) or rosuvastatin 40 mg daily (group 2). Primary outcomes included levels of inflammatory markers (erythrocyte sedimentation rate [ESR], high-sensitive C-reactive protein [hs-CRP] and total leukocyte count [TLC]) after 4 weeks of treatment and lipid profile after 3 months. Secondary outcomes included recurrent myocardial infarction, recurrent angina, stroke and side effects.Results. At admission, both groups were comparable in age, without statistically significant difference regarding risk factors (diabetes, hypertension, smoking and obesity), echocardiography (end-diastolic volume, end-systolic volume and ejection fraction), laboratory parameters of inflammation and lipid profile. After 1 month, there was insignificant difference between rosuvastatin and atorvastatin in the reduction of ESR, Hs-CRP or TLC. After 3 months rosuvastatin showed statistically significant reduction in the level of low-density lipoprotein cholesterol, triglyceride (p<0.001) and significant increase in high-density lipoprotein cholesterol (p<0.001) when compared to atorvastatin and at the same time the rosuvastatin group was safer regarding liver enzymes elevation, p<0.001 for alanine and p<0.01 for aspartate aminotransferases, respectively.Conclusions. Our findings demonstrated that rosuvastatin 40 mg/day is safer and more effective than the atorvastatin 80 mg/day in the terms of lipid parameters and inflammatory biomarkers.https://www.rpcardio.online/jour/article/view/1743atorvastatinrosuvastatinacute coronary syndromestatins |
| spellingShingle | Sh. A. Mostafa Kh. Elrabat M. Mahrous M. Kamal Short Term Comparison Between Safety and Efficacy of Rosuvastatin 40 mg and Atorvastatin 80 mg in Patients with Acute Coronary Syndrome Рациональная фармакотерапия в кардиологии atorvastatin rosuvastatin acute coronary syndrome statins |
| title | Short Term Comparison Between Safety and Efficacy of Rosuvastatin 40 mg and Atorvastatin 80 mg in Patients with Acute Coronary Syndrome |
| title_full | Short Term Comparison Between Safety and Efficacy of Rosuvastatin 40 mg and Atorvastatin 80 mg in Patients with Acute Coronary Syndrome |
| title_fullStr | Short Term Comparison Between Safety and Efficacy of Rosuvastatin 40 mg and Atorvastatin 80 mg in Patients with Acute Coronary Syndrome |
| title_full_unstemmed | Short Term Comparison Between Safety and Efficacy of Rosuvastatin 40 mg and Atorvastatin 80 mg in Patients with Acute Coronary Syndrome |
| title_short | Short Term Comparison Between Safety and Efficacy of Rosuvastatin 40 mg and Atorvastatin 80 mg in Patients with Acute Coronary Syndrome |
| title_sort | short term comparison between safety and efficacy of rosuvastatin 40 mg and atorvastatin 80 mg in patients with acute coronary syndrome |
| topic | atorvastatin rosuvastatin acute coronary syndrome statins |
| url | https://www.rpcardio.online/jour/article/view/1743 |
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