Identifying heterogeneity of treatment effect for antibiotic duration in bloodstream infection: an exploratory post-hoc analysis of the BALANCE randomised clinical trialResearch in context

Identifying heterogeneity of treatment effect for antibiotic duration in bloodstream infection: an exploratory post-hoc analysis of the BALANCE randomised clinical trialResearch in context

Summary: Background: The BALANCE trial demonstrated non-inferiority of 7 (vs 14) day antibiotic durations in patients with uncomplicated non-S. aureus/lugdunensis bacterial bloodstream infections (BSI). However, there may be patient subgroups who benefit from longer durations. We aimed to evaluate...

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Main Authors: Sean W.X. Ong, Ruxandra Pinto, Asgar Rishu, Steven Y.C. Tong, Robert J. Commons, John M. Conly, Gerald A. Evans, Michael Fralick, Christopher Kandel, Philippe R.S. Lagacé-Wiens, Todd C. Lee, Sylvain A. Lother, Derek R. MacFadden, John C. Marshall, Valérie Martel-Laferrière, Michael Mayette, Emily G. McDonald, John D. Neary, Josef Prazak, Edward Raby, Adrian Regli, Benjamin A. Rogers, Stephanie Smith, Linda R. Taggart, Han Ting Wang, Terence Wuerz, Dafna Yahav, Paul J. Young, Robert A. Fowler, Nick Daneman, Benjamin Rogers, Yahya Shehabi, Rachael Parke, Deborah J. Cook, Yaseen Arabi, John Muscedere, Steven Reynolds, Richard Hall, Dhiraj Bhatia Dwivedi, Colin McArthur, Shay McGuinness, Bryan Coburn, Anna Geagea, Pavani Das, Phillip Shin, Michael Detsky, Andrew Morris, Jeff E. Powis, Wendy Sligl, Sean M. Bagshaw, Nishma Singhal, Emilie Belley-Cote, Richard Whitlock, Kosar Khwaja, Susan Morpeth, Alex Kazemi, Tony Williams, Lauralyn McIntyre, Jennifer L.Y. Tsang, Francois Lamontagne, Alex Carignan, John Marshall, Jan O. Friedrich, Robert Cirone, Mark Downing, Christopher Graham, Joshua Davis, Erick Duan, John Neary, Gerald Evans, Basem Alraddadi, Sameera Al Johani, Claudio Martin, Sameer Elsayed, Ian Ball, François Lauzier, Alexis F. Turgeon, Henry Thomas Stelfox, John Conly, Richard Sullivan, Jennifer Grant, Ilya Kagan, Paul Young, Cassie Lawrence, Kevin O'Callaghan, Matthew Eustace, Keat Choong, Pierre Aslanian, Ulrike Buehner, Tom Havey, Alexandra Binnie, Brenda Reeve, Edward Litton, Sylvain Lother, Anand Kumar, Ryan Zarychanski, Tomer Hoffman, David L. Paterson, Peter Daley, Emmanuel Charbonney, Jean-Francois Naud, Sally Roberts, Ravindranath Tiruvoipati, Sachin Gupta, Gordon Wood, Omar Shum, Spiros Miyakis, Peter Dodek, Clement Kwok, Karen Doucette
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:EClinicalMedicine
Subjects:
Bloodstream infections
Antibiotic duration
Clinical trial
Heterogeneity of treatment effect
Antimicrobial stewardship
Online Access:http://www.sciencedirect.com/science/article/pii/S2589537025001270
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