Cenosphere-Based 177Lu-Aluminosilicate Microspheres as a Theranostic β-Emitter for Selective Internal Radiation Therapy of Hepatic Tumors
The narrow fraction of the cenospheres of coal fly ash (30−50 μm; glass phase ∼ 90 wt. %) was used for the preparation of β-emitting 177Lu-bearing aluminosilicate microspheres. Two methods of chemical modification to encapsulate 177Lu3+ in the cenosphere’s aluminosilicate matrix were used, such as t...
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| Format: | Article |
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Wiley
2024-01-01
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| Series: | Science and Technology of Nuclear Installations |
| Online Access: | http://dx.doi.org/10.1155/2024/1266658 |
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| author | Tatiana A. Vereshchagina Ekaterina A. Kutikhina Ivan A. Ushakov Valery V. Zukau Evgeniy A. Nesterov Alexander G. Anshits |
| author_facet | Tatiana A. Vereshchagina Ekaterina A. Kutikhina Ivan A. Ushakov Valery V. Zukau Evgeniy A. Nesterov Alexander G. Anshits |
| author_sort | Tatiana A. Vereshchagina |
| collection | DOAJ |
| description | The narrow fraction of the cenospheres of coal fly ash (30−50 μm; glass phase ∼ 90 wt. %) was used for the preparation of β-emitting 177Lu-bearing aluminosilicate microspheres. Two methods of chemical modification to encapsulate 177Lu3+ in the cenosphere’s aluminosilicate matrix were used, such as the formation of (i) microporous or (ii) meso/macroporous structure in the cenosphere shell followed by 175+176Lu3+ sorption. Conversion of Lu-loaded microspheres into poorly soluble forms was performed via the thermal treatment at 900–1200°C and then 176Lu was transformed to 177Lu by neutron activation procedure in a nuclear reactor. The 176Lu-bearing products were studied by PXRD, SEM, and EDX spectroscopy methods. It was established that the acid treatment of cenospheres resulting in a meso/macroporous structure in the cenosphere shell is the optimal nondestructive method to produce a microsphere precursor for Lu incorporation. The neutron activation of 176Lu-bearing microspheres resulted in 177Lu-microspheres that provide the specific radioactivity of 4.5 GBq/100 mg. The Lu leaching rate from 177Lu-microspheres in a blood simulator determined according to the State Standard (GOST) R 52126-2003 was about 10−6−10−7 g/cm2⋅day. |
| format | Article |
| id | doaj-art-76b96f6487264aecb81b7801bfe7bf57 |
| institution | OA Journals |
| issn | 1687-6083 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
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| series | Science and Technology of Nuclear Installations |
| spelling | doaj-art-76b96f6487264aecb81b7801bfe7bf572025-08-20T02:07:34ZengWileyScience and Technology of Nuclear Installations1687-60832024-01-01202410.1155/2024/1266658Cenosphere-Based 177Lu-Aluminosilicate Microspheres as a Theranostic β-Emitter for Selective Internal Radiation Therapy of Hepatic TumorsTatiana A. Vereshchagina0Ekaterina A. Kutikhina1Ivan A. Ushakov2Valery V. Zukau3Evgeniy A. Nesterov4Alexander G. Anshits5Institute of Chemistry and Chemical TechnologyInstitute of Chemistry and Chemical TechnologyDepartment of Research Nuclear ReactorDepartment of Research Nuclear ReactorDepartment of Research Nuclear ReactorInstitute of Chemistry and Chemical TechnologyThe narrow fraction of the cenospheres of coal fly ash (30−50 μm; glass phase ∼ 90 wt. %) was used for the preparation of β-emitting 177Lu-bearing aluminosilicate microspheres. Two methods of chemical modification to encapsulate 177Lu3+ in the cenosphere’s aluminosilicate matrix were used, such as the formation of (i) microporous or (ii) meso/macroporous structure in the cenosphere shell followed by 175+176Lu3+ sorption. Conversion of Lu-loaded microspheres into poorly soluble forms was performed via the thermal treatment at 900–1200°C and then 176Lu was transformed to 177Lu by neutron activation procedure in a nuclear reactor. The 176Lu-bearing products were studied by PXRD, SEM, and EDX spectroscopy methods. It was established that the acid treatment of cenospheres resulting in a meso/macroporous structure in the cenosphere shell is the optimal nondestructive method to produce a microsphere precursor for Lu incorporation. The neutron activation of 176Lu-bearing microspheres resulted in 177Lu-microspheres that provide the specific radioactivity of 4.5 GBq/100 mg. The Lu leaching rate from 177Lu-microspheres in a blood simulator determined according to the State Standard (GOST) R 52126-2003 was about 10−6−10−7 g/cm2⋅day.http://dx.doi.org/10.1155/2024/1266658 |
| spellingShingle | Tatiana A. Vereshchagina Ekaterina A. Kutikhina Ivan A. Ushakov Valery V. Zukau Evgeniy A. Nesterov Alexander G. Anshits Cenosphere-Based 177Lu-Aluminosilicate Microspheres as a Theranostic β-Emitter for Selective Internal Radiation Therapy of Hepatic Tumors Science and Technology of Nuclear Installations |
| title | Cenosphere-Based 177Lu-Aluminosilicate Microspheres as a Theranostic β-Emitter for Selective Internal Radiation Therapy of Hepatic Tumors |
| title_full | Cenosphere-Based 177Lu-Aluminosilicate Microspheres as a Theranostic β-Emitter for Selective Internal Radiation Therapy of Hepatic Tumors |
| title_fullStr | Cenosphere-Based 177Lu-Aluminosilicate Microspheres as a Theranostic β-Emitter for Selective Internal Radiation Therapy of Hepatic Tumors |
| title_full_unstemmed | Cenosphere-Based 177Lu-Aluminosilicate Microspheres as a Theranostic β-Emitter for Selective Internal Radiation Therapy of Hepatic Tumors |
| title_short | Cenosphere-Based 177Lu-Aluminosilicate Microspheres as a Theranostic β-Emitter for Selective Internal Radiation Therapy of Hepatic Tumors |
| title_sort | cenosphere based 177lu aluminosilicate microspheres as a theranostic β emitter for selective internal radiation therapy of hepatic tumors |
| url | http://dx.doi.org/10.1155/2024/1266658 |
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