Nutrigenomic regulation of sensory plasticity
Diet profoundly influences brain physiology, but how metabolic information is transmuted into neural activity and behavior changes remains elusive. Here, we show that the metabolic enzyme O-GlcNAc Transferase (OGT) moonlights on the chromatin of the D. melanogaster gustatory neurons to instruct chan...
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2023-03-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/83979 |
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| _version_ | 1832587294030168064 |
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| author | Hayeon Sung Anoumid Vaziri Daniel Wilinski Riley KR Woerner Lydia Freddolino Monica Dus |
| author_facet | Hayeon Sung Anoumid Vaziri Daniel Wilinski Riley KR Woerner Lydia Freddolino Monica Dus |
| author_sort | Hayeon Sung |
| collection | DOAJ |
| description | Diet profoundly influences brain physiology, but how metabolic information is transmuted into neural activity and behavior changes remains elusive. Here, we show that the metabolic enzyme O-GlcNAc Transferase (OGT) moonlights on the chromatin of the D. melanogaster gustatory neurons to instruct changes in chromatin accessibility and transcription that underlie sensory adaptations to a high-sugar diet. OGT works synergistically with the Mitogen Activated Kinase/Extracellular signal Regulated Kinase (MAPK/ERK) rolled and its effector stripe (also known as EGR2 or Krox20) to integrate activity information. OGT also cooperates with the epigenetic silencer Polycomb Repressive Complex 2.1 (PRC2.1) to decrease chromatin accessibility and repress transcription in the high-sugar diet. This integration of nutritional and activity information changes the taste neurons’ responses to sugar and the flies’ ability to sense sweetness. Our findings reveal how nutrigenomic signaling generates neural activity and behavior in response to dietary changes in the sensory neurons. |
| format | Article |
| id | doaj-art-76b83b9ae22541ebb6a83c7482031a66 |
| institution | Kabale University |
| issn | 2050-084X |
| language | English |
| publishDate | 2023-03-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj-art-76b83b9ae22541ebb6a83c7482031a662025-01-24T14:07:07ZengeLife Sciences Publications LtdeLife2050-084X2023-03-011210.7554/eLife.83979Nutrigenomic regulation of sensory plasticityHayeon Sung0https://orcid.org/0000-0002-9015-8877Anoumid Vaziri1Daniel Wilinski2Riley KR Woerner3https://orcid.org/0009-0000-0702-138XLydia Freddolino4https://orcid.org/0000-0002-5821-4226Monica Dus5https://orcid.org/0000-0003-1465-9028Department of Molecular, Cellular and Developmental Biology, College of Literature, Science, and the Arts, The University of Michigan, Ann Arbor, United StatesDepartment of Molecular, Cellular and Developmental Biology, College of Literature, Science, and the Arts, The University of Michigan, Ann Arbor, United States; The Molecular, Cellular and Developmental Biology Graduate Program, The University of Michigan, Ann Arbor, United StatesDepartment of Molecular, Cellular and Developmental Biology, College of Literature, Science, and the Arts, The University of Michigan, Ann Arbor, United StatesDepartment of Molecular, Cellular and Developmental Biology, College of Literature, Science, and the Arts, The University of Michigan, Ann Arbor, United StatesDepartment of Biological Chemistry, The University of Michigan Medical School, Ann Arbor, United States; Department of Computational Medicine and Bioinformatics, The University of Michigan Medical School, Ann Arbor, United StatesDepartment of Molecular, Cellular and Developmental Biology, College of Literature, Science, and the Arts, The University of Michigan, Ann Arbor, United States; The Molecular, Cellular and Developmental Biology Graduate Program, The University of Michigan, Ann Arbor, United States; The Michigan Neuroscience Institute, Ann Arbor, United StatesDiet profoundly influences brain physiology, but how metabolic information is transmuted into neural activity and behavior changes remains elusive. Here, we show that the metabolic enzyme O-GlcNAc Transferase (OGT) moonlights on the chromatin of the D. melanogaster gustatory neurons to instruct changes in chromatin accessibility and transcription that underlie sensory adaptations to a high-sugar diet. OGT works synergistically with the Mitogen Activated Kinase/Extracellular signal Regulated Kinase (MAPK/ERK) rolled and its effector stripe (also known as EGR2 or Krox20) to integrate activity information. OGT also cooperates with the epigenetic silencer Polycomb Repressive Complex 2.1 (PRC2.1) to decrease chromatin accessibility and repress transcription in the high-sugar diet. This integration of nutritional and activity information changes the taste neurons’ responses to sugar and the flies’ ability to sense sweetness. Our findings reveal how nutrigenomic signaling generates neural activity and behavior in response to dietary changes in the sensory neurons.https://elifesciences.org/articles/83979sensory neurosciencegene regulationnutrition |
| spellingShingle | Hayeon Sung Anoumid Vaziri Daniel Wilinski Riley KR Woerner Lydia Freddolino Monica Dus Nutrigenomic regulation of sensory plasticity eLife sensory neuroscience gene regulation nutrition |
| title | Nutrigenomic regulation of sensory plasticity |
| title_full | Nutrigenomic regulation of sensory plasticity |
| title_fullStr | Nutrigenomic regulation of sensory plasticity |
| title_full_unstemmed | Nutrigenomic regulation of sensory plasticity |
| title_short | Nutrigenomic regulation of sensory plasticity |
| title_sort | nutrigenomic regulation of sensory plasticity |
| topic | sensory neuroscience gene regulation nutrition |
| url | https://elifesciences.org/articles/83979 |
| work_keys_str_mv | AT hayeonsung nutrigenomicregulationofsensoryplasticity AT anoumidvaziri nutrigenomicregulationofsensoryplasticity AT danielwilinski nutrigenomicregulationofsensoryplasticity AT rileykrwoerner nutrigenomicregulationofsensoryplasticity AT lydiafreddolino nutrigenomicregulationofsensoryplasticity AT monicadus nutrigenomicregulationofsensoryplasticity |