Development of a checklist of standard items for processing individual participant data from randomised trials for meta-analyses: Protocol for a modified e-Delphi study.
Individual participant data meta-analyses enable detailed checking of data quality and more complex analyses than standard study-level synthesis of summary data based on publications. However, there is limited existing guidance on the specific systematic checks that should be undertaken to confirm a...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0275893&type=printable |
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| author | Kylie E Hunter Angela C Webster Mike Clarke Matthew J Page Sol Libesman Peter J Godolphin Mason Aberoumand Larysa H M Rydzewska Rui Wang Aidan C Tan Wentao Li Ben W Mol Melina Willson Vicki Brown Talia Palacios Anna Lene Seidler |
| author_facet | Kylie E Hunter Angela C Webster Mike Clarke Matthew J Page Sol Libesman Peter J Godolphin Mason Aberoumand Larysa H M Rydzewska Rui Wang Aidan C Tan Wentao Li Ben W Mol Melina Willson Vicki Brown Talia Palacios Anna Lene Seidler |
| author_sort | Kylie E Hunter |
| collection | DOAJ |
| description | Individual participant data meta-analyses enable detailed checking of data quality and more complex analyses than standard study-level synthesis of summary data based on publications. However, there is limited existing guidance on the specific systematic checks that should be undertaken to confirm and enhance data quality for individual participant data meta-analyses and how to conduct these checks. We aim to address this gap by developing a checklist of items for data quality checking and cleaning to be applied to individual participant data meta-analyses of randomised trials. This study will comprise three phases: 1) a scoping review to identify potential checklist items; 2) two e-Delphi survey rounds among an invited panel of experts followed by a consensus meeting; and 3) pilot testing and refinement of the checklist, including development of an accompanying R-markdown program to facilitate its uptake. |
| format | Article |
| id | doaj-art-76af1cea82ab468ea5fbe8daaa9b748a |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-76af1cea82ab468ea5fbe8daaa9b748a2025-08-20T02:23:19ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-011710e027589310.1371/journal.pone.0275893Development of a checklist of standard items for processing individual participant data from randomised trials for meta-analyses: Protocol for a modified e-Delphi study.Kylie E HunterAngela C WebsterMike ClarkeMatthew J PageSol LibesmanPeter J GodolphinMason AberoumandLarysa H M RydzewskaRui WangAidan C TanWentao LiBen W MolMelina WillsonVicki BrownTalia PalaciosAnna Lene SeidlerIndividual participant data meta-analyses enable detailed checking of data quality and more complex analyses than standard study-level synthesis of summary data based on publications. However, there is limited existing guidance on the specific systematic checks that should be undertaken to confirm and enhance data quality for individual participant data meta-analyses and how to conduct these checks. We aim to address this gap by developing a checklist of items for data quality checking and cleaning to be applied to individual participant data meta-analyses of randomised trials. This study will comprise three phases: 1) a scoping review to identify potential checklist items; 2) two e-Delphi survey rounds among an invited panel of experts followed by a consensus meeting; and 3) pilot testing and refinement of the checklist, including development of an accompanying R-markdown program to facilitate its uptake.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0275893&type=printable |
| spellingShingle | Kylie E Hunter Angela C Webster Mike Clarke Matthew J Page Sol Libesman Peter J Godolphin Mason Aberoumand Larysa H M Rydzewska Rui Wang Aidan C Tan Wentao Li Ben W Mol Melina Willson Vicki Brown Talia Palacios Anna Lene Seidler Development of a checklist of standard items for processing individual participant data from randomised trials for meta-analyses: Protocol for a modified e-Delphi study. PLoS ONE |
| title | Development of a checklist of standard items for processing individual participant data from randomised trials for meta-analyses: Protocol for a modified e-Delphi study. |
| title_full | Development of a checklist of standard items for processing individual participant data from randomised trials for meta-analyses: Protocol for a modified e-Delphi study. |
| title_fullStr | Development of a checklist of standard items for processing individual participant data from randomised trials for meta-analyses: Protocol for a modified e-Delphi study. |
| title_full_unstemmed | Development of a checklist of standard items for processing individual participant data from randomised trials for meta-analyses: Protocol for a modified e-Delphi study. |
| title_short | Development of a checklist of standard items for processing individual participant data from randomised trials for meta-analyses: Protocol for a modified e-Delphi study. |
| title_sort | development of a checklist of standard items for processing individual participant data from randomised trials for meta analyses protocol for a modified e delphi study |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0275893&type=printable |
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