Analysis of antibacterial agents consumption in a Brazilian southeastern hospital complex from 2018 to 2021
Abstract Healthcare during the COVID-19 pandemic may have led to the inappropriate use of antimicrobial agents and contributed to elevated multidrug resistance. The aim of this study was to analyze the consumption of antibacterial agents at a hospital complex from 2018 to 2021. Drug utilization stud...
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Universidade de São Paulo
2025-01-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502025000100316&lng=en&tlng=en |
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| author | Giuliana Amanda de Oliveira Adriano Max Moreira Reis |
| author_facet | Giuliana Amanda de Oliveira Adriano Max Moreira Reis |
| author_sort | Giuliana Amanda de Oliveira |
| collection | DOAJ |
| description | Abstract Healthcare during the COVID-19 pandemic may have led to the inappropriate use of antimicrobial agents and contributed to elevated multidrug resistance. The aim of this study was to analyze the consumption of antibacterial agents at a hospital complex from 2018 to 2021. Drug utilization study using antibacterial agents consumption data. The groups of antibacterial agents most consumed in the hospital complex were carbapenems, penicillins + beta-lactamase inhibitors, beta-lactamase-resistant penicillins, glycopeptides, and fluoroquinolones. The drugs with a compound annual growth rate that increased by more than 20% from 2018 to 2021 were amikacin (50.12%), benzylpenicillin (24.33%), oral clarithromycin (51.06%), daptomycin (34.38%), polymyxin B (20.85%), and tigecycline (41.49%). According to the AWaRE classification, the antibacterial agents from the Watch group subjected to AWaRE exhibited increased consumption in all years of the study. On the other hand, there was a reduction in the access category. In turn, the consumption of antibacterial agents in the reserve category also increased. The pattern of antimicrobial consumption in the hospital complex showed increased consumption in medical clinics and intensive care units, with a predominance of carbapenems, penicillins + beta-lactamase inhibitors, beta-lactamase-resistant penicillins, glycopeptides, fluoroquinolones, and polymyxin B, reflecting the care profile and influence of the COVID-19 pandemic. |
| format | Article |
| id | doaj-art-76a8ab1af34c461aa38b5deb34e5a220 |
| institution | Kabale University |
| issn | 2175-9790 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj-art-76a8ab1af34c461aa38b5deb34e5a2202025-01-21T07:41:43ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902025-01-016110.1590/s2175-97902025e24118Analysis of antibacterial agents consumption in a Brazilian southeastern hospital complex from 2018 to 2021Giuliana Amanda de Oliveirahttps://orcid.org/0000-0003-4981-6812Adriano Max Moreira Reishttps://orcid.org/0000-0002-0017-7338Abstract Healthcare during the COVID-19 pandemic may have led to the inappropriate use of antimicrobial agents and contributed to elevated multidrug resistance. The aim of this study was to analyze the consumption of antibacterial agents at a hospital complex from 2018 to 2021. Drug utilization study using antibacterial agents consumption data. The groups of antibacterial agents most consumed in the hospital complex were carbapenems, penicillins + beta-lactamase inhibitors, beta-lactamase-resistant penicillins, glycopeptides, and fluoroquinolones. The drugs with a compound annual growth rate that increased by more than 20% from 2018 to 2021 were amikacin (50.12%), benzylpenicillin (24.33%), oral clarithromycin (51.06%), daptomycin (34.38%), polymyxin B (20.85%), and tigecycline (41.49%). According to the AWaRE classification, the antibacterial agents from the Watch group subjected to AWaRE exhibited increased consumption in all years of the study. On the other hand, there was a reduction in the access category. In turn, the consumption of antibacterial agents in the reserve category also increased. The pattern of antimicrobial consumption in the hospital complex showed increased consumption in medical clinics and intensive care units, with a predominance of carbapenems, penicillins + beta-lactamase inhibitors, beta-lactamase-resistant penicillins, glycopeptides, fluoroquinolones, and polymyxin B, reflecting the care profile and influence of the COVID-19 pandemic.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502025000100316&lng=en&tlng=enAntibacterials agentsDefined daily doseHospitalsAntibioticsDrug resistance |
| spellingShingle | Giuliana Amanda de Oliveira Adriano Max Moreira Reis Analysis of antibacterial agents consumption in a Brazilian southeastern hospital complex from 2018 to 2021 Brazilian Journal of Pharmaceutical Sciences Antibacterials agents Defined daily dose Hospitals Antibiotics Drug resistance |
| title | Analysis of antibacterial agents consumption in a Brazilian southeastern hospital complex from 2018 to 2021 |
| title_full | Analysis of antibacterial agents consumption in a Brazilian southeastern hospital complex from 2018 to 2021 |
| title_fullStr | Analysis of antibacterial agents consumption in a Brazilian southeastern hospital complex from 2018 to 2021 |
| title_full_unstemmed | Analysis of antibacterial agents consumption in a Brazilian southeastern hospital complex from 2018 to 2021 |
| title_short | Analysis of antibacterial agents consumption in a Brazilian southeastern hospital complex from 2018 to 2021 |
| title_sort | analysis of antibacterial agents consumption in a brazilian southeastern hospital complex from 2018 to 2021 |
| topic | Antibacterials agents Defined daily dose Hospitals Antibiotics Drug resistance |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502025000100316&lng=en&tlng=en |
| work_keys_str_mv | AT giulianaamandadeoliveira analysisofantibacterialagentsconsumptioninabraziliansoutheasternhospitalcomplexfrom2018to2021 AT adrianomaxmoreirareis analysisofantibacterialagentsconsumptioninabraziliansoutheasternhospitalcomplexfrom2018to2021 |