Rhabdomyolysis as a rare severe complication of statin therapy: differential diagnosis in real clinical practice (a clinical case)
The mechanisms of drug-induced myopathies include direct myotoxicity, immune-mediated and indirect muscle damage. Clinical manifestations range from asymptomatic or minor myalgia and muscle weakness to chronic myopathy with severe weakness and, in rare cases, rhabdomyolysis with release of cellular...
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2025-06-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/3110 |
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| author | A. V. Melekhov S. V. Borisovskaya N. S. Gavrilina I. I. Gaponova I. G. Nikitin O. A. Ettinger |
| author_facet | A. V. Melekhov S. V. Borisovskaya N. S. Gavrilina I. I. Gaponova I. G. Nikitin O. A. Ettinger |
| author_sort | A. V. Melekhov |
| collection | DOAJ |
| description | The mechanisms of drug-induced myopathies include direct myotoxicity, immune-mediated and indirect muscle damage. Clinical manifestations range from asymptomatic or minor myalgia and muscle weakness to chronic myopathy with severe weakness and, in rare cases, rhabdomyolysis with release of cellular breakdown products into the bloodstream and intercellular space. Although muscle symptoms are the most common adverse events when using statins, they do not pose a real threat in most cases. Rhabdomyolysis is an extremely rare complication of statin therapy. The case illustrates the difficulties that arose in the differential diagnosis of rhabdomyolysis etiology in a patient receiving high-dose statin therapy. The widespread use of high-intensity statin therapy, often accompanied by the simultaneous use of ticagrelor and proton pump inhibitors, requires caution regarding treatment safety, particularly in elderly patients. |
| format | Article |
| id | doaj-art-76a0fc4ace1b4e4a8e2d4667d71747df |
| institution | Kabale University |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-76a0fc4ace1b4e4a8e2d4667d71747df2025-08-23T10:00:37ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532025-06-0121217418110.20996/1819-6446-2025-31102276Rhabdomyolysis as a rare severe complication of statin therapy: differential diagnosis in real clinical practice (a clinical case)A. V. Melekhov0S. V. Borisovskaya1N. S. Gavrilina2I. I. Gaponova3I. G. Nikitin4O. A. Ettinger5Pirogov Russian National Research Medical UniversityPirogov Russian National Research Medical University; V. M. Buyanov Clinical HospitalPirogov Russian National Research Medical University; V. M. Buyanov Clinical HospitalCentral Research Institute for EpidemiologyPirogov Russian National Research Medical UniversityPirogov Russian National Research Medical University; V. M. Buyanov Clinical HospitalThe mechanisms of drug-induced myopathies include direct myotoxicity, immune-mediated and indirect muscle damage. Clinical manifestations range from asymptomatic or minor myalgia and muscle weakness to chronic myopathy with severe weakness and, in rare cases, rhabdomyolysis with release of cellular breakdown products into the bloodstream and intercellular space. Although muscle symptoms are the most common adverse events when using statins, they do not pose a real threat in most cases. Rhabdomyolysis is an extremely rare complication of statin therapy. The case illustrates the difficulties that arose in the differential diagnosis of rhabdomyolysis etiology in a patient receiving high-dose statin therapy. The widespread use of high-intensity statin therapy, often accompanied by the simultaneous use of ticagrelor and proton pump inhibitors, requires caution regarding treatment safety, particularly in elderly patients.https://www.rpcardio.online/jour/article/view/3110lipidsstatinshigh-intensity statin therapystatin intolerancestatin-associated muscle symptomsdrug induced myopathystatin-induced myopathyrhabdomyolysisacute renal injury |
| spellingShingle | A. V. Melekhov S. V. Borisovskaya N. S. Gavrilina I. I. Gaponova I. G. Nikitin O. A. Ettinger Rhabdomyolysis as a rare severe complication of statin therapy: differential diagnosis in real clinical practice (a clinical case) Рациональная фармакотерапия в кардиологии lipids statins high-intensity statin therapy statin intolerance statin-associated muscle symptoms drug induced myopathy statin-induced myopathy rhabdomyolysis acute renal injury |
| title | Rhabdomyolysis as a rare severe complication of statin therapy: differential diagnosis in real clinical practice (a clinical case) |
| title_full | Rhabdomyolysis as a rare severe complication of statin therapy: differential diagnosis in real clinical practice (a clinical case) |
| title_fullStr | Rhabdomyolysis as a rare severe complication of statin therapy: differential diagnosis in real clinical practice (a clinical case) |
| title_full_unstemmed | Rhabdomyolysis as a rare severe complication of statin therapy: differential diagnosis in real clinical practice (a clinical case) |
| title_short | Rhabdomyolysis as a rare severe complication of statin therapy: differential diagnosis in real clinical practice (a clinical case) |
| title_sort | rhabdomyolysis as a rare severe complication of statin therapy differential diagnosis in real clinical practice a clinical case |
| topic | lipids statins high-intensity statin therapy statin intolerance statin-associated muscle symptoms drug induced myopathy statin-induced myopathy rhabdomyolysis acute renal injury |
| url | https://www.rpcardio.online/jour/article/view/3110 |
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