Liver under attack: impacts of high-fat diet on murine model

Liver under attack: impacts of high-fat diet on murine model

Abstract At present, non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide, with obesity recognized as a global epidemic and type 2 diabetes a worldwide disease. In this study, 10 C57BL/6 mice were divided into two groups: the control group (SC) and the high-fat die...

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Main Authors: P. F. Peppi, G. A. Lira, L. R. S. Campos, C. R. Santos, E. M. M. Lima, A. R. C. Barreto-Vianna
Format: Article
Language:English
Published: Instituto Internacional de Ecologia 2025-01-01
Series:Brazilian Journal of Biology
Subjects:
hepatic alterations
high-fat diet
metabolic diseases
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842024000101363&lng=en&tlng=en
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Summary:Abstract At present, non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide, with obesity recognized as a global epidemic and type 2 diabetes a worldwide disease. In this study, 10 C57BL/6 mice were divided into two groups: the control group (SC) and the high-fat diet (HF) group. Both groups were fed their respective diets for 8 weeks. The animals were analyzed for body weight, glucose/insulin resistance, hepatic steatosis, and fibrosis to diagnose NAFLD. Results showed that the HF group animals had significantly higher body weight (P<0.0001), glucose resistance (P=0.0002), insulin resistance (P=0.0009), and blood glucose levels (P<0.05) compared to the SC group. The HF group exhibited increased hepatic steatosis (P<0.0001) and fibrosis (P<0.0001) compared to the SC group. These findings led to the conclusion that the animals in the HF group had grade and stage 2 NAFLD. Furthermore, the HF group animals were classified as obese, indicating a higher risk for developing insulin resistance and, subsequently, type 2 diabetes mellitus (T2DM). Understanding the risk factors and complications associated with NAFLD, obesity, and T2DM is crucial for preventing and treating metabolic alterations linked to a high-fat diet.
ISSN:1678-4375

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