Cutibacterium acnes of single locus sequence type clade C strains exhibit low susceptibility to benzoyl peroxide
Background: Cutibacterium acnes plays an important role in acne pathogenesis. Benzoyl peroxide (BPO) exhibits antimicrobial activity against C. acnes. We previously found that no clade C strains, as determined by single locus sequence typing (SLST), were found before the introduction of BPO in Japan...
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Elsevier
2025-06-01
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| Series: | Journal of Global Antimicrobial Resistance |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S221371652500102X |
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| author | Natsumi Sakaguchi Shoji Seyama Ryota Oba Nobukazu Hayashi Hidemasa Nakaminami |
| author_facet | Natsumi Sakaguchi Shoji Seyama Ryota Oba Nobukazu Hayashi Hidemasa Nakaminami |
| author_sort | Natsumi Sakaguchi |
| collection | DOAJ |
| description | Background: Cutibacterium acnes plays an important role in acne pathogenesis. Benzoyl peroxide (BPO) exhibits antimicrobial activity against C. acnes. We previously found that no clade C strains, as determined by single locus sequence typing (SLST), were found before the introduction of BPO in Japan. However, the prevalence of clade C strains increased after its introduction. In this study, we evaluated the susceptibility of C. acnes strains, belonging to different SLST clades, to BPO. Methods: Forty clinical C. acnes isolates from four distinct SLST clades obtained from acne lesions were analyzed. The susceptibility of C. acnes isolates to BPO was evaluated using a time-kill kinetic assay. Results: C. acnes clade C strains were less susceptible to BPO. In addition, the bactericidal effect of BPO was time-dependent across all clade strains. Conclusions: An increase in C. acnes clade C strains may diminish the efficacy of acne treatment. Therefore, the trends in the prevalence of C. acnes clade C strains should be monitored. |
| format | Article |
| id | doaj-art-769d0e4661cf4e22aff1e5f99f2f010e |
| institution | OA Journals |
| issn | 2213-7165 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Global Antimicrobial Resistance |
| spelling | doaj-art-769d0e4661cf4e22aff1e5f99f2f010e2025-08-20T02:35:06ZengElsevierJournal of Global Antimicrobial Resistance2213-71652025-06-014330630810.1016/j.jgar.2025.04.030Cutibacterium acnes of single locus sequence type clade C strains exhibit low susceptibility to benzoyl peroxideNatsumi Sakaguchi0Shoji Seyama1Ryota Oba2Nobukazu Hayashi3Hidemasa Nakaminami4Department of Clinical Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, JapanDepartment of Clinical Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, JapanDepartment of Clinical Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, JapanDepartment of Dermatology, Toranomon Hospital, Minato-ku, Tokyo, JapanDepartment of Clinical Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan; Corresponding author. Mailing address: Hidemasa Nakaminami, Ph.D., Department of Clinical Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan.Background: Cutibacterium acnes plays an important role in acne pathogenesis. Benzoyl peroxide (BPO) exhibits antimicrobial activity against C. acnes. We previously found that no clade C strains, as determined by single locus sequence typing (SLST), were found before the introduction of BPO in Japan. However, the prevalence of clade C strains increased after its introduction. In this study, we evaluated the susceptibility of C. acnes strains, belonging to different SLST clades, to BPO. Methods: Forty clinical C. acnes isolates from four distinct SLST clades obtained from acne lesions were analyzed. The susceptibility of C. acnes isolates to BPO was evaluated using a time-kill kinetic assay. Results: C. acnes clade C strains were less susceptible to BPO. In addition, the bactericidal effect of BPO was time-dependent across all clade strains. Conclusions: An increase in C. acnes clade C strains may diminish the efficacy of acne treatment. Therefore, the trends in the prevalence of C. acnes clade C strains should be monitored.http://www.sciencedirect.com/science/article/pii/S221371652500102XCutibacterium acnesAcne vulgarisBenzoyl peroxideClade C |
| spellingShingle | Natsumi Sakaguchi Shoji Seyama Ryota Oba Nobukazu Hayashi Hidemasa Nakaminami Cutibacterium acnes of single locus sequence type clade C strains exhibit low susceptibility to benzoyl peroxide Journal of Global Antimicrobial Resistance Cutibacterium acnes Acne vulgaris Benzoyl peroxide Clade C |
| title | Cutibacterium acnes of single locus sequence type clade C strains exhibit low susceptibility to benzoyl peroxide |
| title_full | Cutibacterium acnes of single locus sequence type clade C strains exhibit low susceptibility to benzoyl peroxide |
| title_fullStr | Cutibacterium acnes of single locus sequence type clade C strains exhibit low susceptibility to benzoyl peroxide |
| title_full_unstemmed | Cutibacterium acnes of single locus sequence type clade C strains exhibit low susceptibility to benzoyl peroxide |
| title_short | Cutibacterium acnes of single locus sequence type clade C strains exhibit low susceptibility to benzoyl peroxide |
| title_sort | cutibacterium acnes of single locus sequence type clade c strains exhibit low susceptibility to benzoyl peroxide |
| topic | Cutibacterium acnes Acne vulgaris Benzoyl peroxide Clade C |
| url | http://www.sciencedirect.com/science/article/pii/S221371652500102X |
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