Large Format Histology May Aid in the Detection of Unsuspected Pathologic Findings of Potential Clinical Significance: A Prospective Multiyear Single Institution Study
Large format histology offers several unique advantages over traditional tissue processing. Over 12 years of experience with this technique provide insight into its limitations and benefits. We conducted a prospective multiyear analysis of the potential advantages of large format histology. 656 case...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.1155/2012/532547 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850219891042287616 |
|---|---|
| author | Matthew R. Foster Lauren Harris Karl W. Biesemier |
| author_facet | Matthew R. Foster Lauren Harris Karl W. Biesemier |
| author_sort | Matthew R. Foster |
| collection | DOAJ |
| description | Large format histology offers several unique advantages over traditional tissue processing. Over 12 years of experience with this technique provide insight into its limitations and benefits. We conducted a prospective multiyear analysis of the potential advantages of large format histology. 656 cases were examined prospectively over an eight-year period. In 172 cases the sign-out pathologist documented an unexpected finding of potential clinical significance as present only on the large format sections and not present on the accompanying standard format slides. These include closer margins, a change in size or extent of disease, and previously undocumented invasive and/or in situ carcinoma. Based on over a decade of experience and eight years of data, our results demonstrate that a quarter of cases had an unexpected finding of potential clinical significance that may not have been fully realized without the use of the large format technique. |
| format | Article |
| id | doaj-art-76993f64eba24e53ac7304e10a6dfb6b |
| institution | OA Journals |
| issn | 2090-3170 2090-3189 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj-art-76993f64eba24e53ac7304e10a6dfb6b2025-08-20T02:07:14ZengWileyInternational Journal of Breast Cancer2090-31702090-31892012-01-01201210.1155/2012/532547532547Large Format Histology May Aid in the Detection of Unsuspected Pathologic Findings of Potential Clinical Significance: A Prospective Multiyear Single Institution StudyMatthew R. Foster0Lauren Harris1Karl W. Biesemier2Department of Pathology, Centra Health and Pathology Consultants of Central Virginia, 1914 Thompson Drive, Lynchburg, VA 24501, USADepartment of Pathology, Centra Health and Pathology Consultants of Central Virginia, 1914 Thompson Drive, Lynchburg, VA 24501, USADepartment of Pathology, Centra Health and Pathology Consultants of Central Virginia, 1914 Thompson Drive, Lynchburg, VA 24501, USALarge format histology offers several unique advantages over traditional tissue processing. Over 12 years of experience with this technique provide insight into its limitations and benefits. We conducted a prospective multiyear analysis of the potential advantages of large format histology. 656 cases were examined prospectively over an eight-year period. In 172 cases the sign-out pathologist documented an unexpected finding of potential clinical significance as present only on the large format sections and not present on the accompanying standard format slides. These include closer margins, a change in size or extent of disease, and previously undocumented invasive and/or in situ carcinoma. Based on over a decade of experience and eight years of data, our results demonstrate that a quarter of cases had an unexpected finding of potential clinical significance that may not have been fully realized without the use of the large format technique.http://dx.doi.org/10.1155/2012/532547 |
| spellingShingle | Matthew R. Foster Lauren Harris Karl W. Biesemier Large Format Histology May Aid in the Detection of Unsuspected Pathologic Findings of Potential Clinical Significance: A Prospective Multiyear Single Institution Study International Journal of Breast Cancer |
| title | Large Format Histology May Aid in the Detection of Unsuspected Pathologic Findings of Potential Clinical Significance: A Prospective Multiyear Single Institution Study |
| title_full | Large Format Histology May Aid in the Detection of Unsuspected Pathologic Findings of Potential Clinical Significance: A Prospective Multiyear Single Institution Study |
| title_fullStr | Large Format Histology May Aid in the Detection of Unsuspected Pathologic Findings of Potential Clinical Significance: A Prospective Multiyear Single Institution Study |
| title_full_unstemmed | Large Format Histology May Aid in the Detection of Unsuspected Pathologic Findings of Potential Clinical Significance: A Prospective Multiyear Single Institution Study |
| title_short | Large Format Histology May Aid in the Detection of Unsuspected Pathologic Findings of Potential Clinical Significance: A Prospective Multiyear Single Institution Study |
| title_sort | large format histology may aid in the detection of unsuspected pathologic findings of potential clinical significance a prospective multiyear single institution study |
| url | http://dx.doi.org/10.1155/2012/532547 |
| work_keys_str_mv | AT matthewrfoster largeformathistologymayaidinthedetectionofunsuspectedpathologicfindingsofpotentialclinicalsignificanceaprospectivemultiyearsingleinstitutionstudy AT laurenharris largeformathistologymayaidinthedetectionofunsuspectedpathologicfindingsofpotentialclinicalsignificanceaprospectivemultiyearsingleinstitutionstudy AT karlwbiesemier largeformathistologymayaidinthedetectionofunsuspectedpathologicfindingsofpotentialclinicalsignificanceaprospectivemultiyearsingleinstitutionstudy |