Multimodal Coherent Anti-Stokes Raman Scattering Microscopy With a Supercontinuum All-Fiber Laser
We demonstrate a compact supercontinuum (SC) all-fiber laser source for multimodal coherent anti-Stokes Raman scattering (CARS) microscopy based on an Er-fiber seed. It can be used in both high-speed narrowband CARS microscopy and broadband CARS spectroscopy at tens of milliseconds per pixel, by sim...
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IEEE
2019-01-01
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| Series: | IEEE Photonics Journal |
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| Online Access: | https://ieeexplore.ieee.org/document/8648457/ |
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| author | Yan Li Xiaosheng Xiao Jingjing Guo Kangjun Zhao Shunyu Yao Lili Gui Changxi Yang |
| author_facet | Yan Li Xiaosheng Xiao Jingjing Guo Kangjun Zhao Shunyu Yao Lili Gui Changxi Yang |
| author_sort | Yan Li |
| collection | DOAJ |
| description | We demonstrate a compact supercontinuum (SC) all-fiber laser source for multimodal coherent anti-Stokes Raman scattering (CARS) microscopy based on an Er-fiber seed. It can be used in both high-speed narrowband CARS microscopy and broadband CARS spectroscopy at tens of milliseconds per pixel, by simply switching without realignment. The common pump pulses, generated from the SC in a highly nonlinear fiber (HNLF), are obtained after spectral filtering. The central wavelength of pump pulses is 1067.2 nm with a bandwidth of 0.8 nm, which provides a high-spectral resolution (<10 cm<sup>–1</sup>). By combining with the narrowband Stokes beam, which is directly obtained from the Er-fiber oscillator around ∼1550 nm, we can achieve a narrowband CARS microscopy in frequency shifts of ∼2700 to ∼3200 cm<sup>–1</sup>. The SC Stokes beam in a broadband CARS spectroscopy ranging from 1150 to beyond 1700 nm is generated in an HNLF, with vibrational spectra over a bandwidth of more than 2800 cm<sup>–1</sup>. We also analyzed the influences of different HNLFs on the SC generation both in simulation and experiment. The capability of our system in a multimodal CARS microscopy is demonstrated by the CARS detection of polystyrene and pork. |
| format | Article |
| id | doaj-art-7697cf5b0e2f4b038dc01ba5870e04cc |
| institution | Kabale University |
| issn | 1943-0655 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | IEEE |
| record_format | Article |
| series | IEEE Photonics Journal |
| spelling | doaj-art-7697cf5b0e2f4b038dc01ba5870e04cc2025-08-20T03:30:51ZengIEEEIEEE Photonics Journal1943-06552019-01-011121810.1109/JPHOT.2019.28982228648457Multimodal Coherent Anti-Stokes Raman Scattering Microscopy With a Supercontinuum All-Fiber LaserYan Li0Xiaosheng Xiao1https://orcid.org/0000-0002-9368-9956Jingjing Guo2Kangjun Zhao3Shunyu Yao4Lili Gui5https://orcid.org/0000-0002-3710-6330Changxi Yang6https://orcid.org/0000-0002-9972-6965State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instruments, Tsinghua University, Beijing, ChinaState Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instruments, Tsinghua University, Beijing, ChinaState Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instruments, Tsinghua University, Beijing, ChinaState Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instruments, Tsinghua University, Beijing, ChinaState Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instruments, Tsinghua University, Beijing, China4th Physics Institute and Research Center SCoPE, University of Stuttgart, Stuttgart, GermanyState Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instruments, Tsinghua University, Beijing, ChinaWe demonstrate a compact supercontinuum (SC) all-fiber laser source for multimodal coherent anti-Stokes Raman scattering (CARS) microscopy based on an Er-fiber seed. It can be used in both high-speed narrowband CARS microscopy and broadband CARS spectroscopy at tens of milliseconds per pixel, by simply switching without realignment. The common pump pulses, generated from the SC in a highly nonlinear fiber (HNLF), are obtained after spectral filtering. The central wavelength of pump pulses is 1067.2 nm with a bandwidth of 0.8 nm, which provides a high-spectral resolution (<10 cm<sup>–1</sup>). By combining with the narrowband Stokes beam, which is directly obtained from the Er-fiber oscillator around ∼1550 nm, we can achieve a narrowband CARS microscopy in frequency shifts of ∼2700 to ∼3200 cm<sup>–1</sup>. The SC Stokes beam in a broadband CARS spectroscopy ranging from 1150 to beyond 1700 nm is generated in an HNLF, with vibrational spectra over a bandwidth of more than 2800 cm<sup>–1</sup>. We also analyzed the influences of different HNLFs on the SC generation both in simulation and experiment. The capability of our system in a multimodal CARS microscopy is demonstrated by the CARS detection of polystyrene and pork.https://ieeexplore.ieee.org/document/8648457/Fiber lasersnonlinear opticssupercontinuum generationRaman scattering |
| spellingShingle | Yan Li Xiaosheng Xiao Jingjing Guo Kangjun Zhao Shunyu Yao Lili Gui Changxi Yang Multimodal Coherent Anti-Stokes Raman Scattering Microscopy With a Supercontinuum All-Fiber Laser IEEE Photonics Journal Fiber lasers nonlinear optics supercontinuum generation Raman scattering |
| title | Multimodal Coherent Anti-Stokes Raman Scattering Microscopy With a Supercontinuum All-Fiber Laser |
| title_full | Multimodal Coherent Anti-Stokes Raman Scattering Microscopy With a Supercontinuum All-Fiber Laser |
| title_fullStr | Multimodal Coherent Anti-Stokes Raman Scattering Microscopy With a Supercontinuum All-Fiber Laser |
| title_full_unstemmed | Multimodal Coherent Anti-Stokes Raman Scattering Microscopy With a Supercontinuum All-Fiber Laser |
| title_short | Multimodal Coherent Anti-Stokes Raman Scattering Microscopy With a Supercontinuum All-Fiber Laser |
| title_sort | multimodal coherent anti stokes raman scattering microscopy with a supercontinuum all fiber laser |
| topic | Fiber lasers nonlinear optics supercontinuum generation Raman scattering |
| url | https://ieeexplore.ieee.org/document/8648457/ |
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