UV Spectrophotometric Method for the Estimation of Valacyclovir HCl in Tablet Dosage Form
A simple, sensitive, highly accurate UV spectrophotometric method has been developed for the determination of valacyclovir in bulk and tablet dosage form. Solution of valacyclovir in 0.1N HCl shows maximum absorbance at 255 nm. Beer’s law was obeyed in the concentration range of 5-25 mcg mL-1 with 1...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2009/546187 |
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| author | M. Ganesh C. V. Narasimharao A. Saravana Kumar K. Kamalakannan M. Vinoba H. S. Mahajan T. Sivakumar |
| author_facet | M. Ganesh C. V. Narasimharao A. Saravana Kumar K. Kamalakannan M. Vinoba H. S. Mahajan T. Sivakumar |
| author_sort | M. Ganesh |
| collection | DOAJ |
| description | A simple, sensitive, highly accurate UV spectrophotometric method has been developed for the determination of valacyclovir in bulk and tablet dosage form. Solution of valacyclovir in 0.1N HCl shows maximum absorbance at 255 nm. Beer’s law was obeyed in the concentration range of 5-25 mcg mL-1 with 1.0910x104 mol-1 cm-1, the slope, intercept, correlation coefficient, detection and quantitation limits were also calculated. The proposed method has been applied successfully for the analysis of the drug in pure and in its tablets dosage forms. Result of percentage recovery and placebo interference shows that the method was not affected by the presence of common excipients. The percentages assay of valacyclovir HCl in tablet was 99.82%. The method was validated by determining its sensitivity, accuracy and precision which proves suitability of the developed method for the routine estimation of valacyclovir in bulk and solid dosage form. |
| format | Article |
| id | doaj-art-7686ef60e23f46268ada17aa542b39e7 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-7686ef60e23f46268ada17aa542b39e72025-02-03T05:59:26ZengWileyE-Journal of Chemistry0973-49452090-98102009-01-016381481810.1155/2009/546187UV Spectrophotometric Method for the Estimation of Valacyclovir HCl in Tablet Dosage FormM. Ganesh0C. V. Narasimharao1A. Saravana Kumar2K. Kamalakannan3M. Vinoba4H. S. Mahajan5T. Sivakumar6Department of Pharmaceutical Analysis, Nandha College of Pharmacy, Erode-638 052, IndiaDepartment of Pharmaceutical Analysis, Nandha College of Pharmacy, Erode-638 052, IndiaDepartment of Pharmaceutical Analysis, Nandha College of Pharmacy, Erode-638 052, IndiaDepartment of Pharmaceutical Analysis, Nandha College of Pharmacy, Erode-638 052, IndiaDepartment of Chemical Engineering, Alagappa College of Technology, Anna University, Guindy, Chennai-600 025, Tamilnadu, IndiaDepartment of Pharmaceutical Analysis, Nandha College of Pharmacy, Erode-638 052, IndiaDepartment of Pharmaceutical Analysis, Nandha College of Pharmacy, Erode-638 052, IndiaA simple, sensitive, highly accurate UV spectrophotometric method has been developed for the determination of valacyclovir in bulk and tablet dosage form. Solution of valacyclovir in 0.1N HCl shows maximum absorbance at 255 nm. Beer’s law was obeyed in the concentration range of 5-25 mcg mL-1 with 1.0910x104 mol-1 cm-1, the slope, intercept, correlation coefficient, detection and quantitation limits were also calculated. The proposed method has been applied successfully for the analysis of the drug in pure and in its tablets dosage forms. Result of percentage recovery and placebo interference shows that the method was not affected by the presence of common excipients. The percentages assay of valacyclovir HCl in tablet was 99.82%. The method was validated by determining its sensitivity, accuracy and precision which proves suitability of the developed method for the routine estimation of valacyclovir in bulk and solid dosage form.http://dx.doi.org/10.1155/2009/546187 |
| spellingShingle | M. Ganesh C. V. Narasimharao A. Saravana Kumar K. Kamalakannan M. Vinoba H. S. Mahajan T. Sivakumar UV Spectrophotometric Method for the Estimation of Valacyclovir HCl in Tablet Dosage Form E-Journal of Chemistry |
| title | UV Spectrophotometric Method for the Estimation of Valacyclovir HCl in Tablet Dosage Form |
| title_full | UV Spectrophotometric Method for the Estimation of Valacyclovir HCl in Tablet Dosage Form |
| title_fullStr | UV Spectrophotometric Method for the Estimation of Valacyclovir HCl in Tablet Dosage Form |
| title_full_unstemmed | UV Spectrophotometric Method for the Estimation of Valacyclovir HCl in Tablet Dosage Form |
| title_short | UV Spectrophotometric Method for the Estimation of Valacyclovir HCl in Tablet Dosage Form |
| title_sort | uv spectrophotometric method for the estimation of valacyclovir hcl in tablet dosage form |
| url | http://dx.doi.org/10.1155/2009/546187 |
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