Investigating the role of hyperexpressed HCN1 in inducing myocardial infarction through activation of the NF-κB signaling pathway

Investigating the role of hyperexpressed HCN1 in inducing myocardial infarction through activation of the NF-κB signaling pathway

We investigated the protective effect of the NF-κB inhibitor, pyrrolidine dithiocarbamate (PDTC) on cardiomyocyte injury induced by HCN1 channel overexpression, and explored the underlying mechanisms. An HCN1 overexpression vector was constructed and transfected into H9C2 cells, followed by PDTC tre...

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Bibliographic Details
Main Authors: Liang Xiao, Zhang Jie, Luo Ya
Format: Article
Language:English
Published: De Gruyter 2024-12-01
Series:Open Life Sciences
Subjects:
hcn1
ikkβ
myocardial infarction
nf-κb
pdtc
Online Access:https://doi.org/10.1515/biol-2022-0967
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