The effect of melatonin on coagulation parameters in rats with cerulein-induced acute pancreatitis
<b>Aim:</b> The aim of this study was to evaluate possible effects of melatonin on coagulation parameters in rats with cerulein induced acute pancreatitis.<p> <b>Materials and Methods: </b>For this purpose, 32 adult, male, healthy Wistar Abino rats were used. The animal...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1243 |
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| Summary: | <b>Aim:</b> The aim of this study was to evaluate possible effects
of melatonin on coagulation parameters in rats with cerulein
induced acute pancreatitis.<p>
<b>Materials and Methods: </b>For this purpose, 32 adult, male,
healthy Wistar Abino rats were used. The animals were divided
into four groups. Group I animals was no applied. Group
II animals was intraperitoneally administered 50 mg/kg melatonin
per rat twice for two hours intervals. Animals of group
III received two intraperitoneal injections of cerulein (50
μg/kg and 25 μg/kg bw, respectively) at two hours intervals.
Animals of group IV received two intraperitoneal injections
of cerulein (50 μg/kg and 25 μg/kg bw, respectively) at two
hours intervals and the rats received an intraperitoneal injection
of 50 mg/kg melatonin 30 min before each cerulein
injection. In blood samples taken from all animals, platelet,
fibrinogen, activated partial thromboplastin time (APTT),
prothrombin time (PT), international normalized ratio (INR)
levels were determined.<p>
<b>Results: </b>Acute pancreatitis caused increment in platelet count
and fibrinogen level compared to control group (p<0.05).
APTT, PT and INR were significantly shortened with acute
pancreatitis in comparison with control group (p<0.05).
Melatonin application to rats with acute pancreatitis importantly
lengthened PT and INR compared to acute pancreatitis
group (p<0.05).<p>
<b>Conclusion:</b> We concluded that melatonin may be alleviated
the abnormalities in coagulation parameters resulting from
acute pancreatitis. |
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| ISSN: | 1309-6958 2146-1953 |