Valproic acid improves the efficacy of oxaliplatin/fluoropyrimidine-based chemotherapy by targeting cancer stem cell via β-Catenin modulation in colorectal cancer

Valproic acid improves the efficacy of oxaliplatin/fluoropyrimidine-based chemotherapy by targeting cancer stem cell via β-Catenin modulation in colorectal cancer

Abstract Despite advances in systemic therapeutic approaches, metastatic colorectal cancer (mCRC) patients harboring BRAF or RAS mutations have poor outcomes. Cancer stem cells (CSCs) play central roles in drug resistance and CRC recurrence. Therefore, targeting the epigenetic mechanisms that sustai...

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Main Authors: Maria Serena Roca, Rita Lombardi, Cristina Testa, Federica Iannelli, Laura Grumetti, Tania Moccia, Veronica Barile, Laura Addi, Domenico Memoli, Alessandra Leone, Simone Di Franco, Giorgio Stassi, Antonio Avallone, Francesca Bruzzese, Biagio Pucci, Alfredo Budillon, Elena Di Gennaro
Format: Article
Language:English
Published: Nature Publishing Group 2025-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07902-8
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