Comparison of Optical Coherence Tomography Features of Vogt–Koyanagi–Harada Disease and Central Serous Chorioretinopathy
Purpose: The purpose of the study was to compare and analyze the optical coherence tomography (OCT) features of Vogt–Koyanagi–Harada disease (VKH) and central serous chorioretinopathy (CSCR). Materials and Methods: A retrospective review of OCT records was done for eyes with VKH and CSCR. We enrolle...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-04-01
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| Series: | Delhi Journal of Ophthalmology |
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| Online Access: | https://journals.lww.com/10.4103/DLJO.DLJO_118_24 |
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| author | Chanda Gupta Aditi Singal Manisha Agarwal |
| author_facet | Chanda Gupta Aditi Singal Manisha Agarwal |
| author_sort | Chanda Gupta |
| collection | DOAJ |
| description | Purpose:
The purpose of the study was to compare and analyze the optical coherence tomography (OCT) features of Vogt–Koyanagi–Harada disease (VKH) and central serous chorioretinopathy (CSCR).
Materials and Methods:
A retrospective review of OCT records was done for eyes with VKH and CSCR. We enrolled 50 eyes that presented to us with CSCR and 35 eyes with VKH. Various OCT features were analyzed using a two-tailed Z test between the two diseases. P <0.05 was considered to be statistically significant.
Results:
The mean age of patients with VKH was 37.0 ± 8.2 (21–49) years, and patients with CSR were 39.5 ± 6.7 (29–60) years. There was a male predominance in the CSR group, which was not found in the VKH group (91.3% in CSR vs. 36.8% in VKH). Subretinal fluid was noted in all the cases of VKH (100%) and CSCR (100%). Patients with VKH had a higher probability of exhibiting features such as hyperreflective dots in the vitreous, internal limiting membrane fluctuation, intraretinal fluid accumulation, bacillary layer detachment, subretinal hyperreflective dots, subretinal septae, retinal pigment epithelium (RPE) folds, and granular surface of RPE (P < 0.05). Pigment epithelium detachment was noted in a higher probability in cases of CSCR than VKH (P < 0.05). The mean foveal thickness noted in eyes with CSCR was lower at 405.56 ± 18.33 µm (microns) than in VKH at 552.14 ± 65.58 µm (P = 0.03).
Conclusion:
CSCR and VKH share certain OCT characteristic features; however, they may be more commonly seen in one condition as opposed to the other. |
| format | Article |
| id | doaj-art-767fccf66b394af3aea270a929e31fbb |
| institution | DOAJ |
| issn | 0972-0200 2454-2784 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Delhi Journal of Ophthalmology |
| spelling | doaj-art-767fccf66b394af3aea270a929e31fbb2025-08-20T03:16:07ZengWolters Kluwer Medknow PublicationsDelhi Journal of Ophthalmology0972-02002454-27842025-04-0135212012410.4103/DLJO.DLJO_118_24Comparison of Optical Coherence Tomography Features of Vogt–Koyanagi–Harada Disease and Central Serous ChorioretinopathyChanda GuptaAditi SingalManisha AgarwalPurpose: The purpose of the study was to compare and analyze the optical coherence tomography (OCT) features of Vogt–Koyanagi–Harada disease (VKH) and central serous chorioretinopathy (CSCR). Materials and Methods: A retrospective review of OCT records was done for eyes with VKH and CSCR. We enrolled 50 eyes that presented to us with CSCR and 35 eyes with VKH. Various OCT features were analyzed using a two-tailed Z test between the two diseases. P <0.05 was considered to be statistically significant. Results: The mean age of patients with VKH was 37.0 ± 8.2 (21–49) years, and patients with CSR were 39.5 ± 6.7 (29–60) years. There was a male predominance in the CSR group, which was not found in the VKH group (91.3% in CSR vs. 36.8% in VKH). Subretinal fluid was noted in all the cases of VKH (100%) and CSCR (100%). Patients with VKH had a higher probability of exhibiting features such as hyperreflective dots in the vitreous, internal limiting membrane fluctuation, intraretinal fluid accumulation, bacillary layer detachment, subretinal hyperreflective dots, subretinal septae, retinal pigment epithelium (RPE) folds, and granular surface of RPE (P < 0.05). Pigment epithelium detachment was noted in a higher probability in cases of CSCR than VKH (P < 0.05). The mean foveal thickness noted in eyes with CSCR was lower at 405.56 ± 18.33 µm (microns) than in VKH at 552.14 ± 65.58 µm (P = 0.03). Conclusion: CSCR and VKH share certain OCT characteristic features; however, they may be more commonly seen in one condition as opposed to the other.https://journals.lww.com/10.4103/DLJO.DLJO_118_24central foveal thicknesscentral serous chorioretinopathyfundus fluorescein angiographyhigh definitionindocyanine green angiographyinner and outer segmentsinternal limiting membranelogarithm of the minimal angle of resolutionoptical coherence tomographypigment epithelium detachmentretinal pigment epitheliumstandard deviationsub-retinal fluidvogt–koyanagi–harada disease |
| spellingShingle | Chanda Gupta Aditi Singal Manisha Agarwal Comparison of Optical Coherence Tomography Features of Vogt–Koyanagi–Harada Disease and Central Serous Chorioretinopathy Delhi Journal of Ophthalmology central foveal thickness central serous chorioretinopathy fundus fluorescein angiography high definition indocyanine green angiography inner and outer segments internal limiting membrane logarithm of the minimal angle of resolution optical coherence tomography pigment epithelium detachment retinal pigment epithelium standard deviation sub-retinal fluid vogt–koyanagi–harada disease |
| title | Comparison of Optical Coherence Tomography Features of Vogt–Koyanagi–Harada Disease and Central Serous Chorioretinopathy |
| title_full | Comparison of Optical Coherence Tomography Features of Vogt–Koyanagi–Harada Disease and Central Serous Chorioretinopathy |
| title_fullStr | Comparison of Optical Coherence Tomography Features of Vogt–Koyanagi–Harada Disease and Central Serous Chorioretinopathy |
| title_full_unstemmed | Comparison of Optical Coherence Tomography Features of Vogt–Koyanagi–Harada Disease and Central Serous Chorioretinopathy |
| title_short | Comparison of Optical Coherence Tomography Features of Vogt–Koyanagi–Harada Disease and Central Serous Chorioretinopathy |
| title_sort | comparison of optical coherence tomography features of vogt koyanagi harada disease and central serous chorioretinopathy |
| topic | central foveal thickness central serous chorioretinopathy fundus fluorescein angiography high definition indocyanine green angiography inner and outer segments internal limiting membrane logarithm of the minimal angle of resolution optical coherence tomography pigment epithelium detachment retinal pigment epithelium standard deviation sub-retinal fluid vogt–koyanagi–harada disease |
| url | https://journals.lww.com/10.4103/DLJO.DLJO_118_24 |
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