The Importance of C4d in Biopsies of Kidney Transplant Recipients
Antibody-mediated rejection (AMR) is highly detrimental to the prolonged survival of transplanted kidneys. C4d has been regarded as a footprint of AMR tissue damage, and the introduction of C4d staining in daily clinical practice aroused an ever-increasing interest in the role of antibody-mediated m...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/678180 |
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| _version_ | 1832558665105670144 |
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| author | Rosana Rosa Miranda Corrêa Juliana Reis Machado Marcos Vinícius da Silva Fernanda Rodrigues Helmo Camila Souza Oliveira Guimarães Laura Penna Rocha Ana Carolina Guimarães Faleiros Marlene Antônia dos Reis |
| author_facet | Rosana Rosa Miranda Corrêa Juliana Reis Machado Marcos Vinícius da Silva Fernanda Rodrigues Helmo Camila Souza Oliveira Guimarães Laura Penna Rocha Ana Carolina Guimarães Faleiros Marlene Antônia dos Reis |
| author_sort | Rosana Rosa Miranda Corrêa |
| collection | DOAJ |
| description | Antibody-mediated rejection (AMR) is highly detrimental to the prolonged survival of transplanted kidneys. C4d has been regarded as a footprint of AMR tissue damage, and the introduction of C4d staining in daily clinical practice aroused an ever-increasing interest in the role of antibody-mediated mechanisms in allograft rejection. Despite the general acceptance of the usefulness of C4d in the identification of acute AMR, the data for C4d staining in chronic AMR is variable. The presence of C4d in the majority of the biopsies with features of chronic antibody-mediated rejection is reported, but this rejection without C4d staining is observed as well, suggesting that C4d is specific but not sensitive. Further studies on AMR with positive C4d staining in biopsy specimens are really important, as well as the study of novel routine markers that may participate in the pathogenesis of this process. |
| format | Article |
| id | doaj-art-767d9207b54943578520735d0b288dc2 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-767d9207b54943578520735d0b288dc22025-02-03T01:31:56ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/678180678180The Importance of C4d in Biopsies of Kidney Transplant RecipientsRosana Rosa Miranda Corrêa0Juliana Reis Machado1Marcos Vinícius da Silva2Fernanda Rodrigues Helmo3Camila Souza Oliveira Guimarães4Laura Penna Rocha5Ana Carolina Guimarães Faleiros6Marlene Antônia dos Reis7Discipline of General Pathology, Nephropathology Service, Federal University of Triângulo Mineiro, Frei Paulino, 30, 38025-180 Uberaba, BrazilDiscipline of General Pathology, Nephropathology Service, Federal University of Triângulo Mineiro, Frei Paulino, 30, 38025-180 Uberaba, BrazilDiscipline of Immunology, Federal University of Triângulo Mineiro, Frei Paulino, 30, 38025-180 Uberaba, BrazilDiscipline of General Pathology, Nephropathology Service, Federal University of Triângulo Mineiro, Frei Paulino, 30, 38025-180 Uberaba, BrazilDiscipline of General Pathology, Nephropathology Service, Federal University of Triângulo Mineiro, Frei Paulino, 30, 38025-180 Uberaba, BrazilDiscipline of General Pathology, Nephropathology Service, Federal University of Triângulo Mineiro, Frei Paulino, 30, 38025-180 Uberaba, BrazilDiscipline of Cell Biology, Federal University of Triângulo Mineiro, Frei Paulino, 30, 38025-180 Uberaba, BrazilDiscipline of General Pathology, Nephropathology Service, Federal University of Triângulo Mineiro, Frei Paulino, 30, 38025-180 Uberaba, BrazilAntibody-mediated rejection (AMR) is highly detrimental to the prolonged survival of transplanted kidneys. C4d has been regarded as a footprint of AMR tissue damage, and the introduction of C4d staining in daily clinical practice aroused an ever-increasing interest in the role of antibody-mediated mechanisms in allograft rejection. Despite the general acceptance of the usefulness of C4d in the identification of acute AMR, the data for C4d staining in chronic AMR is variable. The presence of C4d in the majority of the biopsies with features of chronic antibody-mediated rejection is reported, but this rejection without C4d staining is observed as well, suggesting that C4d is specific but not sensitive. Further studies on AMR with positive C4d staining in biopsy specimens are really important, as well as the study of novel routine markers that may participate in the pathogenesis of this process.http://dx.doi.org/10.1155/2013/678180 |
| spellingShingle | Rosana Rosa Miranda Corrêa Juliana Reis Machado Marcos Vinícius da Silva Fernanda Rodrigues Helmo Camila Souza Oliveira Guimarães Laura Penna Rocha Ana Carolina Guimarães Faleiros Marlene Antônia dos Reis The Importance of C4d in Biopsies of Kidney Transplant Recipients Clinical and Developmental Immunology |
| title | The Importance of C4d in Biopsies of Kidney Transplant Recipients |
| title_full | The Importance of C4d in Biopsies of Kidney Transplant Recipients |
| title_fullStr | The Importance of C4d in Biopsies of Kidney Transplant Recipients |
| title_full_unstemmed | The Importance of C4d in Biopsies of Kidney Transplant Recipients |
| title_short | The Importance of C4d in Biopsies of Kidney Transplant Recipients |
| title_sort | importance of c4d in biopsies of kidney transplant recipients |
| url | http://dx.doi.org/10.1155/2013/678180 |
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