A new hERG allosteric modulator rescues genetic and drug‐induced long‐QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells

A new hERG allosteric modulator rescues genetic and drug‐induced long‐QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells

Abstract Long‐QT syndrome (LQTS) is an arrhythmogenic disorder characterised by prolongation of the QT interval in the electrocardiogram, which can lead to sudden cardiac death. Pharmacological treatments are far from optimal for congenital forms of LQTS, while the acquired form, often triggered by...

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Bibliographic Details
Main Authors: Luca Sala, Zhiyi Yu, Dorien Ward‐van Oostwaard, Jacobus PD van Veldhoven, Alessandra Moretti, Karl‐Ludwig Laugwitz, Christine L Mummery, Adriaan P IJzerman, Milena Bellin
Format: Article
Language:English
Published: Springer Nature 2016-07-01
Series:EMBO Molecular Medicine
Subjects:
cardiac arrhythmia
drug screening
hERG
human induced pluripotent stem cells
long‐QT syndrome
Online Access:https://doi.org/10.15252/emmm.201606260
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