Features of the reaction of the sympathoadrenal system in patients with depressive disorder after myocardial revascularization
Objective: to identify the infl uence of depression in patients with coronary heart disease myocardial infarction after myocardial revascularization on sympathoadrenal system. Material and Methods: 95 patients with coronary artery disease after surgery – revascularization were included into the st...
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| Format: | Article |
| Language: | English |
| Published: |
Zaporizhzhia State Medical and Pharmaceutical University
2016-06-01
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| Series: | Zaporožskij Medicinskij Žurnal |
| Subjects: | |
| Online Access: | http://zmj.zsmu.edu.ua/article/view/76916/73873 |
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| Summary: | Objective: to identify the infl uence of depression in patients with coronary heart disease myocardial infarction after myocardial revascularization
on sympathoadrenal system.
Material and Methods: 95 patients with coronary artery disease after surgery – revascularization were included into the study. The presence
of depressive state was found in 56 patients, 39 patients were free of depression. In addition to a thorough clinical examination, all patients with
postinfarction cardiosclerosis undergone echocardiography of the heart (echocardiography), ambulatory Holter ECG monitoring (ECG HM),
and carried out tests on the scale of the HADS, Beck to determine the mental state at the moment, as well as testing on the scale of quality of
life SF-36.
Results and discussion: it is known that patients with depression observed hyperactivation of the sympathoadrenal system (SAS), increased
levels of circulating plasma epinephrine and norepinephrine, resulting in a relative tachycardia, increased myocardial oxygen consumption,
to changes in the hemostatic system and along with hypercortisolemic to hypertension. In addition, it was shown that over-activation of the
sympathoadrenal system can lead to severe systolic left ventricular dysfunction even in patients without coronary artery disease. Conclusions: Identifi cation of catecholamine levels in patients with coronary artery disease and postinfarction cardiosclerosis after myocardial
revascularization is an important diagnostic criterion for the activation of the sympathoadrenal system.
Levels of daily excretion of adrenaline (18.6 ±1.14 mg/day); noradrenaline (39.14±2.10 mg/day); and dopamine (336.63±8.47 mg/day) were
signifi cantly higher in patients with depression. |
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| ISSN: | 2306-4145 2310-1210 |