Significance Evaluating Coagulation-Fibrinolysis Dynamics in Chronic Thromboembolic Pulmonary Disease With Pulmonary Hypertension Caused by Heritable Thrombophilias: A Case Series
Precisely evaluating coagulation ability is crucial for managing hypercoagulation. Antithrombin resistance is a disease in which a missense variant of the prothrombin gene, prothrombin Yukuhashi, occurs in a hypercoagulation state. We present 2 parent-child cases of antithrombin resistance-induced c...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American College of Physicians
2024-11-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2024.0440 |
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| Summary: | Precisely evaluating coagulation ability is crucial for managing hypercoagulation. Antithrombin resistance is a disease in which a missense variant of the prothrombin gene, prothrombin Yukuhashi, occurs in a hypercoagulation state. We present 2 parent-child cases of antithrombin resistance-induced chronic thromboembolic pulmonary disease with pulmonary hypertension. Thromboembolic events differed between the 2 patients, suggesting differences in coagulation abilities. Rotational thromboelastometry was useful for evaluating individual coagulation–fibrinolysis dynamics. Personalized management of anticoagulation therapy based on a precise evaluation of coagulation ability is needed in hypercoagulation states. |
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| ISSN: | 2767-7664 |