Cerebral perfusion differences in the visual cortex and fusiform subregions across the psychosis spectrum
BackgroundApproximately 50% of individuals with psychosis spectrum disorders (PSD) experience visual hallucinations and deficits in visual processing. Cerebral blood flow (CBF) alterations have been identified in the occipital lobe (OL) and fusiform gyrus (FG) in PSD. However, prior studies neither...
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Frontiers Media S.A.
2025-04-01
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| author | Jothini Sritharan Jothini Sritharan Jothini Sritharan Jothini Sritharan Victor Zeng Victor Zeng Jan Petr Henk-Jan Mutsaerts Henk-Jan Mutsaerts Dung Hoang Dung Hoang Nicolas R. Bolo Nicolas R. Bolo Elena I. Ivleva Weiying Dai Elliot S. Gershon Sarah K. Keedy David A. Parker Rebekah L. Trotti Rebekah L. Trotti Jennifer E. McDowell Brett A. Clementz Carol A. Tamminga Godfrey D. Pearlson Godfrey D. Pearlson Matcheri S. Keshavan Matcheri S. Keshavan Paulo Lizano Paulo Lizano Paulo Lizano |
| author_facet | Jothini Sritharan Jothini Sritharan Jothini Sritharan Jothini Sritharan Victor Zeng Victor Zeng Jan Petr Henk-Jan Mutsaerts Henk-Jan Mutsaerts Dung Hoang Dung Hoang Nicolas R. Bolo Nicolas R. Bolo Elena I. Ivleva Weiying Dai Elliot S. Gershon Sarah K. Keedy David A. Parker Rebekah L. Trotti Rebekah L. Trotti Jennifer E. McDowell Brett A. Clementz Carol A. Tamminga Godfrey D. Pearlson Godfrey D. Pearlson Matcheri S. Keshavan Matcheri S. Keshavan Paulo Lizano Paulo Lizano Paulo Lizano |
| author_sort | Jothini Sritharan |
| collection | DOAJ |
| description | BackgroundApproximately 50% of individuals with psychosis spectrum disorders (PSD) experience visual hallucinations and deficits in visual processing. Cerebral blood flow (CBF) alterations have been identified in the occipital lobe (OL) and fusiform gyrus (FG) in PSD. However, prior studies neither report on cytoarchitectonic subregions of the OL or FG, nor their correlations with cognition. Moreover, perfusion differences across neurobiologically defined psychosis Biotypes in these regions are not investigated yet.MethodsExploreASL and FreeSurfer were used to extract perfusion measures from pseudo-continuous arterial spin labeling scans of visual (hOc1-hOc3v, middle temporal area (MT)) and fusiform (FG2-FG4) subregions in 122 bipolar disorder with psychosis (BP), 179 schizoaffective disorder (SAD), 203 schizophrenia (SZ), and 350 healthy controls (NC), as well as psychosis Biotypes (BT1-3). The data was adjusted for scanner effects using ComBat. Analyses were co-varied for total gray matter CBF. We used R to perform statistical comparisons across PSD and NC and across Biotypes. Partial Spearman correlation was performed between CBF and cognitive measures. Benjamini & Hochberg correction was used to correct for multiple comparisons.ResultsPSD exhibited greater perfusion in MT and FG2 compared to NC. Perfusion significantly differed across psychosis Biotypes in hOc1 but not across diagnostic groups. Higher MT and FG4 perfusion in PSD were associated with worse overall cognitive performance.ConclusionsVisual and fusiform subregions demonstrate significant perfusion alterations which may indicate neurovascular deficits in PSD. Moreover, these perfusion alterations may contribute to cognitive impairments and visual abnormalities in psychosis. |
| format | Article |
| id | doaj-art-767447ce80cd4f85ba6d1c6b2c45bb5c |
| institution | OA Journals |
| issn | 1664-0640 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Psychiatry |
| spelling | doaj-art-767447ce80cd4f85ba6d1c6b2c45bb5c2025-08-20T02:19:19ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402025-04-011610.3389/fpsyt.2025.15661841566184Cerebral perfusion differences in the visual cortex and fusiform subregions across the psychosis spectrumJothini Sritharan0Jothini Sritharan1Jothini Sritharan2Jothini Sritharan3Victor Zeng4Victor Zeng5Jan Petr6Henk-Jan Mutsaerts7Henk-Jan Mutsaerts8Dung Hoang9Dung Hoang10Nicolas R. Bolo11Nicolas R. Bolo12Elena I. Ivleva13Weiying Dai14Elliot S. Gershon15Sarah K. Keedy16David A. Parker17Rebekah L. Trotti18Rebekah L. Trotti19Jennifer E. McDowell20Brett A. Clementz21Carol A. Tamminga22Godfrey D. Pearlson23Godfrey D. Pearlson24Matcheri S. Keshavan25Matcheri S. Keshavan26Paulo Lizano27Paulo Lizano28Paulo Lizano29Advanced Imaging Research Group, Swiss Paraplegic Research, Nottwil, SwitzerlandDepartment of Information Technology and Electrical Engineering, Eidgenössische Technische Hochschule (ETH) Zurich, Zurich, SwitzerlandDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, United StatesDivision of Translational Neuroscience, Beth Israel Deaconess Medical Center, Boston, MA, United StatesDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, United StatesDivision of Translational Neuroscience, Beth Israel Deaconess Medical Center, Boston, MA, United StatesInstitute for Radiopharmaceutical Cancer Research, Helmholtz Center Dresden-Rossendorf, Dresden, Saxony, GermanyDepartment of Radiology and Nuclear Medicine, Location VU University Medical Center, Amsterdam University Medical Center, Amsterdam, NetherlandsAmsterdam Neuroscience, Brain Imaging, Amsterdam, NetherlandsDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, United StatesDivision of Translational Neuroscience, Beth Israel Deaconess Medical Center, Boston, MA, United StatesDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, United StatesDepartment of Psychiatry, Harvard Medical School, Boston, MA, United StatesDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, United States0School of Computing, Binghamton University, Binghamton, NY, United States1Department of Psychiatry, University of Chicago, Chicago, IL, United States1Department of Psychiatry, University of Chicago, Chicago, IL, United States2Departments of Psychology and Neuroscience, BioImaging Research Center, University of Georgia, Athens, GA, United StatesDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, United StatesDivision of Translational Neuroscience, Beth Israel Deaconess Medical Center, Boston, MA, United States2Departments of Psychology and Neuroscience, BioImaging Research Center, University of Georgia, Athens, GA, United States2Departments of Psychology and Neuroscience, BioImaging Research Center, University of Georgia, Athens, GA, United StatesDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, United States3Olin Neuropsychiatry Research Center/Institute of Living, Hartford Hospital, Hartford, CT, United States4Departments of Psychiatry and Neuroscience, Yale University, New Haven, CT, United StatesDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, United StatesDepartment of Psychiatry, Harvard Medical School, Boston, MA, United StatesDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, United StatesDivision of Translational Neuroscience, Beth Israel Deaconess Medical Center, Boston, MA, United StatesDepartment of Psychiatry, Harvard Medical School, Boston, MA, United StatesBackgroundApproximately 50% of individuals with psychosis spectrum disorders (PSD) experience visual hallucinations and deficits in visual processing. Cerebral blood flow (CBF) alterations have been identified in the occipital lobe (OL) and fusiform gyrus (FG) in PSD. However, prior studies neither report on cytoarchitectonic subregions of the OL or FG, nor their correlations with cognition. Moreover, perfusion differences across neurobiologically defined psychosis Biotypes in these regions are not investigated yet.MethodsExploreASL and FreeSurfer were used to extract perfusion measures from pseudo-continuous arterial spin labeling scans of visual (hOc1-hOc3v, middle temporal area (MT)) and fusiform (FG2-FG4) subregions in 122 bipolar disorder with psychosis (BP), 179 schizoaffective disorder (SAD), 203 schizophrenia (SZ), and 350 healthy controls (NC), as well as psychosis Biotypes (BT1-3). The data was adjusted for scanner effects using ComBat. Analyses were co-varied for total gray matter CBF. We used R to perform statistical comparisons across PSD and NC and across Biotypes. Partial Spearman correlation was performed between CBF and cognitive measures. Benjamini & Hochberg correction was used to correct for multiple comparisons.ResultsPSD exhibited greater perfusion in MT and FG2 compared to NC. Perfusion significantly differed across psychosis Biotypes in hOc1 but not across diagnostic groups. Higher MT and FG4 perfusion in PSD were associated with worse overall cognitive performance.ConclusionsVisual and fusiform subregions demonstrate significant perfusion alterations which may indicate neurovascular deficits in PSD. Moreover, these perfusion alterations may contribute to cognitive impairments and visual abnormalities in psychosis.https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1566184/fullarterial spin labelingcerebral blood flowV5/MTfusiform gyruspsychosis spectrum disorderscognition |
| spellingShingle | Jothini Sritharan Jothini Sritharan Jothini Sritharan Jothini Sritharan Victor Zeng Victor Zeng Jan Petr Henk-Jan Mutsaerts Henk-Jan Mutsaerts Dung Hoang Dung Hoang Nicolas R. Bolo Nicolas R. Bolo Elena I. Ivleva Weiying Dai Elliot S. Gershon Sarah K. Keedy David A. Parker Rebekah L. Trotti Rebekah L. Trotti Jennifer E. McDowell Brett A. Clementz Carol A. Tamminga Godfrey D. Pearlson Godfrey D. Pearlson Matcheri S. Keshavan Matcheri S. Keshavan Paulo Lizano Paulo Lizano Paulo Lizano Cerebral perfusion differences in the visual cortex and fusiform subregions across the psychosis spectrum Frontiers in Psychiatry arterial spin labeling cerebral blood flow V5/MT fusiform gyrus psychosis spectrum disorders cognition |
| title | Cerebral perfusion differences in the visual cortex and fusiform subregions across the psychosis spectrum |
| title_full | Cerebral perfusion differences in the visual cortex and fusiform subregions across the psychosis spectrum |
| title_fullStr | Cerebral perfusion differences in the visual cortex and fusiform subregions across the psychosis spectrum |
| title_full_unstemmed | Cerebral perfusion differences in the visual cortex and fusiform subregions across the psychosis spectrum |
| title_short | Cerebral perfusion differences in the visual cortex and fusiform subregions across the psychosis spectrum |
| title_sort | cerebral perfusion differences in the visual cortex and fusiform subregions across the psychosis spectrum |
| topic | arterial spin labeling cerebral blood flow V5/MT fusiform gyrus psychosis spectrum disorders cognition |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1566184/full |
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