Expanding diversity in developmental profiles of very-low-birth-weight infants during 6 years after birth
Abstract Very-low-birth-weight infants (VLBWIs) are at high risk for neurodevelopmental problems after age 3 years. We investigated the association between the developmental quotient (DQ) of VLBWIs and their growth profiles during 6 years after birth. Participants were VLBWIs born at Kokura Medical...
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Nature Portfolio
2025-02-01
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| Online Access: | https://doi.org/10.1038/s41598-025-88721-x |
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| author | Kyoko Watanabe Reina Ogata Kenta Kajiwara Hirosuke Inoue Yoshihiro Sakemi Masako Ichiyama Toru Sawano Kazuaki Yasuoka Takahide Watabe Hiroaki Kurata Toshinori Nakashima Yuri Sonoda Pin Fee Chong Satoshi Akamine Masayuki Ochiai Takuro Ohno Hironori Yamashita Yasunari Sakai Shouichi Ohga |
| author_facet | Kyoko Watanabe Reina Ogata Kenta Kajiwara Hirosuke Inoue Yoshihiro Sakemi Masako Ichiyama Toru Sawano Kazuaki Yasuoka Takahide Watabe Hiroaki Kurata Toshinori Nakashima Yuri Sonoda Pin Fee Chong Satoshi Akamine Masayuki Ochiai Takuro Ohno Hironori Yamashita Yasunari Sakai Shouichi Ohga |
| author_sort | Kyoko Watanabe |
| collection | DOAJ |
| description | Abstract Very-low-birth-weight infants (VLBWIs) are at high risk for neurodevelopmental problems after age 3 years. We investigated the association between the developmental quotient (DQ) of VLBWIs and their growth profiles during 6 years after birth. Participants were VLBWIs born at Kokura Medical Center (the first cohort) and Kyushu University Hospital (the second cohort) between 2012 and 2017. Recorded charts were used to collect growth profiles and developmental quotients (DQ) of the participants until age 6 years. In the first cohort (n = 64), the DQ values at age 6 years were correlated with those at age 3 years. VLBWIs with DQ ≥ 85 at age 6 years had a higher body weight and height at age 3 years than those with DQ < 85. The second cohort (n = 69) validated these findings. A comparative analysis of the two cohorts revealed that the DQ of VLBWIs was dissociated from their growth profiles after age 3 years. Clustering analyses indicated that DQ values at age 3 years predicted better the prognosis of VLBWIs with DQ ≥ 85 at age 6 years than their growth profiles. This study demonstrates that VLBWIs gain divergent profiles in growth, development, and growth-and-development correlation during postnatal 6 years. |
| format | Article |
| id | doaj-art-76705c8471e64d74a31e1499b7066f49 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-76705c8471e64d74a31e1499b7066f492025-02-09T12:35:58ZengNature PortfolioScientific Reports2045-23222025-02-0115111210.1038/s41598-025-88721-xExpanding diversity in developmental profiles of very-low-birth-weight infants during 6 years after birthKyoko Watanabe0Reina Ogata1Kenta Kajiwara2Hirosuke Inoue3Yoshihiro Sakemi4Masako Ichiyama5Toru Sawano6Kazuaki Yasuoka7Takahide Watabe8Hiroaki Kurata9Toshinori Nakashima10Yuri Sonoda11Pin Fee Chong12Satoshi Akamine13Masayuki Ochiai14Takuro Ohno15Hironori Yamashita16Yasunari Sakai17Shouichi Ohga18Department of Pediatrics, NHO Kokura Medical CenterDepartment of Pediatrics, NHO Kokura Medical CenterDepartment of Pediatrics, Graduate School of Medical Sciences, Kyushu UniversityDepartment of Pediatrics, Graduate School of Medical Sciences, Kyushu UniversityDepartment of Pediatrics, NHO Kokura Medical CenterDepartment of Pediatrics, NHO Kokura Medical CenterDepartment of Pediatrics, NHO Kokura Medical CenterDepartment of Pediatrics, Graduate School of Medical Sciences, Kyushu UniversityDepartment of Pediatrics, Graduate School of Medical Sciences, Kyushu UniversityDepartment of Pediatrics, NHO Kokura Medical CenterDepartment of Pediatrics, NHO Kokura Medical CenterDepartment of Pediatrics, Graduate School of Medical Sciences, Kyushu UniversityDepartment of Pediatrics, Graduate School of Medical Sciences, Kyushu UniversityDepartment of Pediatrics, Graduate School of Medical Sciences, Kyushu UniversityDepartment of Pediatrics, Graduate School of Medical Sciences, Kyushu UniversityDepartment of Pediatrics, NHO Kokura Medical CenterDepartment of Pediatrics, NHO Kokura Medical CenterDepartment of Pediatrics, Graduate School of Medical Sciences, Kyushu UniversityDepartment of Pediatrics, Graduate School of Medical Sciences, Kyushu UniversityAbstract Very-low-birth-weight infants (VLBWIs) are at high risk for neurodevelopmental problems after age 3 years. We investigated the association between the developmental quotient (DQ) of VLBWIs and their growth profiles during 6 years after birth. Participants were VLBWIs born at Kokura Medical Center (the first cohort) and Kyushu University Hospital (the second cohort) between 2012 and 2017. Recorded charts were used to collect growth profiles and developmental quotients (DQ) of the participants until age 6 years. In the first cohort (n = 64), the DQ values at age 6 years were correlated with those at age 3 years. VLBWIs with DQ ≥ 85 at age 6 years had a higher body weight and height at age 3 years than those with DQ < 85. The second cohort (n = 69) validated these findings. A comparative analysis of the two cohorts revealed that the DQ of VLBWIs was dissociated from their growth profiles after age 3 years. Clustering analyses indicated that DQ values at age 3 years predicted better the prognosis of VLBWIs with DQ ≥ 85 at age 6 years than their growth profiles. This study demonstrates that VLBWIs gain divergent profiles in growth, development, and growth-and-development correlation during postnatal 6 years.https://doi.org/10.1038/s41598-025-88721-xVery-low-birth-weight infants (VLBWIs)GrowthDevelopmentCorrelationDivergenceAge |
| spellingShingle | Kyoko Watanabe Reina Ogata Kenta Kajiwara Hirosuke Inoue Yoshihiro Sakemi Masako Ichiyama Toru Sawano Kazuaki Yasuoka Takahide Watabe Hiroaki Kurata Toshinori Nakashima Yuri Sonoda Pin Fee Chong Satoshi Akamine Masayuki Ochiai Takuro Ohno Hironori Yamashita Yasunari Sakai Shouichi Ohga Expanding diversity in developmental profiles of very-low-birth-weight infants during 6 years after birth Scientific Reports Very-low-birth-weight infants (VLBWIs) Growth Development Correlation Divergence Age |
| title | Expanding diversity in developmental profiles of very-low-birth-weight infants during 6 years after birth |
| title_full | Expanding diversity in developmental profiles of very-low-birth-weight infants during 6 years after birth |
| title_fullStr | Expanding diversity in developmental profiles of very-low-birth-weight infants during 6 years after birth |
| title_full_unstemmed | Expanding diversity in developmental profiles of very-low-birth-weight infants during 6 years after birth |
| title_short | Expanding diversity in developmental profiles of very-low-birth-weight infants during 6 years after birth |
| title_sort | expanding diversity in developmental profiles of very low birth weight infants during 6 years after birth |
| topic | Very-low-birth-weight infants (VLBWIs) Growth Development Correlation Divergence Age |
| url | https://doi.org/10.1038/s41598-025-88721-x |
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