Cortical propagation tracks functional recovery after stroke.
Stroke is a debilitating condition affecting millions of people worldwide. The development of improved rehabilitation therapies rests on finding biomarkers suitable for tracking functional damage and recovery. To achieve this goal, we perform a spatiotemporal analysis of cortical activity obtained b...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-05-01
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| Series: | PLoS Computational Biology |
| Online Access: | https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008963&type=printable |
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| author | Gloria Cecchini Alessandro Scaglione Anna Letizia Allegra Mascaro Curzio Checcucci Emilia Conti Ihusan Adam Duccio Fanelli Roberto Livi Francesco Saverio Pavone Thomas Kreuz |
| author_facet | Gloria Cecchini Alessandro Scaglione Anna Letizia Allegra Mascaro Curzio Checcucci Emilia Conti Ihusan Adam Duccio Fanelli Roberto Livi Francesco Saverio Pavone Thomas Kreuz |
| author_sort | Gloria Cecchini |
| collection | DOAJ |
| description | Stroke is a debilitating condition affecting millions of people worldwide. The development of improved rehabilitation therapies rests on finding biomarkers suitable for tracking functional damage and recovery. To achieve this goal, we perform a spatiotemporal analysis of cortical activity obtained by wide-field calcium images in mice before and after stroke. We compare spontaneous recovery with three different post-stroke rehabilitation paradigms, motor training alone, pharmacological contralesional inactivation and both combined. We identify three novel indicators that are able to track how movement-evoked global activation patterns are impaired by stroke and evolve during rehabilitation: the duration, the smoothness, and the angle of individual propagation events. Results show that, compared to pre-stroke conditions, propagation of cortical activity in the subacute phase right after stroke is slowed down and more irregular. When comparing rehabilitation paradigms, we find that mice treated with both motor training and pharmacological intervention, the only group associated with generalized recovery, manifest new propagation patterns, that are even faster and smoother than before the stroke. In conclusion, our new spatiotemporal propagation indicators could represent promising biomarkers that are able to uncover neural correlates not only of motor deficits caused by stroke but also of functional recovery during rehabilitation. In turn, these insights could pave the way towards more targeted post-stroke therapies. |
| format | Article |
| id | doaj-art-766cd56b70f84e5aa949c0380a0c8dcc |
| institution | OA Journals |
| issn | 1553-734X 1553-7358 |
| language | English |
| publishDate | 2021-05-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj-art-766cd56b70f84e5aa949c0380a0c8dcc2025-08-20T02:01:04ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582021-05-01175e100896310.1371/journal.pcbi.1008963Cortical propagation tracks functional recovery after stroke.Gloria CecchiniAlessandro ScaglioneAnna Letizia Allegra MascaroCurzio CheccucciEmilia ContiIhusan AdamDuccio FanelliRoberto LiviFrancesco Saverio PavoneThomas KreuzStroke is a debilitating condition affecting millions of people worldwide. The development of improved rehabilitation therapies rests on finding biomarkers suitable for tracking functional damage and recovery. To achieve this goal, we perform a spatiotemporal analysis of cortical activity obtained by wide-field calcium images in mice before and after stroke. We compare spontaneous recovery with three different post-stroke rehabilitation paradigms, motor training alone, pharmacological contralesional inactivation and both combined. We identify three novel indicators that are able to track how movement-evoked global activation patterns are impaired by stroke and evolve during rehabilitation: the duration, the smoothness, and the angle of individual propagation events. Results show that, compared to pre-stroke conditions, propagation of cortical activity in the subacute phase right after stroke is slowed down and more irregular. When comparing rehabilitation paradigms, we find that mice treated with both motor training and pharmacological intervention, the only group associated with generalized recovery, manifest new propagation patterns, that are even faster and smoother than before the stroke. In conclusion, our new spatiotemporal propagation indicators could represent promising biomarkers that are able to uncover neural correlates not only of motor deficits caused by stroke but also of functional recovery during rehabilitation. In turn, these insights could pave the way towards more targeted post-stroke therapies.https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008963&type=printable |
| spellingShingle | Gloria Cecchini Alessandro Scaglione Anna Letizia Allegra Mascaro Curzio Checcucci Emilia Conti Ihusan Adam Duccio Fanelli Roberto Livi Francesco Saverio Pavone Thomas Kreuz Cortical propagation tracks functional recovery after stroke. PLoS Computational Biology |
| title | Cortical propagation tracks functional recovery after stroke. |
| title_full | Cortical propagation tracks functional recovery after stroke. |
| title_fullStr | Cortical propagation tracks functional recovery after stroke. |
| title_full_unstemmed | Cortical propagation tracks functional recovery after stroke. |
| title_short | Cortical propagation tracks functional recovery after stroke. |
| title_sort | cortical propagation tracks functional recovery after stroke |
| url | https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008963&type=printable |
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