Risk of infective endocarditis in patients with mitral valve prolapse: Systematic review with meta-analysis
Aims: Infective endocarditis (IE) is a serious heart valvular condition. While mitral valve prolapse (MVP) has been associated with an increased risk of IE, the magnitude of this association remains poorly quantified. This systematic review aimed to better estimate the risk of developing IE among MV...
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Elsevier
2024-11-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024159245 |
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| author | Luisa Marques Catarina de Sousa Fausto J. Pinto Daniel Caldeira |
| author_facet | Luisa Marques Catarina de Sousa Fausto J. Pinto Daniel Caldeira |
| author_sort | Luisa Marques |
| collection | DOAJ |
| description | Aims: Infective endocarditis (IE) is a serious heart valvular condition. While mitral valve prolapse (MVP) has been associated with an increased risk of IE, the magnitude of this association remains poorly quantified. This systematic review aimed to better estimate the risk of developing IE among MVP patients compared with the general population. Methods: MEDLINE, Cochrane Library (CENTRAL) and Web of Science databases were searched electronically to find all the relevant cohort and case-control studies. Pooled estimates of odds ratios (ORs) and 95 % confidence intervals (CIs) were derived by random effects meta-analysis. Heterogeneity was assessed using the I2 test. Results: A total of six studies were considered eligible, and the obtained results showed that MVP patients had a higher risk of IE when compared to the general population (OR 7.83, 95 % CI 5.11, 12.02; I2 = 0 %). Posterior analysis according to the risk of bias and study design didn't show any significant variations in the direction and magnitude of the effect. Conclusion: The magnitude of increased risk of IE of 7-fold warrants further attention for patients with MVP. Further contemporary studies and prophylaxis studies should be considered. |
| format | Article |
| id | doaj-art-766c650206aa48a4b7ded83146800770 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-766c650206aa48a4b7ded831468007702024-11-15T06:13:54ZengElsevierHeliyon2405-84402024-11-011021e39893Risk of infective endocarditis in patients with mitral valve prolapse: Systematic review with meta-analysisLuisa Marques0Catarina de Sousa1Fausto J. Pinto2Daniel Caldeira3Faculdade de Medicina, Universidade de Lisboa, PortugalCardiology Department, Hospital Universitário de Santa Maria – ULS Santa Maria (ULSSM), CAML, Portugal; Centro Cardiovascular da Universidade de Lisboa – CCUL (CCUL@RISE), CAML, Faculdade de Medicina, Universidade de Lisboa, PortugalCardiology Department, Hospital Universitário de Santa Maria – ULS Santa Maria (ULSSM), CAML, Portugal; Centro Cardiovascular da Universidade de Lisboa – CCUL (CCUL@RISE), CAML, Faculdade de Medicina, Universidade de Lisboa, PortugalCardiology Department, Hospital Universitário de Santa Maria – ULS Santa Maria (ULSSM), CAML, Portugal; Centro Cardiovascular da Universidade de Lisboa – CCUL (CCUL@RISE), CAML, Faculdade de Medicina, Universidade de Lisboa, Portugal; Centro de Estudos de Medicina Baseada na Evidência (CEMBE), Faculdade de Medicina, Universidade de Lisboa, Portugal; Laboratory of Clinical Pharmacology and Therapeutics, Faculdade de Medicina, Universidade de Lisboa, Portugal; Corresponding author. Centro Cardiovascular da Universidade de Lisboa (CCUL), Faculdade de Medicina da Universidade de Lisboa, Av. Prof. Egas Moniz, Lisboa, 1649-028, Portugal.Aims: Infective endocarditis (IE) is a serious heart valvular condition. While mitral valve prolapse (MVP) has been associated with an increased risk of IE, the magnitude of this association remains poorly quantified. This systematic review aimed to better estimate the risk of developing IE among MVP patients compared with the general population. Methods: MEDLINE, Cochrane Library (CENTRAL) and Web of Science databases were searched electronically to find all the relevant cohort and case-control studies. Pooled estimates of odds ratios (ORs) and 95 % confidence intervals (CIs) were derived by random effects meta-analysis. Heterogeneity was assessed using the I2 test. Results: A total of six studies were considered eligible, and the obtained results showed that MVP patients had a higher risk of IE when compared to the general population (OR 7.83, 95 % CI 5.11, 12.02; I2 = 0 %). Posterior analysis according to the risk of bias and study design didn't show any significant variations in the direction and magnitude of the effect. Conclusion: The magnitude of increased risk of IE of 7-fold warrants further attention for patients with MVP. Further contemporary studies and prophylaxis studies should be considered.http://www.sciencedirect.com/science/article/pii/S2405844024159245Infective endocarditisMitral valve prolapseBillowingAntibioticBarlow disease |
| spellingShingle | Luisa Marques Catarina de Sousa Fausto J. Pinto Daniel Caldeira Risk of infective endocarditis in patients with mitral valve prolapse: Systematic review with meta-analysis Heliyon Infective endocarditis Mitral valve prolapse Billowing Antibiotic Barlow disease |
| title | Risk of infective endocarditis in patients with mitral valve prolapse: Systematic review with meta-analysis |
| title_full | Risk of infective endocarditis in patients with mitral valve prolapse: Systematic review with meta-analysis |
| title_fullStr | Risk of infective endocarditis in patients with mitral valve prolapse: Systematic review with meta-analysis |
| title_full_unstemmed | Risk of infective endocarditis in patients with mitral valve prolapse: Systematic review with meta-analysis |
| title_short | Risk of infective endocarditis in patients with mitral valve prolapse: Systematic review with meta-analysis |
| title_sort | risk of infective endocarditis in patients with mitral valve prolapse systematic review with meta analysis |
| topic | Infective endocarditis Mitral valve prolapse Billowing Antibiotic Barlow disease |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024159245 |
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