Nanobiosensors in neurodegenerative disease diagnosis: A promising pathway for early detection
Neurodegenerative diseases, including Alzheimer's and Parkinson's, are characterized by progressive neuronal loss, leading to cognitive and motor impairments. Early diagnosis remains a challenge due to the slow progression of symptoms and the limitations of current diagnostic methods. Nano...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-05-01
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| Series: | Digital Health |
| Online Access: | https://doi.org/10.1177/20552076251342457 |
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| author | Shikha Yadav Sarad Pawar Naik Bukke Shatrudhan Prajapati Ajay Pal Singh Ananda Kumar Chettupalli Buyinza Nicholas |
| author_facet | Shikha Yadav Sarad Pawar Naik Bukke Shatrudhan Prajapati Ajay Pal Singh Ananda Kumar Chettupalli Buyinza Nicholas |
| author_sort | Shikha Yadav |
| collection | DOAJ |
| description | Neurodegenerative diseases, including Alzheimer's and Parkinson's, are characterized by progressive neuronal loss, leading to cognitive and motor impairments. Early diagnosis remains a challenge due to the slow progression of symptoms and the limitations of current diagnostic methods. Nanobiosensors, leveraging the high sensitivity and specificity of nanotechnology, offer a promising, noninvasive, and cost-effective approach for detecting disease biomarkers at ultra-low concentrations. This review highlights recent advancements in nanobiosensor technology, including the integration of gold nanoparticles, quantum dots, and carbon nanotubes, which have significantly enhanced biomarker detection precision. Furthermore, it examines the advantages of nanobiosensors over traditional diagnostic techniques, such as improved sensitivity, rapid detection, and minimal invasiveness. The potential of these innovative sensors to revolutionize early disease detection and improve patient outcomes is discussed, along with existing challenges in clinical translation, including stability, reproducibility, and regulatory considerations. Addressing these limitations will be crucial for integrating nanobiosensors into routine clinical practice and advancing personalized medicine for neurodegenerative disorders. |
| format | Article |
| id | doaj-art-766c1d7a4fcb44d2bd864fd709f939bf |
| institution | Kabale University |
| issn | 2055-2076 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Digital Health |
| spelling | doaj-art-766c1d7a4fcb44d2bd864fd709f939bf2025-08-20T03:49:45ZengSAGE PublishingDigital Health2055-20762025-05-011110.1177/20552076251342457Nanobiosensors in neurodegenerative disease diagnosis: A promising pathway for early detectionShikha Yadav0Sarad Pawar Naik Bukke1Shatrudhan Prajapati2Ajay Pal Singh3Ananda Kumar Chettupalli4Buyinza Nicholas5 Department of Pharmaceutical Sciences, , Greater Noida, Uttar Pradesh, India Department of Pharmaceutics and Pharmaceutical Technology, , Ishaka-Bushenyi, Uganda School of Pharmacy, , Faridabad, Haryana, India School of Pharmacy, , Faridabad, Haryana, India Department of Pharmaceutical Sciences, , Greater Noida, Uttar Pradesh, India Department of Pharmaceutics and Pharmaceutical Technology, , Ishaka-Bushenyi, UgandaNeurodegenerative diseases, including Alzheimer's and Parkinson's, are characterized by progressive neuronal loss, leading to cognitive and motor impairments. Early diagnosis remains a challenge due to the slow progression of symptoms and the limitations of current diagnostic methods. Nanobiosensors, leveraging the high sensitivity and specificity of nanotechnology, offer a promising, noninvasive, and cost-effective approach for detecting disease biomarkers at ultra-low concentrations. This review highlights recent advancements in nanobiosensor technology, including the integration of gold nanoparticles, quantum dots, and carbon nanotubes, which have significantly enhanced biomarker detection precision. Furthermore, it examines the advantages of nanobiosensors over traditional diagnostic techniques, such as improved sensitivity, rapid detection, and minimal invasiveness. The potential of these innovative sensors to revolutionize early disease detection and improve patient outcomes is discussed, along with existing challenges in clinical translation, including stability, reproducibility, and regulatory considerations. Addressing these limitations will be crucial for integrating nanobiosensors into routine clinical practice and advancing personalized medicine for neurodegenerative disorders.https://doi.org/10.1177/20552076251342457 |
| spellingShingle | Shikha Yadav Sarad Pawar Naik Bukke Shatrudhan Prajapati Ajay Pal Singh Ananda Kumar Chettupalli Buyinza Nicholas Nanobiosensors in neurodegenerative disease diagnosis: A promising pathway for early detection Digital Health |
| title | Nanobiosensors in neurodegenerative disease diagnosis: A promising pathway for early detection |
| title_full | Nanobiosensors in neurodegenerative disease diagnosis: A promising pathway for early detection |
| title_fullStr | Nanobiosensors in neurodegenerative disease diagnosis: A promising pathway for early detection |
| title_full_unstemmed | Nanobiosensors in neurodegenerative disease diagnosis: A promising pathway for early detection |
| title_short | Nanobiosensors in neurodegenerative disease diagnosis: A promising pathway for early detection |
| title_sort | nanobiosensors in neurodegenerative disease diagnosis a promising pathway for early detection |
| url | https://doi.org/10.1177/20552076251342457 |
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