Glaesserella parasuis infection triggers endoplasmic reticulum stress-mediated pyroptosis via PERK/eIF2α/ATF4 axis and metabolic reprogramming in porcine alveolar macrophages

Glaesserella parasuis infection triggers endoplasmic reticulum stress-mediated pyroptosis via PERK/eIF2α/ATF4 axis and metabolic reprogramming in porcine alveolar macrophages

Abstract Glaesserella parasuis, the causative agent of Glässer’s disease in swine, triggers severe systemic inflammation; however, the molecular mechanisms underpinning its pathogenesis remain incompletely understood. This study investigated the cellular and metabolic responses of porcine alveolar m...

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Bibliographic Details
Main Authors: Weili Feng, Yu Han, Wanyun Zhang, Lei Wu, Ao Zhou, Liangyu Shi, Jing Zhang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Veterinary Research
Subjects:
Glaesserella parasuis
porcine alveolar macrophages
apoptosis
pyroptosis
endoplasmic reticulum stress
metabolic reprogramming
Online Access:https://doi.org/10.1186/s13567-025-01580-2
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