Role of the Cysteinyl Leukotrienes in the Pathogenesis and Progression of Cardiovascular Diseases
Cysteinyl leukotrienes (CysLTs) are potent lipid inflammatory mediators synthesized from arachidonic acid, through the 5-lipoxygenase (5-LO) pathway. Owing to their properties, CysLTs play a crucial role in the pathogenesis of inflammation; therefore, CysLT modifiers as synthesis inhibitors or recep...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/2432958 |
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| author | Francesca Colazzo Paolo Gelosa Elena Tremoli Luigi Sironi Laura Castiglioni |
| author_facet | Francesca Colazzo Paolo Gelosa Elena Tremoli Luigi Sironi Laura Castiglioni |
| author_sort | Francesca Colazzo |
| collection | DOAJ |
| description | Cysteinyl leukotrienes (CysLTs) are potent lipid inflammatory mediators synthesized from arachidonic acid, through the 5-lipoxygenase (5-LO) pathway. Owing to their properties, CysLTs play a crucial role in the pathogenesis of inflammation; therefore, CysLT modifiers as synthesis inhibitors or receptor antagonists, central in asthma management, may become a potential target for the treatment of other inflammatory diseases such as the cardiovascular disorders. 5-LO pathway activation and increased expression of its mediators and receptors are found in cardiovascular diseases. Moreover, the cardioprotective effects observed by using CysLT modifiers are promising and contribute to elucidate the link between CysLTs and cardiovascular disease. The aim of this review is to summarize the state of present research about the role of the CysLTs in the pathogenesis and progression of atherosclerosis and myocardial infarction. |
| format | Article |
| id | doaj-art-766aa4bd801f41d59bb1ec8f5c6879c1 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-766aa4bd801f41d59bb1ec8f5c6879c12025-08-20T02:07:13ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/24329582432958Role of the Cysteinyl Leukotrienes in the Pathogenesis and Progression of Cardiovascular DiseasesFrancesca Colazzo0Paolo Gelosa1Elena Tremoli2Luigi Sironi3Laura Castiglioni4Centro Cardiologico Monzino IRCCS, Via Carlo Parea 4, 20138 Milan, ItalyCentro Cardiologico Monzino IRCCS, Via Carlo Parea 4, 20138 Milan, ItalyCentro Cardiologico Monzino IRCCS, Via Carlo Parea 4, 20138 Milan, ItalyCentro Cardiologico Monzino IRCCS, Via Carlo Parea 4, 20138 Milan, ItalyDepartment of Pharmacological and Biomolecular Sciences, University of Milan, Via Giuseppe Balzaretti 9, 20133 Milan, ItalyCysteinyl leukotrienes (CysLTs) are potent lipid inflammatory mediators synthesized from arachidonic acid, through the 5-lipoxygenase (5-LO) pathway. Owing to their properties, CysLTs play a crucial role in the pathogenesis of inflammation; therefore, CysLT modifiers as synthesis inhibitors or receptor antagonists, central in asthma management, may become a potential target for the treatment of other inflammatory diseases such as the cardiovascular disorders. 5-LO pathway activation and increased expression of its mediators and receptors are found in cardiovascular diseases. Moreover, the cardioprotective effects observed by using CysLT modifiers are promising and contribute to elucidate the link between CysLTs and cardiovascular disease. The aim of this review is to summarize the state of present research about the role of the CysLTs in the pathogenesis and progression of atherosclerosis and myocardial infarction.http://dx.doi.org/10.1155/2017/2432958 |
| spellingShingle | Francesca Colazzo Paolo Gelosa Elena Tremoli Luigi Sironi Laura Castiglioni Role of the Cysteinyl Leukotrienes in the Pathogenesis and Progression of Cardiovascular Diseases Mediators of Inflammation |
| title | Role of the Cysteinyl Leukotrienes in the Pathogenesis and Progression of Cardiovascular Diseases |
| title_full | Role of the Cysteinyl Leukotrienes in the Pathogenesis and Progression of Cardiovascular Diseases |
| title_fullStr | Role of the Cysteinyl Leukotrienes in the Pathogenesis and Progression of Cardiovascular Diseases |
| title_full_unstemmed | Role of the Cysteinyl Leukotrienes in the Pathogenesis and Progression of Cardiovascular Diseases |
| title_short | Role of the Cysteinyl Leukotrienes in the Pathogenesis and Progression of Cardiovascular Diseases |
| title_sort | role of the cysteinyl leukotrienes in the pathogenesis and progression of cardiovascular diseases |
| url | http://dx.doi.org/10.1155/2017/2432958 |
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